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Inhibition of platelet function by hydroxyethyl starch solutions in chronic pain patients undergoing peridural anesthesia.
Anesth Analg. 2004 Sep; 99(3):823-7, table of contents.A&A

Abstract

The use of hydroxyethyl starch (HES) solutions as a fluid replacement before peridural blockade may compromise blood coagulation, thus increasing the risk of neuraxial bleeding. In this prospective, double-blind, placebo-controlled, crossover study, we compared the influence of HES 130 (molecular weight in kilodalton), HES 200, and lactated Ringer's solution on platelet function and hemodynamics in chronic low back pain patients scheduled for peridural blockades. Patients received 3 test infusions of 10 mL/kg each administered IV for 30 min. Collagen/epinephrine and collagen/adenosine diphosphate were used as agonists for assessment of platelet function analyzer-closure times. Arterial blood pressure, heart rate, platelet counts, and hemoglobin levels were documented. Platelet function analyzer-closure times remained stable after lactated Ringer's solution but were significantly prolonged after HES. The platelet-inhibiting effect of HES 200 was more than that of HES 130. Hemodynamic stability was sufficiently maintained by all test infusions. In contrast to previous observations, a relevant antiplatelet effect of both low and medium molecular weight HES solutions was found in this study in chronic pain patients undergoing peridural anesthesia. Because hemostasiological competence is a prerequisite for safe neuraxial blockade, the decision of HES for intravascular fluid administration before blockade should be critically made.

Authors+Show Affiliations

Department of Anesthesiology and Intensive Care, University of Vienna, Währinger Gürtel 18-20, 1090-Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15333417

Citation

Scharbert, Gisela, et al. "Inhibition of Platelet Function By Hydroxyethyl Starch Solutions in Chronic Pain Patients Undergoing Peridural Anesthesia." Anesthesia and Analgesia, vol. 99, no. 3, 2004, 823-7, table of contents.
Scharbert G, Deusch E, Kress HG, et al. Inhibition of platelet function by hydroxyethyl starch solutions in chronic pain patients undergoing peridural anesthesia. Anesth Analg. 2004;99(3):823-7, table of contents.
Scharbert, G., Deusch, E., Kress, H. G., Greher, M., Gustorff, B., & Kozek-Langenecker, S. A. (2004). Inhibition of platelet function by hydroxyethyl starch solutions in chronic pain patients undergoing peridural anesthesia. Anesthesia and Analgesia, 99(3), 823-7, table of contents.
Scharbert G, et al. Inhibition of Platelet Function By Hydroxyethyl Starch Solutions in Chronic Pain Patients Undergoing Peridural Anesthesia. Anesth Analg. 2004;99(3):823-7, table of contents. PubMed PMID: 15333417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of platelet function by hydroxyethyl starch solutions in chronic pain patients undergoing peridural anesthesia. AU - Scharbert,Gisela, AU - Deusch,Engelbert, AU - Kress,Hans Georg, AU - Greher,Manfred, AU - Gustorff,Burkhard, AU - Kozek-Langenecker,Sibylle A, PY - 2004/8/31/pubmed PY - 2004/9/24/medline PY - 2004/8/31/entrez SP - 823-7, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 99 IS - 3 N2 - The use of hydroxyethyl starch (HES) solutions as a fluid replacement before peridural blockade may compromise blood coagulation, thus increasing the risk of neuraxial bleeding. In this prospective, double-blind, placebo-controlled, crossover study, we compared the influence of HES 130 (molecular weight in kilodalton), HES 200, and lactated Ringer's solution on platelet function and hemodynamics in chronic low back pain patients scheduled for peridural blockades. Patients received 3 test infusions of 10 mL/kg each administered IV for 30 min. Collagen/epinephrine and collagen/adenosine diphosphate were used as agonists for assessment of platelet function analyzer-closure times. Arterial blood pressure, heart rate, platelet counts, and hemoglobin levels were documented. Platelet function analyzer-closure times remained stable after lactated Ringer's solution but were significantly prolonged after HES. The platelet-inhibiting effect of HES 200 was more than that of HES 130. Hemodynamic stability was sufficiently maintained by all test infusions. In contrast to previous observations, a relevant antiplatelet effect of both low and medium molecular weight HES solutions was found in this study in chronic pain patients undergoing peridural anesthesia. Because hemostasiological competence is a prerequisite for safe neuraxial blockade, the decision of HES for intravascular fluid administration before blockade should be critically made. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/15333417/Inhibition_of_platelet_function_by_hydroxyethyl_starch_solutions_in_chronic_pain_patients_undergoing_peridural_anesthesia_ L2 - https://doi.org/10.1213/01.ANE.0000131973.99804.61 DB - PRIME DP - Unbound Medicine ER -