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Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation.
Cell Tissue Res. 2004 Oct; 318(1):149-61.CT

Abstract

Parkinson's disease (PD) is a frequent neurological disorder of the basal ganglia, which is characterized by the progressive loss of dopaminergic neurons mainly in the substantia nigra pars compacta (SNpc). Inflammatory processes have been shown to be associated with the pathogenesis of PD. Activated microglia, as well as to a lesser extent reactive astrocytes, are found in the area associated with cell loss, possibly contributing to the inflammatory process by the release of pro-inflammatory prostaglandins or cytokines. Further deleterious factors released by activated microglia or astrocytes are reactive oxygen species. On the other hand, they may mediate neuroprotective properties by the release of trophic factors or the uptake of glutamate. In this review, we will discuss the different aspects of activated glial cells and potential mechanisms that mediate or protect against cell loss in PD.

Authors+Show Affiliations

Neurodegeneration Laboratory, Department of General Neurology, Center of Neurology and Hertie Institute for Clinical Brain Research, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany. peter.teismann@uni-tuebingen.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15338271

Citation

Teismann, Peter, and Jörg B. Schulz. "Cellular Pathology of Parkinson's Disease: Astrocytes, Microglia and Inflammation." Cell and Tissue Research, vol. 318, no. 1, 2004, pp. 149-61.
Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 2004;318(1):149-61.
Teismann, P., & Schulz, J. B. (2004). Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell and Tissue Research, 318(1), 149-61.
Teismann P, Schulz JB. Cellular Pathology of Parkinson's Disease: Astrocytes, Microglia and Inflammation. Cell Tissue Res. 2004;318(1):149-61. PubMed PMID: 15338271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. AU - Teismann,Peter, AU - Schulz,Jörg B, Y1 - 2004/08/24/ PY - 2004/04/06/received PY - 2004/06/22/accepted PY - 2004/9/1/pubmed PY - 2005/3/5/medline PY - 2004/9/1/entrez SP - 149 EP - 61 JF - Cell and tissue research JO - Cell Tissue Res VL - 318 IS - 1 N2 - Parkinson's disease (PD) is a frequent neurological disorder of the basal ganglia, which is characterized by the progressive loss of dopaminergic neurons mainly in the substantia nigra pars compacta (SNpc). Inflammatory processes have been shown to be associated with the pathogenesis of PD. Activated microglia, as well as to a lesser extent reactive astrocytes, are found in the area associated with cell loss, possibly contributing to the inflammatory process by the release of pro-inflammatory prostaglandins or cytokines. Further deleterious factors released by activated microglia or astrocytes are reactive oxygen species. On the other hand, they may mediate neuroprotective properties by the release of trophic factors or the uptake of glutamate. In this review, we will discuss the different aspects of activated glial cells and potential mechanisms that mediate or protect against cell loss in PD. SN - 0302-766X UR - https://www.unboundmedicine.com/medline/citation/15338271/Cellular_pathology_of_Parkinson's_disease:_astrocytes_microglia_and_inflammation_ DB - PRIME DP - Unbound Medicine ER -
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