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Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding.
Aliment Pharmacol Ther. 2004 Sep; 20 Suppl 3:8-15; discussion 16-7.AP

Abstract

Gastro-oesophageal variceal bleeding is the last step in a chain of events that starts with an increased portal pressure, and is followed by the formation and progressive dilatation of gastro-oesophageal varices. When the tension of the thin wall of the varices exceeds its elastic limit, the varices rupture and bleed. Wall tension is directly proportional to variceal pressure (which is a function of portal pressure) and variceal radius, and inversely related to the thickness of the variceal wall. The above facts explain why a high portal pressure (usually determined by the hepatic venous pressure gradient, or HVPG) and the presence at endoscopy of large varices with red wheals, red spots or diffuse redness on the varices (signalling a reduced wall thickness) correlate with the risk of bleeding.

Authors+Show Affiliations

Liver Unit, Institut de Malalties Digestives i Metabòliques, Hospital Clínic, University of Barcelona, Spain.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15335392

Citation

Dell'era, A, and J Bosch. "Review Article: the Relevance of Portal Pressure and Other Risk Factors in Acute Gastro-oesophageal Variceal Bleeding." Alimentary Pharmacology & Therapeutics, vol. 20 Suppl 3, 2004, pp. 8-15; discussion 16-7.
Dell'era A, Bosch J. Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding. Aliment Pharmacol Ther. 2004;20 Suppl 3:8-15; discussion 16-7.
Dell'era, A., & Bosch, J. (2004). Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding. Alimentary Pharmacology & Therapeutics, 20 Suppl 3, 8-15; discussion 16-7.
Dell'era A, Bosch J. Review Article: the Relevance of Portal Pressure and Other Risk Factors in Acute Gastro-oesophageal Variceal Bleeding. Aliment Pharmacol Ther. 2004;20 Suppl 3:8-15; discussion 16-7. PubMed PMID: 15335392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review article: the relevance of portal pressure and other risk factors in acute gastro-oesophageal variceal bleeding. AU - Dell'era,A, AU - Bosch,J, PY - 2004/9/1/pubmed PY - 2004/12/18/medline PY - 2004/9/1/entrez SP - 8-15; discussion 16-7 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 20 Suppl 3 N2 - Gastro-oesophageal variceal bleeding is the last step in a chain of events that starts with an increased portal pressure, and is followed by the formation and progressive dilatation of gastro-oesophageal varices. When the tension of the thin wall of the varices exceeds its elastic limit, the varices rupture and bleed. Wall tension is directly proportional to variceal pressure (which is a function of portal pressure) and variceal radius, and inversely related to the thickness of the variceal wall. The above facts explain why a high portal pressure (usually determined by the hepatic venous pressure gradient, or HVPG) and the presence at endoscopy of large varices with red wheals, red spots or diffuse redness on the varices (signalling a reduced wall thickness) correlate with the risk of bleeding. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15335392/Review_article:_the_relevance_of_portal_pressure_and_other_risk_factors_in_acute_gastro_oesophageal_variceal_bleeding_ L2 - https://doi.org/10.1111/j.1365-2036.2004.02109.x DB - PRIME DP - Unbound Medicine ER -