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Common carotid artery intima media thickness and post-stroke cognitive impairment.
J Neurol Sci. 2004 Aug 30; 223(2):129-34.JN

Abstract

BACKGROUND AND PURPOSE

Acute stroke and other forms of cerebrovascular disease are well-recognized causes of cognitive impairment. Common carotid artery intima media thickness (CCA-IMT) has been associated with certain forms of cerebrovascular disease, but its association with cognitive impairment of vascular origin has not been elucidated. The purpose of this study was to investigate whether CCA-IMT is associated with cognitive impairment 1 year after an acute ischemic stroke.

METHODS

A total of 171 consecutive patients with the first ever stroke (mean age 66+/-11.5, 41% female) underwent carotid ultrasonography during hospitalization. Demographic data, vascular risk factors and presenting stroke features were also recorded. One year later, patients' cognitive performance and depression were assessed using the Mini-Mental State Examination (MMSE), and the Montgomery Asberg Depression Rating Scale (MADRS).

RESULTS

Cognitive impairment (MMSE score<24) was found in 67 (39%) of the 171 patients. CCA-IMT was significantly associated with cognitive impairment, and this association remained unchanged (OR 1.94; 95% CI 1.19-3.18) after adjustment for demographic data, vascular risk factors, stroke features, other carotid ultrasonography measurements and depression. Older age, low education level, large hemispheric lesions, hyperdense carotid plaques and depression were also independently associated with post-stroke cognitive impairment.

CONCLUSIONS

In this study, CCA-IMT was independently associated with cognitive impairment 1 year after an acute ischemic stroke, and thus, it might help with the screening of stroke patients at risk of cognitive impairment.

Authors+Show Affiliations

Department of Neurology, University Hospital of Patras, P.O. Box 1045, 26500 Rio, Patras, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15337613

Citation

Talelli, P, et al. "Common Carotid Artery Intima Media Thickness and Post-stroke Cognitive Impairment." Journal of the Neurological Sciences, vol. 223, no. 2, 2004, pp. 129-34.
Talelli P, Ellul J, Terzis G, et al. Common carotid artery intima media thickness and post-stroke cognitive impairment. J Neurol Sci. 2004;223(2):129-34.
Talelli, P., Ellul, J., Terzis, G., Lekka, N. P., Gioldasis, G., Chrysanthopoulou, A., & Papapetropoulos, T. (2004). Common carotid artery intima media thickness and post-stroke cognitive impairment. Journal of the Neurological Sciences, 223(2), 129-34.
Talelli P, et al. Common Carotid Artery Intima Media Thickness and Post-stroke Cognitive Impairment. J Neurol Sci. 2004 Aug 30;223(2):129-34. PubMed PMID: 15337613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Common carotid artery intima media thickness and post-stroke cognitive impairment. AU - Talelli,P, AU - Ellul,J, AU - Terzis,G, AU - Lekka,N P, AU - Gioldasis,G, AU - Chrysanthopoulou,A, AU - Papapetropoulos,Th, PY - 2003/10/10/received PY - 2004/05/05/revised PY - 2004/05/05/accepted PY - 2004/9/1/pubmed PY - 2004/11/16/medline PY - 2004/9/1/entrez SP - 129 EP - 34 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 223 IS - 2 N2 - BACKGROUND AND PURPOSE: Acute stroke and other forms of cerebrovascular disease are well-recognized causes of cognitive impairment. Common carotid artery intima media thickness (CCA-IMT) has been associated with certain forms of cerebrovascular disease, but its association with cognitive impairment of vascular origin has not been elucidated. The purpose of this study was to investigate whether CCA-IMT is associated with cognitive impairment 1 year after an acute ischemic stroke. METHODS: A total of 171 consecutive patients with the first ever stroke (mean age 66+/-11.5, 41% female) underwent carotid ultrasonography during hospitalization. Demographic data, vascular risk factors and presenting stroke features were also recorded. One year later, patients' cognitive performance and depression were assessed using the Mini-Mental State Examination (MMSE), and the Montgomery Asberg Depression Rating Scale (MADRS). RESULTS: Cognitive impairment (MMSE score<24) was found in 67 (39%) of the 171 patients. CCA-IMT was significantly associated with cognitive impairment, and this association remained unchanged (OR 1.94; 95% CI 1.19-3.18) after adjustment for demographic data, vascular risk factors, stroke features, other carotid ultrasonography measurements and depression. Older age, low education level, large hemispheric lesions, hyperdense carotid plaques and depression were also independently associated with post-stroke cognitive impairment. CONCLUSIONS: In this study, CCA-IMT was independently associated with cognitive impairment 1 year after an acute ischemic stroke, and thus, it might help with the screening of stroke patients at risk of cognitive impairment. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15337613/Common_carotid_artery_intima_media_thickness_and_post_stroke_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X04001728 DB - PRIME DP - Unbound Medicine ER -