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Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women.
Bone. 2004 Sep; 35(3):589-94.BONE

Abstract

Neuropeptide Y (NPY) is a versatile neurotransmitter that has recently been shown to regulate bone metabolism in animal and in vitro studies. We studied the influence of leucine7-to-proline7 (Leu7/Pro7) polymorphism of the NPY signal peptide gene on bone mineral density (BMD) before and after a 5-year hormone replacement therapy (HRT) in 316 early postmenopausal women participating in a randomized controlled trial nested in the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study. The participants were randomized into two treatment groups: the HRT group (n = 146) received a sequential combination of 2 mg estradiol valerate and 1 mg cyproterone acetate and calcium lactate, 500 mg/day (equal to 93 mg Ca2+) alone or in combination with vitamin D3, 100-300 IU/day. The non-HRT group (n = 170) received calcium lactate, 500 mg alone or in combination with vitamin D3, 100-300 IU/day. BMDs of the lumbar spine (L2-4) and proximal femur were measured by using dual X-ray absorptiometry (DXA). The frequency of Leu7/Pro7 polymorphism was 15.2%. At baseline, there were no significant differences in the lumbar or femoral neck BMD between the subjects who had Leu7Pro7 polymorphism and the normal subjects. After 5 years, the BMD of the femoral neck remained unaltered and that of the lumbar spine increased by 1.7% in the HRT group, whereas both BMDs were decreased by 4-5% in the non-HRT group. After 5 years, the femoral neck BMD was significantly lower in those with the wild-type NPY polymorphism than in those with Leu7/Pro7 polymorphism (P = 0.040) in the non-HRT group. In the HRT group, the changes in BMD were quite modest and not significantly modified by Leu7/Pro7 genotype. We conclude that the Leu7/Pro7 polymorphism in NPY signal gene may favorably affect femoral neck BMD in postmenopausal women.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kuopio University Hospital, FIN-70211 Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15336593

Citation

Heikkinen, Anna-Mari, et al. "Leucine7 to Proline7 Polymorphism in prepro-NPY Gene and Femoral Neck Bone Mineral Density in Postmenopausal Women." Bone, vol. 35, no. 3, 2004, pp. 589-94.
Heikkinen AM, Niskanen LK, Salmi JA, et al. Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women. Bone. 2004;35(3):589-94.
Heikkinen, A. M., Niskanen, L. K., Salmi, J. A., Koulu, M., Pesonen, U., Uusitupa, M. I., Komulainen, M. H., Tuppurainen, M. T., Kröger, H., Jurvelin, J., & Saarikoski, S. (2004). Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women. Bone, 35(3), 589-94.
Heikkinen AM, et al. Leucine7 to Proline7 Polymorphism in prepro-NPY Gene and Femoral Neck Bone Mineral Density in Postmenopausal Women. Bone. 2004;35(3):589-94. PubMed PMID: 15336593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leucine7 to proline7 polymorphism in prepro-NPY gene and femoral neck bone mineral density in postmenopausal women. AU - Heikkinen,Anna-Mari, AU - Niskanen,Leo K, AU - Salmi,Jukka A, AU - Koulu,Markku, AU - Pesonen,Ullamari, AU - Uusitupa,Matti I J, AU - Komulainen,Marja H, AU - Tuppurainen,Marjo T, AU - Kröger,Heikki, AU - Jurvelin,Jukka, AU - Saarikoski,Seppo, PY - 2003/12/11/received PY - 2004/04/02/revised PY - 2004/05/05/accepted PY - 2004/9/1/pubmed PY - 2005/3/23/medline PY - 2004/9/1/entrez SP - 589 EP - 94 JF - Bone JO - Bone VL - 35 IS - 3 N2 - Neuropeptide Y (NPY) is a versatile neurotransmitter that has recently been shown to regulate bone metabolism in animal and in vitro studies. We studied the influence of leucine7-to-proline7 (Leu7/Pro7) polymorphism of the NPY signal peptide gene on bone mineral density (BMD) before and after a 5-year hormone replacement therapy (HRT) in 316 early postmenopausal women participating in a randomized controlled trial nested in the population-based Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) study. The participants were randomized into two treatment groups: the HRT group (n = 146) received a sequential combination of 2 mg estradiol valerate and 1 mg cyproterone acetate and calcium lactate, 500 mg/day (equal to 93 mg Ca2+) alone or in combination with vitamin D3, 100-300 IU/day. The non-HRT group (n = 170) received calcium lactate, 500 mg alone or in combination with vitamin D3, 100-300 IU/day. BMDs of the lumbar spine (L2-4) and proximal femur were measured by using dual X-ray absorptiometry (DXA). The frequency of Leu7/Pro7 polymorphism was 15.2%. At baseline, there were no significant differences in the lumbar or femoral neck BMD between the subjects who had Leu7Pro7 polymorphism and the normal subjects. After 5 years, the BMD of the femoral neck remained unaltered and that of the lumbar spine increased by 1.7% in the HRT group, whereas both BMDs were decreased by 4-5% in the non-HRT group. After 5 years, the femoral neck BMD was significantly lower in those with the wild-type NPY polymorphism than in those with Leu7/Pro7 polymorphism (P = 0.040) in the non-HRT group. In the HRT group, the changes in BMD were quite modest and not significantly modified by Leu7/Pro7 genotype. We conclude that the Leu7/Pro7 polymorphism in NPY signal gene may favorably affect femoral neck BMD in postmenopausal women. SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/15336593/Leucine7_to_proline7_polymorphism_in_prepro_NPY_gene_and_femoral_neck_bone_mineral_density_in_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756328204002078 DB - PRIME DP - Unbound Medicine ER -