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Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans.
Obes Res. 2004 Aug; 12(8):1352-9.OR

Abstract

OBJECTIVE

The contribution of visceral adipose tissue (VAT) to insulin resistance is well-established; however, the role of subcutaneous abdominal adipose tissue (SAT) in insulin resistance remains controversial. Sex may determine which of these two components of abdominal obesity is more strongly related to insulin resistance and its consequences. The aim of this study was to determine whether both VAT and SAT contribute to insulin resistance in African Americans and to examine the effects of sex on this relationship.

RESEARCH METHODS AND PROCEDURES

This was a cross-sectional study of 78 nondiabetic African-American volunteers (44 men, 35 women; age 33.8 +/- 7.3 years; BMI 30.9 +/- 7.4 kg/m2). VAT and SAT volumes were measured using serial computerized tomography slices from the dome of the diaphragm to the iliac crest. The insulin sensitivity index (SI) was determined from the minimal model using data obtained from the frequently sampled intravenous glucose tolerance test.

RESULTS

In men, both VAT and SAT were negatively correlated with SI (r for both correlations = -0.57; p < 0.01). In women, the correlation coefficient between VAT and SI was -0.50 (p < 0.01) and between SAT and SI was -0.67 (p < 0.01). In women, the correlation coefficient for SI with SAT was significantly greater than the correlation coefficient with VAT (p = 0.02).

DISCUSSION

Both SAT and VAT are strongly correlated with insulin resistance in African Americans. For African-American women, SAT may have a greater effect than VAT on insulin resistance.

Authors+Show Affiliations

Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, Pheonix, AZ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15340119

Citation

Tulloch-Reid, Marshall K., et al. "Both Subcutaneous and Visceral Adipose Tissue Correlate Highly With Insulin Resistance in African Americans." Obesity Research, vol. 12, no. 8, 2004, pp. 1352-9.
Tulloch-Reid MK, Hanson RL, Sebring NG, et al. Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans. Obes Res. 2004;12(8):1352-9.
Tulloch-Reid, M. K., Hanson, R. L., Sebring, N. G., Reynolds, J. C., Premkumar, A., Genovese, D. J., & Sumner, A. E. (2004). Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans. Obesity Research, 12(8), 1352-9.
Tulloch-Reid MK, et al. Both Subcutaneous and Visceral Adipose Tissue Correlate Highly With Insulin Resistance in African Americans. Obes Res. 2004;12(8):1352-9. PubMed PMID: 15340119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Both subcutaneous and visceral adipose tissue correlate highly with insulin resistance in african americans. AU - Tulloch-Reid,Marshall K, AU - Hanson,Robert L, AU - Sebring,Nancy G, AU - Reynolds,James C, AU - Premkumar,Ahalya, AU - Genovese,David J, AU - Sumner,Anne E, PY - 2004/9/2/pubmed PY - 2004/10/29/medline PY - 2004/9/2/entrez SP - 1352 EP - 9 JF - Obesity research JO - Obes Res VL - 12 IS - 8 N2 - OBJECTIVE: The contribution of visceral adipose tissue (VAT) to insulin resistance is well-established; however, the role of subcutaneous abdominal adipose tissue (SAT) in insulin resistance remains controversial. Sex may determine which of these two components of abdominal obesity is more strongly related to insulin resistance and its consequences. The aim of this study was to determine whether both VAT and SAT contribute to insulin resistance in African Americans and to examine the effects of sex on this relationship. RESEARCH METHODS AND PROCEDURES: This was a cross-sectional study of 78 nondiabetic African-American volunteers (44 men, 35 women; age 33.8 +/- 7.3 years; BMI 30.9 +/- 7.4 kg/m2). VAT and SAT volumes were measured using serial computerized tomography slices from the dome of the diaphragm to the iliac crest. The insulin sensitivity index (SI) was determined from the minimal model using data obtained from the frequently sampled intravenous glucose tolerance test. RESULTS: In men, both VAT and SAT were negatively correlated with SI (r for both correlations = -0.57; p < 0.01). In women, the correlation coefficient between VAT and SI was -0.50 (p < 0.01) and between SAT and SI was -0.67 (p < 0.01). In women, the correlation coefficient for SI with SAT was significantly greater than the correlation coefficient with VAT (p = 0.02). DISCUSSION: Both SAT and VAT are strongly correlated with insulin resistance in African Americans. For African-American women, SAT may have a greater effect than VAT on insulin resistance. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15340119/Both_subcutaneous_and_visceral_adipose_tissue_correlate_highly_with_insulin_resistance_in_african_americans_ L2 - https://doi.org/10.1038/oby.2004.170 DB - PRIME DP - Unbound Medicine ER -