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Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study.
Am J Psychiatry 2004; 161(9):1603-11AJ

Abstract

OBJECTIVE

The middle temporal gyrus and inferior temporal gyrus subserve language and semantic memory processing, visual perception, and multimodal sensory integration. Functional deficits in these cognitive processes have been well documented in patients with schizophrenia. However, there have been few in vivo structural magnetic resonance imaging (MRI) studies of the middle temporal gyrus and inferior temporal gyrus in schizophrenia.

METHOD

Middle temporal gyrus and inferior temporal gyrus gray matter volumes were measured in 23 male patients diagnosed with chronic schizophrenia and 28 healthy male subjects by using high-spatial-resolution MRI. For comparison, superior temporal gyrus and fusiform gyrus gray matter volumes were also measured. Correlations between these four regions and clinical symptoms were also investigated.

RESULTS

Relative to healthy subjects, the patients with chronic schizophrenia showed gray matter volume reductions in the left middle temporal gyrus (13% difference) and bilateral inferior temporal gyrus (10% difference in both hemispheres). In addition, the patients showed gray matter volume reductions in the left superior temporal gyrus (13% difference) and bilateral fusiform gyrus (10% difference in both hemispheres). More severe hallucinations were significantly correlated with smaller left hemisphere volumes in the superior temporal gyrus and middle temporal gyrus.

CONCLUSIONS

These results suggest that patients with schizophrenia evince reduced gray matter volume in the left middle temporal gyrus and bilateral reductions in the inferior temporal gyrus. In conjunction with findings of left superior temporal gyrus reduction and bilateral fusiform gyrus reductions, these data suggest that schizophrenia may be characterized by left hemisphere-selective dorsal pathophysiology and bilateral ventral pathophysiology in temporal lobe gray matter.

Authors+Show Affiliations

Department of Psychiatry (116A), Boston VA Healthcare System, Brockton Division, Harvard Medical School, 940 Belmont St., Brockton, MA 02301, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15337650

Citation

Onitsuka, Toshiaki, et al. "Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in Chronic Schizophrenia: an MRI Study." The American Journal of Psychiatry, vol. 161, no. 9, 2004, pp. 1603-11.
Onitsuka T, Shenton ME, Salisbury DF, et al. Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. Am J Psychiatry. 2004;161(9):1603-11.
Onitsuka, T., Shenton, M. E., Salisbury, D. F., Dickey, C. C., Kasai, K., Toner, S. K., ... McCarley, R. W. (2004). Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. The American Journal of Psychiatry, 161(9), pp. 1603-11.
Onitsuka T, et al. Middle and Inferior Temporal Gyrus Gray Matter Volume Abnormalities in Chronic Schizophrenia: an MRI Study. Am J Psychiatry. 2004;161(9):1603-11. PubMed PMID: 15337650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. AU - Onitsuka,Toshiaki, AU - Shenton,Martha E, AU - Salisbury,Dean F, AU - Dickey,Chandlee C, AU - Kasai,Kiyoto, AU - Toner,Sarah K, AU - Frumin,Melissa, AU - Kikinis,Ron, AU - Jolesz,Ferenc A, AU - McCarley,Robert W, PY - 2004/9/1/pubmed PY - 2004/10/8/medline PY - 2004/9/1/entrez SP - 1603 EP - 11 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 161 IS - 9 N2 - OBJECTIVE: The middle temporal gyrus and inferior temporal gyrus subserve language and semantic memory processing, visual perception, and multimodal sensory integration. Functional deficits in these cognitive processes have been well documented in patients with schizophrenia. However, there have been few in vivo structural magnetic resonance imaging (MRI) studies of the middle temporal gyrus and inferior temporal gyrus in schizophrenia. METHOD: Middle temporal gyrus and inferior temporal gyrus gray matter volumes were measured in 23 male patients diagnosed with chronic schizophrenia and 28 healthy male subjects by using high-spatial-resolution MRI. For comparison, superior temporal gyrus and fusiform gyrus gray matter volumes were also measured. Correlations between these four regions and clinical symptoms were also investigated. RESULTS: Relative to healthy subjects, the patients with chronic schizophrenia showed gray matter volume reductions in the left middle temporal gyrus (13% difference) and bilateral inferior temporal gyrus (10% difference in both hemispheres). In addition, the patients showed gray matter volume reductions in the left superior temporal gyrus (13% difference) and bilateral fusiform gyrus (10% difference in both hemispheres). More severe hallucinations were significantly correlated with smaller left hemisphere volumes in the superior temporal gyrus and middle temporal gyrus. CONCLUSIONS: These results suggest that patients with schizophrenia evince reduced gray matter volume in the left middle temporal gyrus and bilateral reductions in the inferior temporal gyrus. In conjunction with findings of left superior temporal gyrus reduction and bilateral fusiform gyrus reductions, these data suggest that schizophrenia may be characterized by left hemisphere-selective dorsal pathophysiology and bilateral ventral pathophysiology in temporal lobe gray matter. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/15337650/Middle_and_inferior_temporal_gyrus_gray_matter_volume_abnormalities_in_chronic_schizophrenia:_an_MRI_study_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.161.9.1603?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -