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Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation.
Eur Neuropsychopharmacol. 2004 Oct; 14(5):373-9.EN

Abstract

Prepulse inhibition of startle is a model of sensorimotor gating, which is disrupted in alcoholism, as well as mental illnesses such as schizophrenia. The fawn-hooded (FH) rat strain has been used as an animal model of alcoholism. FH rats showed significantly lower startle amplitude than Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats. Increasing doses of the 5-HT(1A) receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. In contrast, 0.1 mg/kg of 8-OH-DPAT caused disruption only in the FH strain. Treatment with amphetamine, apomorphine and MK-801 also significantly reduced PPI, however, there was no difference between the strains. This study shows increased sensitivity of FH rats to the disruption of PPI caused by 5-HT(1A) receptor stimulation, suggesting a link between 5-HT(1A) receptors, sensorimotor gating and aspects of the FH rat phenotype.

Authors+Show Affiliations

Martin S
Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria 3052, Australia.
Lawrence AJ
No affiliation info available
van den Buuse M
No affiliation info available

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAmphetamineAnimalsApomorphineDizocilpine MaleateDopamine AgonistsDopamine Uptake InhibitorsDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsNeural InhibitionRatsRats, Inbred StrainsRats, Inbred WKYRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReflex, StartleSerotonin Receptor AgonistsSpecies Specificity

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15336298

Citation

Martin, Sally, et al. "Prepulse Inhibition in Fawn-hooded Rats: Increased Sensitivity to 5-HT1A Receptor Stimulation." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 14, no. 5, 2004, pp. 373-9.
Martin S, Lawrence AJ, van den Buuse M. Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation. Eur Neuropsychopharmacol. 2004;14(5):373-9.
Martin, S., Lawrence, A. J., & van den Buuse, M. (2004). Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 14(5), 373-9.
Martin S, Lawrence AJ, van den Buuse M. Prepulse Inhibition in Fawn-hooded Rats: Increased Sensitivity to 5-HT1A Receptor Stimulation. Eur Neuropsychopharmacol. 2004;14(5):373-9. PubMed PMID: 15336298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prepulse inhibition in fawn-hooded rats: increased sensitivity to 5-HT1A receptor stimulation. AU - Martin,Sally, AU - Lawrence,Andrew J, AU - van den Buuse,Maarten, PY - 2003/06/17/received PY - 2003/09/30/revised PY - 2003/10/28/accepted PY - 2004/9/1/pubmed PY - 2004/12/16/medline PY - 2004/9/1/entrez SP - 373 EP - 9 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 14 IS - 5 N2 - Prepulse inhibition of startle is a model of sensorimotor gating, which is disrupted in alcoholism, as well as mental illnesses such as schizophrenia. The fawn-hooded (FH) rat strain has been used as an animal model of alcoholism. FH rats showed significantly lower startle amplitude than Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats. Increasing doses of the 5-HT(1A) receptor agonist 8-OH-DPAT caused disruption of PPI, with the effect being significantly greater in FH rats compared to WKY rats. In all strains, treatment with 0.5 mg/kg of 8-OH-DPAT significantly reduced PPI. In contrast, 0.1 mg/kg of 8-OH-DPAT caused disruption only in the FH strain. Treatment with amphetamine, apomorphine and MK-801 also significantly reduced PPI, however, there was no difference between the strains. This study shows increased sensitivity of FH rats to the disruption of PPI caused by 5-HT(1A) receptor stimulation, suggesting a link between 5-HT(1A) receptors, sensorimotor gating and aspects of the FH rat phenotype. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/15336298/Prepulse_inhibition_in_fawn_hooded_rats:_increased_sensitivity_to_5_HT1A_receptor_stimulation_ DB - PRIME DP - Unbound Medicine ER -