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Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats.
Indian J Exp Biol. 2003 Nov; 41(11):1285-8.IJ

Abstract

A study was undertaken to evaluate the anti-lipid peroxidative activity of an aqueous extract of A. marmelos fruits (AMFEt) in streptozotocin diabetic rats in heart and pancreas. Oral administration of AMFEt for 30 days (125 and 250 mg kg(-1) body weight twice daily) produced a significant decrease in the elevated levels of peroxidation products, viz. thiobarbituric acid reactive substances and hydroperoxides in the tissues of diabetic rats. The depressed activities of superoxide dismutase, catalase and glutathione peroxidase and lowered glutathione content in the heart and pancreas of diabetic rats were found to increase on treatment with AMFEt. AMFEt at a dose of 250 mg kg(-1) was more effective than glibenclamide (300 microg kg(-1)) and both reversed all the values significantly. Thus AMFEt exhibits anti-oxidative activity in streptozotocin diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, Annamalai University, Annamalai Nagar 608 002, India.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15332498

Citation

Kamalakkannan, N, and P Stanely Mainzen Prince. "Effect of Aegle Marmelos Correa. (Bael) Fruit Extract On Tissue Antioxidants in Streptozotocin Diabetic Rats." Indian Journal of Experimental Biology, vol. 41, no. 11, 2003, pp. 1285-8.
Kamalakkannan N, Stanely Mainzen Prince P. Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats. Indian J Exp Biol. 2003;41(11):1285-8.
Kamalakkannan, N., & Stanely Mainzen Prince, P. (2003). Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats. Indian Journal of Experimental Biology, 41(11), 1285-8.
Kamalakkannan N, Stanely Mainzen Prince P. Effect of Aegle Marmelos Correa. (Bael) Fruit Extract On Tissue Antioxidants in Streptozotocin Diabetic Rats. Indian J Exp Biol. 2003;41(11):1285-8. PubMed PMID: 15332498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats. AU - Kamalakkannan,N, AU - Stanely Mainzen Prince,P, PY - 2004/8/31/pubmed PY - 2004/9/17/medline PY - 2004/8/31/entrez SP - 1285 EP - 8 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 41 IS - 11 N2 - A study was undertaken to evaluate the anti-lipid peroxidative activity of an aqueous extract of A. marmelos fruits (AMFEt) in streptozotocin diabetic rats in heart and pancreas. Oral administration of AMFEt for 30 days (125 and 250 mg kg(-1) body weight twice daily) produced a significant decrease in the elevated levels of peroxidation products, viz. thiobarbituric acid reactive substances and hydroperoxides in the tissues of diabetic rats. The depressed activities of superoxide dismutase, catalase and glutathione peroxidase and lowered glutathione content in the heart and pancreas of diabetic rats were found to increase on treatment with AMFEt. AMFEt at a dose of 250 mg kg(-1) was more effective than glibenclamide (300 microg kg(-1)) and both reversed all the values significantly. Thus AMFEt exhibits anti-oxidative activity in streptozotocin diabetic rats. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/15332498/Effect_of_Aegle_marmelos_Correa___Bael__fruit_extract_on_tissue_antioxidants_in_streptozotocin_diabetic_rats_ L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -