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The influence of zinc in mice on infection with Angiostrongylus cantonensis.
Parasitol Res. 2004 Sep; 94(1):74-81.PR

Abstract

BALB/cByJ mice were divided into zinc-deficient (ZD), high zinc-supplemented (ZH), adequately zinc-replete (ZA) and normal control groups by daily dietary control. The body weight in ZD and ZH mice became significantly less than that of normal control mice from 4 weeks (P < 0.002) until 7 weeks (P < 0.0001) after consecutive zinc control. The kinetics of change in body weight of ZD and ZH mice after infection with Angiostrongylus cantonensis were similar to that of uninfected groups mentioned above. The worms recovered at days 7, 14 and 21 after infection from ZD and ZH mice were significantly more in number than that in control mice (P < 0.01). However, the worms from day 21 after infection were shorter in size than those in control mice (P < 0.01). The production of interleukin (IL)-5 was significantly depressed in cultured spleen cells from uninfected and infected ZD and ZH mice, compared with that from respective control group (P < or = 0.02). Furthermore, significantly lower eosinophil counts were observed in the cerebral spinal fluid(CSF) of ZD and ZH mice 3 weeks after infection than in the CSF of control mice (P < 0.001). The levels of immunoglobulins IgG, IgM, IgA and IgE in the supernatant of cultivated spleen cells and serum from ZD and ZH mice were all lower than those of control mice. Thus, the level of zinc correlated with the defence against infection by A. cantonensis, due to the influence of zinc on the growth of mice and their production of IL-5, eosinophils and immunoglobulins.

Authors+Show Affiliations

Mei Ho Institute of Technology, Pingtung, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15338294

Citation

Chen, Chun-Hsiang, et al. "The Influence of Zinc in Mice On Infection With Angiostrongylus Cantonensis." Parasitology Research, vol. 94, no. 1, 2004, pp. 74-81.
Chen CH, Huang YL, Yen CM. The influence of zinc in mice on infection with Angiostrongylus cantonensis. Parasitol Res. 2004;94(1):74-81.
Chen, C. H., Huang, Y. L., & Yen, C. M. (2004). The influence of zinc in mice on infection with Angiostrongylus cantonensis. Parasitology Research, 94(1), 74-81.
Chen CH, Huang YL, Yen CM. The Influence of Zinc in Mice On Infection With Angiostrongylus Cantonensis. Parasitol Res. 2004;94(1):74-81. PubMed PMID: 15338294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of zinc in mice on infection with Angiostrongylus cantonensis. AU - Chen,Chun-Hsiang, AU - Huang,Yeou-Lih, AU - Yen,Chuan-Min, Y1 - 2004/07/31/ PY - 2004/06/14/received PY - 2004/06/25/accepted PY - 2004/9/1/pubmed PY - 2004/12/16/medline PY - 2004/9/1/entrez SP - 74 EP - 81 JF - Parasitology research JO - Parasitol Res VL - 94 IS - 1 N2 - BALB/cByJ mice were divided into zinc-deficient (ZD), high zinc-supplemented (ZH), adequately zinc-replete (ZA) and normal control groups by daily dietary control. The body weight in ZD and ZH mice became significantly less than that of normal control mice from 4 weeks (P < 0.002) until 7 weeks (P < 0.0001) after consecutive zinc control. The kinetics of change in body weight of ZD and ZH mice after infection with Angiostrongylus cantonensis were similar to that of uninfected groups mentioned above. The worms recovered at days 7, 14 and 21 after infection from ZD and ZH mice were significantly more in number than that in control mice (P < 0.01). However, the worms from day 21 after infection were shorter in size than those in control mice (P < 0.01). The production of interleukin (IL)-5 was significantly depressed in cultured spleen cells from uninfected and infected ZD and ZH mice, compared with that from respective control group (P < or = 0.02). Furthermore, significantly lower eosinophil counts were observed in the cerebral spinal fluid(CSF) of ZD and ZH mice 3 weeks after infection than in the CSF of control mice (P < 0.001). The levels of immunoglobulins IgG, IgM, IgA and IgE in the supernatant of cultivated spleen cells and serum from ZD and ZH mice were all lower than those of control mice. Thus, the level of zinc correlated with the defence against infection by A. cantonensis, due to the influence of zinc on the growth of mice and their production of IL-5, eosinophils and immunoglobulins. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/15338294/The_influence_of_zinc_in_mice_on_infection_with_Angiostrongylus_cantonensis_ L2 - https://dx.doi.org/10.1007/s00436-004-1176-7 DB - PRIME DP - Unbound Medicine ER -