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The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease.
J Gastroenterol 2004; 39(8):734-8JG

Abstract

BACKGROUND

Although Helicobacter pylori infection is typically acquired in childhood, the role of H. pylori infection in gastroduodenal diseases in childhood remains to be defined. The purpose of this study was to evaluate the prevalence of H. pylori infection in children with gastritis, duodenal ulcer, and gastric ulcer.

METHODS

This was a retrospective analysis of 283 Japanese children (mean age, 11.5 years) with non-nodular gastritis (n = 73), nodular gastritis (n = 67), duodenal ulcer (n = 100), and gastric ulcer (n = 43). H. pylori status was based on biopsy tests. Clinical symptoms at the time of endoscopy were analyzed with regard to a possible association with the infection.

RESULTS

The prevalence of H. pylori in non-nodular gastritis, nodular gastritis, duodenal ulcer, and gastric ulcer was 28.8%, 98.5%, 83.0%, and 44.2%, respectively. H. pylori was significantly linked to duodenal ulcer and gastric ulcers in the age group of 10-16 years, but not in the age group of 9 years and under. In children with H. pylori infection, nodular gastritis was observed in 26.3% of gastric ulcer patients and in 74.7% of duodenal ulcer patients (P < 0.001). H. pylori infection was significantly associated with the prevalence of anemia (P < 0.05).

CONCLUSIONS

H. pylori is the most important causal factor for the development of duodenal ulcer in childhood. While H. pylori infection appears to be a risk factor in gastric ulcer, other causes are responsible for most cases. Nodular gastritis is the most common type of H. pylori gastritis in childhood. Chronic infection with H. pylori is associated with anemia.

Authors+Show Affiliations

Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15338366

Citation

Kato, Seiichi, et al. "The Prevalence of Helicobacter Pylori in Japanese Children With Gastritis or Peptic Ulcer Disease." Journal of Gastroenterology, vol. 39, no. 8, 2004, pp. 734-8.
Kato S, Nishino Y, Ozawa K, et al. The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease. J Gastroenterol. 2004;39(8):734-8.
Kato, S., Nishino, Y., Ozawa, K., Konno, M., Maisawa, S., Toyoda, S., ... Iinuma, K. (2004). The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease. Journal of Gastroenterology, 39(8), pp. 734-8.
Kato S, et al. The Prevalence of Helicobacter Pylori in Japanese Children With Gastritis or Peptic Ulcer Disease. J Gastroenterol. 2004;39(8):734-8. PubMed PMID: 15338366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of Helicobacter pylori in Japanese children with gastritis or peptic ulcer disease. AU - Kato,Seiichi, AU - Nishino,Yoshikazu, AU - Ozawa,Kyoko, AU - Konno,Mutsuko, AU - Maisawa,Shun-Ichi, AU - Toyoda,Shigeru, AU - Tajiri,Hitoshi, AU - Ida,Shinobu, AU - Fujisawa,Takuji, AU - Iinuma,Kazuie, PY - 2003/08/29/received PY - 2004/02/13/accepted PY - 2004/9/1/pubmed PY - 2005/1/29/medline PY - 2004/9/1/entrez SP - 734 EP - 8 JF - Journal of gastroenterology JO - J. Gastroenterol. VL - 39 IS - 8 N2 - BACKGROUND: Although Helicobacter pylori infection is typically acquired in childhood, the role of H. pylori infection in gastroduodenal diseases in childhood remains to be defined. The purpose of this study was to evaluate the prevalence of H. pylori infection in children with gastritis, duodenal ulcer, and gastric ulcer. METHODS: This was a retrospective analysis of 283 Japanese children (mean age, 11.5 years) with non-nodular gastritis (n = 73), nodular gastritis (n = 67), duodenal ulcer (n = 100), and gastric ulcer (n = 43). H. pylori status was based on biopsy tests. Clinical symptoms at the time of endoscopy were analyzed with regard to a possible association with the infection. RESULTS: The prevalence of H. pylori in non-nodular gastritis, nodular gastritis, duodenal ulcer, and gastric ulcer was 28.8%, 98.5%, 83.0%, and 44.2%, respectively. H. pylori was significantly linked to duodenal ulcer and gastric ulcers in the age group of 10-16 years, but not in the age group of 9 years and under. In children with H. pylori infection, nodular gastritis was observed in 26.3% of gastric ulcer patients and in 74.7% of duodenal ulcer patients (P < 0.001). H. pylori infection was significantly associated with the prevalence of anemia (P < 0.05). CONCLUSIONS: H. pylori is the most important causal factor for the development of duodenal ulcer in childhood. While H. pylori infection appears to be a risk factor in gastric ulcer, other causes are responsible for most cases. Nodular gastritis is the most common type of H. pylori gastritis in childhood. Chronic infection with H. pylori is associated with anemia. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/15338366/The_prevalence_of_Helicobacter_pylori_in_Japanese_children_with_gastritis_or_peptic_ulcer_disease_ L2 - https://dx.doi.org/10.1007/s00535-004-1381-2 DB - PRIME DP - Unbound Medicine ER -