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[Morphological changes following airway remodeling in asthmatic rats].
Zhong Xi Yi Jie He Xue Bao. 2003 May; 1(1):62-5.ZX

Abstract

OBJECTIVE

To explore the establishment of an asthmatic model with airway remodeling in rats by observing the morphological changes of the airway in different stages.

METHODS

Animals were divided into two groups: asthmatic group and control group. The subjects were observed at 5 phases: before activation and 2, 4, 6, 8 weeks after activation. General histological changes were observed using hematoxylin and eosin stained sections. Being standardized by internal perimeter (Pi), the wall thickness (d), internal area (Ai), outer area (Ao) and wall area (WA) of the airway were quantified by computer-assisted image analysis system. And the membrane airways were divided into 3 grades (large, media and small airways) to be analyzed.

RESULTS

The changes of small airway appeared earlier and greater than the others. The changes of media airway appeared later than the small one. The changes of large airway appeared as later as the 4th week after activation. There were no differences before and after activation in control group (P>0.05).

CONCLUSION

(1) Prolonged, repeated and low density Ag activation could establish asthmatic model with airway remodeling. (2) The morphological changes of the airways increased following airway remodeling, and the greatest increase occurred at small airway. (3)The morphological changes in the model rats were similar to that in human beings.

Authors+Show Affiliations

Respiratory Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15339623

Citation

Wang, Li-Xin, and Yin-Gen Wu. "[Morphological Changes Following Airway Remodeling in Asthmatic Rats]." Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, vol. 1, no. 1, 2003, pp. 62-5.
Wang LX, Wu YG. [Morphological changes following airway remodeling in asthmatic rats]. Zhong Xi Yi Jie He Xue Bao. 2003;1(1):62-5.
Wang, L. X., & Wu, Y. G. (2003). [Morphological changes following airway remodeling in asthmatic rats]. Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine, 1(1), 62-5.
Wang LX, Wu YG. [Morphological Changes Following Airway Remodeling in Asthmatic Rats]. Zhong Xi Yi Jie He Xue Bao. 2003;1(1):62-5. PubMed PMID: 15339623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Morphological changes following airway remodeling in asthmatic rats]. AU - Wang,Li-Xin, AU - Wu,Yin-Gen, PY - 2004/9/2/pubmed PY - 2012/4/3/medline PY - 2004/9/2/entrez SP - 62 EP - 5 JF - Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine JO - Zhong Xi Yi Jie He Xue Bao VL - 1 IS - 1 N2 - OBJECTIVE: To explore the establishment of an asthmatic model with airway remodeling in rats by observing the morphological changes of the airway in different stages. METHODS: Animals were divided into two groups: asthmatic group and control group. The subjects were observed at 5 phases: before activation and 2, 4, 6, 8 weeks after activation. General histological changes were observed using hematoxylin and eosin stained sections. Being standardized by internal perimeter (Pi), the wall thickness (d), internal area (Ai), outer area (Ao) and wall area (WA) of the airway were quantified by computer-assisted image analysis system. And the membrane airways were divided into 3 grades (large, media and small airways) to be analyzed. RESULTS: The changes of small airway appeared earlier and greater than the others. The changes of media airway appeared later than the small one. The changes of large airway appeared as later as the 4th week after activation. There were no differences before and after activation in control group (P>0.05). CONCLUSION: (1) Prolonged, repeated and low density Ag activation could establish asthmatic model with airway remodeling. (2) The morphological changes of the airways increased following airway remodeling, and the greatest increase occurred at small airway. (3)The morphological changes in the model rats were similar to that in human beings. SN - 1672-1977 UR - https://www.unboundmedicine.com/medline/citation/15339623/[Morphological_changes_following_airway_remodeling_in_asthmatic_rats]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -
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