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Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats.
Psychopharmacology (Berl). 2004 Dec; 177(1-2):100-10.P

Abstract

RATIONALE

There is a large body of evidence indicating that the mesoaccumbens dopamine pathway is critically involved in the expression of behavioral sensitization to amphetamine and cocaine, but its role in the development of sensitization to psychostimulants is not that sound. Very few studies, however, have examined the role of dopamine transmission in 3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization.

OBJECTIVES

The effects of the D1 receptor antagonist SCH 23390 on the development and expression of MDMA-induced behavioral sensitization were investigated in rats.

METHODS

During the development phase of sensitization, SCH 23390 was administered 15 min before every administration of MDMA. After 12 days of withdrawal, a MDMA challenge dose was given and locomotor activity was measured. In separate experiments, 15 min before the challenge injection of MDMA, SCH 23390 was administered either systemically or directly into the core of the nucleus accumbens (NAc) of MDMA-pretreated rats.

RESULTS

SCH 23390 did not prevent the development of MDMA-induced behavioral sensitization but completely blocked the expression when given before the challenge dose of MDMA. The same results were obtained when SCH 23390 was locally applied into the core of the NAc.

CONCLUSIONS

The present data suggest that D1 receptor stimulation is not critical for the development of long-term MDMA sensitization, in agreement with what has been reported for cocaine. By contrast, expression of sensitization depends on the activation of D1 receptors located in the NAc core.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, University of Navarra, C/Irunlarrea, 1, 31008 Pamplona, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15338099

Citation

Ramos, María, et al. "Studies On the Role of Dopamine D1 Receptors in the Development and Expression of MDMA-induced Behavioral Sensitization in Rats." Psychopharmacology, vol. 177, no. 1-2, 2004, pp. 100-10.
Ramos M, Goñi-Allo B, Aguirre N. Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats. Psychopharmacology (Berl). 2004;177(1-2):100-10.
Ramos, M., Goñi-Allo, B., & Aguirre, N. (2004). Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats. Psychopharmacology, 177(1-2), 100-10.
Ramos M, Goñi-Allo B, Aguirre N. Studies On the Role of Dopamine D1 Receptors in the Development and Expression of MDMA-induced Behavioral Sensitization in Rats. Psychopharmacology (Berl). 2004;177(1-2):100-10. PubMed PMID: 15338099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the role of dopamine D1 receptors in the development and expression of MDMA-induced behavioral sensitization in rats. AU - Ramos,María, AU - Goñi-Allo,Beatriz, AU - Aguirre,Norberto, Y1 - 2004/08/27/ PY - 2003/09/30/received PY - 2004/05/14/accepted PY - 2004/9/1/pubmed PY - 2005/3/24/medline PY - 2004/9/1/entrez SP - 100 EP - 10 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 177 IS - 1-2 N2 - RATIONALE: There is a large body of evidence indicating that the mesoaccumbens dopamine pathway is critically involved in the expression of behavioral sensitization to amphetamine and cocaine, but its role in the development of sensitization to psychostimulants is not that sound. Very few studies, however, have examined the role of dopamine transmission in 3,4-methylenedioxymethamphetamine (MDMA)-induced sensitization. OBJECTIVES: The effects of the D1 receptor antagonist SCH 23390 on the development and expression of MDMA-induced behavioral sensitization were investigated in rats. METHODS: During the development phase of sensitization, SCH 23390 was administered 15 min before every administration of MDMA. After 12 days of withdrawal, a MDMA challenge dose was given and locomotor activity was measured. In separate experiments, 15 min before the challenge injection of MDMA, SCH 23390 was administered either systemically or directly into the core of the nucleus accumbens (NAc) of MDMA-pretreated rats. RESULTS: SCH 23390 did not prevent the development of MDMA-induced behavioral sensitization but completely blocked the expression when given before the challenge dose of MDMA. The same results were obtained when SCH 23390 was locally applied into the core of the NAc. CONCLUSIONS: The present data suggest that D1 receptor stimulation is not critical for the development of long-term MDMA sensitization, in agreement with what has been reported for cocaine. By contrast, expression of sensitization depends on the activation of D1 receptors located in the NAc core. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/15338099/Studies_on_the_role_of_dopamine_D1_receptors_in_the_development_and_expression_of_MDMA_induced_behavioral_sensitization_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-004-1937-0 DB - PRIME DP - Unbound Medicine ER -