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Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-Brazilians.
J Gastroenterol. 2004 Aug; 39(8):717-23.JG

Abstract

BACKGROUND

Secretor (Se) and Lewis (Le) genes are involved in the synthesis of Lewis b (Le(b)) and type I antigens throughout the body, especially in the epithelial cells of gastric mucosa. Helicobacter pylori can attach to the gastric epithelial cells with the blood group antigen-binding adhesin, which binds to Le(b) or H type I carbohydrate structures. In a previous study, a marked association between H. pylori seropositivity and polymorphism of the Se and Le genes was observed among Japanese outpatients of a gastroenterology clinic. The present work aims to investigate the associations between Se and Le gene polymorphisms and H. pylori infection among Japanese-Brazilians.

METHODS

The subjects consisted of 942 healthy volunteer Japanese-Brazilians, who were tested for the presence of anti- H. pylori IgG antibodies and genotyped for Se and Le polymorphisms.

RESULTS

The sex-age-adjusted odds ratios (aORs) for H. pylori seropositivity were 0.99 for the Sese genotype relative to the SeSe genotype (95% confidence interval [CI], 0.73-1.33), and 1.03 for sese relative to SeSe (95% CI, 0.71-1.48). On the other hand, the aOR for the subjects with the le allele (Lele or lele) relative to the LeLe genotype was 1.48 (95% CI, 1.07-1.79). When the Se and Le genotypes were analyzed in combination according to risk group, no statistically significant association was observed.

CONCLUSIONS

These results are inconsistent with previous work and may have been modulated by an external factor or some other unidentified factor. Japanese-Brazilians are genotypically the same as Japanese, but their lifestyle is adapted to that of Brazil. Further investigations are necessary to clarify this influence on susceptibility to H. pylori infection.

Authors+Show Affiliations

Department of Neurology, School of Medicine, University of São Paulo, Av. Dr Arnaldo, 455, 4th Floor, Room 4110, Cerqueira Cesar, 01246-903, São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15338364

Citation

Oba-Shinjo, Sueli Mieko, et al. "Association of Lewis and Secretor Gene Polymorphisms and Helicobacter Pylori Seropositivity Among Japanese-Brazilians." Journal of Gastroenterology, vol. 39, no. 8, 2004, pp. 717-23.
Oba-Shinjo SM, Uno M, Ito LS, et al. Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-Brazilians. J Gastroenterol. 2004;39(8):717-23.
Oba-Shinjo, S. M., Uno, M., Ito, L. S., Shinjo, S. K., Marie, S. K., & Hamajima, N. (2004). Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-Brazilians. Journal of Gastroenterology, 39(8), 717-23.
Oba-Shinjo SM, et al. Association of Lewis and Secretor Gene Polymorphisms and Helicobacter Pylori Seropositivity Among Japanese-Brazilians. J Gastroenterol. 2004;39(8):717-23. PubMed PMID: 15338364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-Brazilians. AU - Oba-Shinjo,Sueli Mieko, AU - Uno,Miyuki, AU - Ito,Lucy Sayuri, AU - Shinjo,Samuel Katsuyuki, AU - Marie,Suely Kazue Nagahashi, AU - Hamajima,Nobuyuki, PY - 2003/09/16/received PY - 2004/02/13/accepted PY - 2004/9/1/pubmed PY - 2005/1/29/medline PY - 2004/9/1/entrez SP - 717 EP - 23 JF - Journal of gastroenterology JO - J Gastroenterol VL - 39 IS - 8 N2 - BACKGROUND: Secretor (Se) and Lewis (Le) genes are involved in the synthesis of Lewis b (Le(b)) and type I antigens throughout the body, especially in the epithelial cells of gastric mucosa. Helicobacter pylori can attach to the gastric epithelial cells with the blood group antigen-binding adhesin, which binds to Le(b) or H type I carbohydrate structures. In a previous study, a marked association between H. pylori seropositivity and polymorphism of the Se and Le genes was observed among Japanese outpatients of a gastroenterology clinic. The present work aims to investigate the associations between Se and Le gene polymorphisms and H. pylori infection among Japanese-Brazilians. METHODS: The subjects consisted of 942 healthy volunteer Japanese-Brazilians, who were tested for the presence of anti- H. pylori IgG antibodies and genotyped for Se and Le polymorphisms. RESULTS: The sex-age-adjusted odds ratios (aORs) for H. pylori seropositivity were 0.99 for the Sese genotype relative to the SeSe genotype (95% confidence interval [CI], 0.73-1.33), and 1.03 for sese relative to SeSe (95% CI, 0.71-1.48). On the other hand, the aOR for the subjects with the le allele (Lele or lele) relative to the LeLe genotype was 1.48 (95% CI, 1.07-1.79). When the Se and Le genotypes were analyzed in combination according to risk group, no statistically significant association was observed. CONCLUSIONS: These results are inconsistent with previous work and may have been modulated by an external factor or some other unidentified factor. Japanese-Brazilians are genotypically the same as Japanese, but their lifestyle is adapted to that of Brazil. Further investigations are necessary to clarify this influence on susceptibility to H. pylori infection. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/15338364/Association_of_Lewis_and_Secretor_gene_polymorphisms_and_Helicobacter_pylori_seropositivity_among_Japanese_Brazilians_ L2 - https://dx.doi.org/10.1007/s00535-004-1384-z DB - PRIME DP - Unbound Medicine ER -