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Vocal fold augmentation with injectable calcium hydroxylapatite: short-term results.
J Voice. 2004 Sep; 18(3):387-91.JV

Abstract

Symptoms of unilateral vocal fold paralysis are improved significantly by augmenting the paralyzed vocal fold via vocal fold injection. In this trial, augmentation with a new calcium hydroxylapatite implant was evaluated. In addition, two different phonosurgical injection techniques were used, and these procedures were compared for accuracy and reliability. A total of 11 terminal patients with unilateral vocal fold paralysis underwent vocal fold injection with calcium hydroxylapatite. Efficacy of the implant was evaluated by comparing results from the Voice Handicap Index (VHI) and mean airflow measurements before and 6 months after injection. Surgeon evaluations determined the comparative benefits of either endoscopic direct vocal fold injection or percutaneous vocal fold injection. Six-month data were obtained for a cohort of five patients. VHI scores improved for all five patients available for full evaluation and four of the five achieved improvements in mean airflow rates. Of the remaining patients, one later had a medialization laryngoplasty, two died from their terminal diseases before the 6-month follow-up, and two of the remaining three reported satisfaction with the results via telephone follow-up. Vocal fold injection via endoscopic, direct laryngoscopy was found to be a more reliable procedure for vocal fold injection than percutaneous injection. Slight overinjection (10% to 15%) was found to provide optimum results. Vocal fold injection of calcium hydroxylapatite for unilateral vocal fold paralysis improved voice quality and reduced mean airflow rates in this patient group with short-term results. Long-term studies are needed to confirm the durability of these findings.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Voice Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. rosenca@upmc.eduNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

15331112

Citation

Rosen, Clark A., and Apurva A. Thekdi. "Vocal Fold Augmentation With Injectable Calcium Hydroxylapatite: Short-term Results." Journal of Voice : Official Journal of the Voice Foundation, vol. 18, no. 3, 2004, pp. 387-91.
Rosen CA, Thekdi AA. Vocal fold augmentation with injectable calcium hydroxylapatite: short-term results. J Voice. 2004;18(3):387-91.
Rosen, C. A., & Thekdi, A. A. (2004). Vocal fold augmentation with injectable calcium hydroxylapatite: short-term results. Journal of Voice : Official Journal of the Voice Foundation, 18(3), 387-91.
Rosen CA, Thekdi AA. Vocal Fold Augmentation With Injectable Calcium Hydroxylapatite: Short-term Results. J Voice. 2004;18(3):387-91. PubMed PMID: 15331112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vocal fold augmentation with injectable calcium hydroxylapatite: short-term results. AU - Rosen,Clark A, AU - Thekdi,Apurva A, PY - 2004/02/03/accepted PY - 2004/8/28/pubmed PY - 2005/5/27/medline PY - 2004/8/28/entrez SP - 387 EP - 91 JF - Journal of voice : official journal of the Voice Foundation JO - J Voice VL - 18 IS - 3 N2 - Symptoms of unilateral vocal fold paralysis are improved significantly by augmenting the paralyzed vocal fold via vocal fold injection. In this trial, augmentation with a new calcium hydroxylapatite implant was evaluated. In addition, two different phonosurgical injection techniques were used, and these procedures were compared for accuracy and reliability. A total of 11 terminal patients with unilateral vocal fold paralysis underwent vocal fold injection with calcium hydroxylapatite. Efficacy of the implant was evaluated by comparing results from the Voice Handicap Index (VHI) and mean airflow measurements before and 6 months after injection. Surgeon evaluations determined the comparative benefits of either endoscopic direct vocal fold injection or percutaneous vocal fold injection. Six-month data were obtained for a cohort of five patients. VHI scores improved for all five patients available for full evaluation and four of the five achieved improvements in mean airflow rates. Of the remaining patients, one later had a medialization laryngoplasty, two died from their terminal diseases before the 6-month follow-up, and two of the remaining three reported satisfaction with the results via telephone follow-up. Vocal fold injection via endoscopic, direct laryngoscopy was found to be a more reliable procedure for vocal fold injection than percutaneous injection. Slight overinjection (10% to 15%) was found to provide optimum results. Vocal fold injection of calcium hydroxylapatite for unilateral vocal fold paralysis improved voice quality and reduced mean airflow rates in this patient group with short-term results. Long-term studies are needed to confirm the durability of these findings. SN - 0892-1997 UR - https://www.unboundmedicine.com/medline/citation/15331112/Vocal_fold_augmentation_with_injectable_calcium_hydroxylapatite:_short_term_results_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892199704000153 DB - PRIME DP - Unbound Medicine ER -