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PCDD/F and non-ortho PCB concentrations in adipose tissue of individuals living in the vicinity of a hazardous waste incinerator.
Chemosphere. 2004 Nov; 57(5):357-64.C

Abstract

To assess the influence of a new hazardous waste incinerator (HWI) on public health, a preoperational monitoring program was established during the period of construction. In this study, the levels of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) accumulated in adipose tissue of 15 autopsied subjects living in the area under potential impact of the HWI were determined after approximately 3 years of regular operations in the facility. The non-ortho PCBs 77, 126 and 169 were also determined. PCDD/F concentrations ranged between 1.5 and 41 pg WHO-TEQ/g fat (2.4 and 72 WHO-TEQ/g fat, respectively, including PCBs), with a mean value of 11 pg WHO-TEQ/g fat and a median value of 7.4 pg WHO-TEQ/g fat (22 and 13 WHO-TEQ/g fat, respectively, including PCBs). In the baseline study, the mean level of PCDD/Fs was 36 pg WHO-TEQ/g fat (61 pg WHO-TEQ/g fat, including non-ortho PCBs 77, 126 and 169), which means a reduction of 70% (64% including PCBs). This notable reduction is in accordance with the important decrease observed in recent years in PCDD/F intake through the diet. The current concentrations of PCDD/Fs in human adipose tissue, as well as recent data on PCDD/F levels in plasma and breast milk of subjects living in the vicinity of the same HWI, indicate that there is not any additional significant exposure to PCDD/Fs for this population.

Authors+Show Affiliations

Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, San Lorenzo 21, 43201 Reus, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15331262

Citation

Schuhmacher, Marta, et al. "PCDD/F and Non-ortho PCB Concentrations in Adipose Tissue of Individuals Living in the Vicinity of a Hazardous Waste Incinerator." Chemosphere, vol. 57, no. 5, 2004, pp. 357-64.
Schuhmacher M, Domingo JL, Hagberg J, et al. PCDD/F and non-ortho PCB concentrations in adipose tissue of individuals living in the vicinity of a hazardous waste incinerator. Chemosphere. 2004;57(5):357-64.
Schuhmacher, M., Domingo, J. L., Hagberg, J., & Lindström, G. (2004). PCDD/F and non-ortho PCB concentrations in adipose tissue of individuals living in the vicinity of a hazardous waste incinerator. Chemosphere, 57(5), 357-64.
Schuhmacher M, et al. PCDD/F and Non-ortho PCB Concentrations in Adipose Tissue of Individuals Living in the Vicinity of a Hazardous Waste Incinerator. Chemosphere. 2004;57(5):357-64. PubMed PMID: 15331262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PCDD/F and non-ortho PCB concentrations in adipose tissue of individuals living in the vicinity of a hazardous waste incinerator. AU - Schuhmacher,Marta, AU - Domingo,Jose L, AU - Hagberg,Jessika, AU - Lindström,Gunilla, PY - 2003/10/27/received PY - 2004/05/06/revised PY - 2004/05/31/accepted PY - 2004/8/28/pubmed PY - 2004/12/16/medline PY - 2004/8/28/entrez SP - 357 EP - 64 JF - Chemosphere JO - Chemosphere VL - 57 IS - 5 N2 - To assess the influence of a new hazardous waste incinerator (HWI) on public health, a preoperational monitoring program was established during the period of construction. In this study, the levels of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) accumulated in adipose tissue of 15 autopsied subjects living in the area under potential impact of the HWI were determined after approximately 3 years of regular operations in the facility. The non-ortho PCBs 77, 126 and 169 were also determined. PCDD/F concentrations ranged between 1.5 and 41 pg WHO-TEQ/g fat (2.4 and 72 WHO-TEQ/g fat, respectively, including PCBs), with a mean value of 11 pg WHO-TEQ/g fat and a median value of 7.4 pg WHO-TEQ/g fat (22 and 13 WHO-TEQ/g fat, respectively, including PCBs). In the baseline study, the mean level of PCDD/Fs was 36 pg WHO-TEQ/g fat (61 pg WHO-TEQ/g fat, including non-ortho PCBs 77, 126 and 169), which means a reduction of 70% (64% including PCBs). This notable reduction is in accordance with the important decrease observed in recent years in PCDD/F intake through the diet. The current concentrations of PCDD/Fs in human adipose tissue, as well as recent data on PCDD/F levels in plasma and breast milk of subjects living in the vicinity of the same HWI, indicate that there is not any additional significant exposure to PCDD/Fs for this population. SN - 0045-6535 UR - https://www.unboundmedicine.com/medline/citation/15331262/PCDD/F_and_non_ortho_PCB_concentrations_in_adipose_tissue_of_individuals_living_in_the_vicinity_of_a_hazardous_waste_incinerator_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(04)00466-7 DB - PRIME DP - Unbound Medicine ER -