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Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients.
Obes Res. 2004 Aug; 12(8):1256-63.OR

Abstract

OBJECTIVE

To analyze the short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients.

RESEARCH METHODS AND PROCEDURES

Five metabolic cardiovascular risk factors (blood glucose, blood pressure, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triglycerides) were determined before and 15.3 +/- 2.1 months after laparoscopic gastric banding in 650 morbidly obese patients. Global cardiovascular risk was calculated according to the Prospective Cardiovascular Münster (PROCAM) scoring system.

RESULTS

Mean weight loss was 22.7 +/- 20.4 kg. Normalization of the metabolic alteration was observed in 67.3% of patients with diabetes, 38.3% of patients with hypercholesterolemia, 72.5% of patients with low HDL-cholesterol, 72.3% of patients with hypertriglyceridemia, and 46.7% of patients with hypertension. PROCAM score fell from 31.4 +/- 11.6 to 28.0 +/- 12.0 points (p < 0.001). The modifications of total cholesterol and blood pressure were unrelated to percentage weight loss. Percentage weight loss was significantly related to the reductions of fasting blood glucose, triglyceride level, and the PROCAM score and to the increase of HDL-cholesterol concentrations observed after surgery. However, the strength of these four relationships was generally low. The variations of HDL-cholesterol concentrations and blood pressure levels were more influenced by actual energy balance than by the extent of weight loss.

DISCUSSION

Weight loss observed in the first 12 to 18 months after gastric banding was associated with a significant improvement of single cardiovascular risk factors and global risk. On the other hand, the extent of weight loss was poorly related to the magnitude of improvement in cardiovascular risk.

Authors+Show Affiliations

Obesity Unit, Department of Medical and Surgical Sciences, Unviersity of Padova, Padova, Italy. luca.busetto@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15340108

Citation

Busetto, Luca, et al. "Short-term Effects of Weight Loss On the Cardiovascular Risk Factors in Morbidly Obese Patients." Obesity Research, vol. 12, no. 8, 2004, pp. 1256-63.
Busetto L, Sergi G, Enzi G, et al. Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. Obes Res. 2004;12(8):1256-63.
Busetto, L., Sergi, G., Enzi, G., Segato, G., De Marchi, F., Foletto, M., De Luca, M., Pigozzo, S., & Favretti, F. (2004). Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. Obesity Research, 12(8), 1256-63.
Busetto L, et al. Short-term Effects of Weight Loss On the Cardiovascular Risk Factors in Morbidly Obese Patients. Obes Res. 2004;12(8):1256-63. PubMed PMID: 15340108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. AU - Busetto,Luca, AU - Sergi,Giuseppe, AU - Enzi,Giuliano, AU - Segato,Gianni, AU - De Marchi,Francesco, AU - Foletto,Mirto, AU - De Luca,Maurizio, AU - Pigozzo,Sabrina, AU - Favretti,Franco, PY - 2004/9/2/pubmed PY - 2004/10/29/medline PY - 2004/9/2/entrez SP - 1256 EP - 63 JF - Obesity research JO - Obes Res VL - 12 IS - 8 N2 - OBJECTIVE: To analyze the short-term effects of weight loss on the cardiovascular risk factors in morbidly obese patients. RESEARCH METHODS AND PROCEDURES: Five metabolic cardiovascular risk factors (blood glucose, blood pressure, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triglycerides) were determined before and 15.3 +/- 2.1 months after laparoscopic gastric banding in 650 morbidly obese patients. Global cardiovascular risk was calculated according to the Prospective Cardiovascular Münster (PROCAM) scoring system. RESULTS: Mean weight loss was 22.7 +/- 20.4 kg. Normalization of the metabolic alteration was observed in 67.3% of patients with diabetes, 38.3% of patients with hypercholesterolemia, 72.5% of patients with low HDL-cholesterol, 72.3% of patients with hypertriglyceridemia, and 46.7% of patients with hypertension. PROCAM score fell from 31.4 +/- 11.6 to 28.0 +/- 12.0 points (p < 0.001). The modifications of total cholesterol and blood pressure were unrelated to percentage weight loss. Percentage weight loss was significantly related to the reductions of fasting blood glucose, triglyceride level, and the PROCAM score and to the increase of HDL-cholesterol concentrations observed after surgery. However, the strength of these four relationships was generally low. The variations of HDL-cholesterol concentrations and blood pressure levels were more influenced by actual energy balance than by the extent of weight loss. DISCUSSION: Weight loss observed in the first 12 to 18 months after gastric banding was associated with a significant improvement of single cardiovascular risk factors and global risk. On the other hand, the extent of weight loss was poorly related to the magnitude of improvement in cardiovascular risk. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15340108/Short_term_effects_of_weight_loss_on_the_cardiovascular_risk_factors_in_morbidly_obese_patients_ DB - PRIME DP - Unbound Medicine ER -