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[Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro].
Yao Xue Xue Bao. 2004 May; 39(5):389-91.YX

Abstract

AIM

To elucidate the mechanism and to present suitable models for the release of sodium ferulate (SF) from hydroxypropyl methylcellulose (HPMC) based matrix tablets.

METHODS

The characteristics and mechanisms of drug release were analyzed from the point of thermodynamic, swelling and diffusion effect. Despite the classical equation of Higuchi, the semi-empirical power law and quadratic curve were also adopted to analogize the release of SF from HPMC based tablets in vitro.

RESULTS

The first release stage of SF was mainly controlled by Fick diffusion, and the rest SF released mainly according to case II transport process caused by the swelling effect of HPMC. The decreased Tg of HPMC, resulted from the entered water, enhanced the release of SF. The power law was possible for the first released 60% SF, but unfit for the last 40% SF. The quadratic curve expressed equation can illuminate the release of SF.

CONCLUSION

For the HPMC system, drug release undertakes the Fick diffusion process followed by the extend of polymer chain. The nonlinear quadratic equation might be valuable to explain the entire drug release from HPMC-based delivery system.

Authors+Show Affiliations

Li FQ
Department of Pharmaceutical Sciences, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Hu JH
No affiliation info available

MeSH

Chemistry, PharmaceuticalCoumaric AcidsDelayed-Action PreparationsDiffusionDrug CarriersDrug Delivery SystemsKineticsLactoseMethylcelluloseOxazinesSolubilityTablets

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15338886

Citation

Li, Feng-qian, and Jin-hong Hu. "[Description of the Release of Sodium Ferulate From Hydroxypropyl Methylcellulose Based Matrix Tablets in Vitro]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 39, no. 5, 2004, pp. 389-91.
Li FQ, Hu JH. [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro]. Yao Xue Xue Bao. 2004;39(5):389-91.
Li, F. Q., & Hu, J. H. (2004). [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 39(5), 389-91.
Li FQ, Hu JH. [Description of the Release of Sodium Ferulate From Hydroxypropyl Methylcellulose Based Matrix Tablets in Vitro]. Yao Xue Xue Bao. 2004;39(5):389-91. PubMed PMID: 15338886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro]. AU - Li,Feng-qian, AU - Hu,Jin-hong, PY - 2004/9/2/pubmed PY - 2004/12/16/medline PY - 2004/9/2/entrez SP - 389 EP - 91 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 39 IS - 5 N2 - AIM: To elucidate the mechanism and to present suitable models for the release of sodium ferulate (SF) from hydroxypropyl methylcellulose (HPMC) based matrix tablets. METHODS: The characteristics and mechanisms of drug release were analyzed from the point of thermodynamic, swelling and diffusion effect. Despite the classical equation of Higuchi, the semi-empirical power law and quadratic curve were also adopted to analogize the release of SF from HPMC based tablets in vitro. RESULTS: The first release stage of SF was mainly controlled by Fick diffusion, and the rest SF released mainly according to case II transport process caused by the swelling effect of HPMC. The decreased Tg of HPMC, resulted from the entered water, enhanced the release of SF. The power law was possible for the first released 60% SF, but unfit for the last 40% SF. The quadratic curve expressed equation can illuminate the release of SF. CONCLUSION: For the HPMC system, drug release undertakes the Fick diffusion process followed by the extend of polymer chain. The nonlinear quadratic equation might be valuable to explain the entire drug release from HPMC-based delivery system. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/15338886/[Description_of_the_release_of_sodium_ferulate_from_hydroxypropyl_methylcellulose_based_matrix_tablets_in_vitro]_ DB - PRIME DP - Unbound Medicine ER -