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[The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice].
Yao Xue Xue Bao. 2004 May; 39(5):380-4.YX

Abstract

AIM

To investigate the enhancing effect on insulin absorption through GI tract in mice by using tomato lectin (TL) modified liposomes as the carrier.

METHODS

TL-phosphatidylethanolamine (PE) conjugate (TL-PE) was synthesized by using carbodiimide cross-linking method, then the compound was incorporated into the conventional liposomes of insulin. The agglutination test was performed to examine TL biological activities after synthesis and incorporation. When TL modified liposomes were administrated orally to the normal mice or diabetic mice at insulin dose of 350 u x kg(-1), the hypoglycemic effect was determinated according to the blood glucose level.

RESULTS

The blood glucose levels of the normal mice were reduced by modified liposomes. The glucose levels were (85 +/- 5)% at 4 h, (54 +/- 11)% at 8 h, (57 +/- 6)% at 12 h postdose compared with the glucose levels prior to oral administration respectively. However, the conventional liposomes and saline have no hypoglycemic effect. The blood glucose levels of the diabetic mice were obviously reduced by TL modified liposomes, the glucose levels were (38 +/- 13)% at 4 h, (50 +/- 15)% at 8 h, (50 +/- 16)% at 12 h respectively.

CONCLUSION

TL modified liposomes promote the oral absorption of insulin due to the specific-site combination on GI cell membrane.

Authors+Show Affiliations

China Pharmaceutical University, Nanjing 210009, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15338884

Citation

Zhang, Na, et al. "[The Enhancing Effect of Tomato Lectin Modified Liposomes of Insulin On Oral Absorption in Mice]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 39, no. 5, 2004, pp. 380-4.
Zhang N, Ping QN, Xu WF. [The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice]. Yao Xue Xue Bao. 2004;39(5):380-4.
Zhang, N., Ping, Q. N., & Xu, W. F. (2004). [The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 39(5), 380-4.
Zhang N, Ping QN, Xu WF. [The Enhancing Effect of Tomato Lectin Modified Liposomes of Insulin On Oral Absorption in Mice]. Yao Xue Xue Bao. 2004;39(5):380-4. PubMed PMID: 15338884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice]. AU - Zhang,Na, AU - Ping,Qi-neng, AU - Xu,Wen-fang, PY - 2004/9/2/pubmed PY - 2004/12/16/medline PY - 2004/9/2/entrez SP - 380 EP - 4 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 39 IS - 5 N2 - AIM: To investigate the enhancing effect on insulin absorption through GI tract in mice by using tomato lectin (TL) modified liposomes as the carrier. METHODS: TL-phosphatidylethanolamine (PE) conjugate (TL-PE) was synthesized by using carbodiimide cross-linking method, then the compound was incorporated into the conventional liposomes of insulin. The agglutination test was performed to examine TL biological activities after synthesis and incorporation. When TL modified liposomes were administrated orally to the normal mice or diabetic mice at insulin dose of 350 u x kg(-1), the hypoglycemic effect was determinated according to the blood glucose level. RESULTS: The blood glucose levels of the normal mice were reduced by modified liposomes. The glucose levels were (85 +/- 5)% at 4 h, (54 +/- 11)% at 8 h, (57 +/- 6)% at 12 h postdose compared with the glucose levels prior to oral administration respectively. However, the conventional liposomes and saline have no hypoglycemic effect. The blood glucose levels of the diabetic mice were obviously reduced by TL modified liposomes, the glucose levels were (38 +/- 13)% at 4 h, (50 +/- 15)% at 8 h, (50 +/- 16)% at 12 h respectively. CONCLUSION: TL modified liposomes promote the oral absorption of insulin due to the specific-site combination on GI cell membrane. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/15338884/[The_enhancing_effect_of_tomato_lectin_modified_liposomes_of_insulin_on_oral_absorption_in_mice]_ DB - PRIME DP - Unbound Medicine ER -