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Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease.
J Neurol Sci 2004; 223(2):161-6JN

Abstract

Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients.

Authors+Show Affiliations

Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. sohmiyam@med.gunma-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15337618

Citation

Sohmiya, Makoto, et al. "Redox Status of Plasma Coenzyme Q10 Indicates Elevated Systemic Oxidative Stress in Parkinson's Disease." Journal of the Neurological Sciences, vol. 223, no. 2, 2004, pp. 161-6.
Sohmiya M, Tanaka M, Tak NW, et al. Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. J Neurol Sci. 2004;223(2):161-6.
Sohmiya, M., Tanaka, M., Tak, N. W., Yanagisawa, M., Tanino, Y., Suzuki, Y., ... Yamamoto, Y. (2004). Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. Journal of the Neurological Sciences, 223(2), pp. 161-6.
Sohmiya M, et al. Redox Status of Plasma Coenzyme Q10 Indicates Elevated Systemic Oxidative Stress in Parkinson's Disease. J Neurol Sci. 2004 Aug 30;223(2):161-6. PubMed PMID: 15337618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease. AU - Sohmiya,Makoto, AU - Tanaka,Makoto, AU - Tak,Nyou Wei, AU - Yanagisawa,Makoto, AU - Tanino,Yutaka, AU - Suzuki,Yoko, AU - Okamoto,Koichi, AU - Yamamoto,Yorihiro, PY - 2003/07/21/received PY - 2004/02/20/revised PY - 2004/05/11/accepted PY - 2004/9/1/pubmed PY - 2004/11/16/medline PY - 2004/9/1/entrez SP - 161 EP - 6 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 223 IS - 2 N2 - Oxidative stress is suggested to play an important role in the pathogenesis of Parkinson's disease (PD). However, no elevation of plasma oxidative stress marker has been reported. We measured percent content of the oxidized form of coenzyme Q10 in total coenzyme Q10 (%CoQ-10) because %CoQ-10 has been shown to be a sensitive marker of oxidative stress. A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/15337618/Redox_status_of_plasma_coenzyme_Q10_indicates_elevated_systemic_oxidative_stress_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X04001662 DB - PRIME DP - Unbound Medicine ER -