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Discovery of new orally active phosphodiesterase (PDE4) inhibitors.
Chem Pharm Bull (Tokyo) 2004; 52(9):1098-104CP

Abstract

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.

Authors+Show Affiliations

Minase Research Institute, Ono Pharmaceutical Co., Ltd., Mishima, Osaka 618-8585, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15340197

Citation

Ochiai, Hiroshi, et al. "Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors." Chemical & Pharmaceutical Bulletin, vol. 52, no. 9, 2004, pp. 1098-104.
Ochiai H, Ishida A, Ohtani T, et al. Discovery of new orally active phosphodiesterase (PDE4) inhibitors. Chem Pharm Bull. 2004;52(9):1098-104.
Ochiai, H., Ishida, A., Ohtani, T., Kusumi, K., Kishikawa, K., Yamamoto, S., ... Toda, M. (2004). Discovery of new orally active phosphodiesterase (PDE4) inhibitors. Chemical & Pharmaceutical Bulletin, 52(9), pp. 1098-104.
Ochiai H, et al. Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors. Chem Pharm Bull. 2004;52(9):1098-104. PubMed PMID: 15340197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discovery of new orally active phosphodiesterase (PDE4) inhibitors. AU - Ochiai,Hiroshi, AU - Ishida,Akiharu, AU - Ohtani,Tazumi, AU - Kusumi,Kensuke, AU - Kishikawa,Katuya, AU - Yamamoto,Susumu, AU - Takeda,Hiroshi, AU - Obata,Takaaki, AU - Nakai,Hisao, AU - Toda,Masaaki, PY - 2004/9/2/pubmed PY - 2005/2/24/medline PY - 2004/9/2/entrez SP - 1098 EP - 104 JF - Chemical & pharmaceutical bulletin JO - Chem. Pharm. Bull. VL - 52 IS - 9 N2 - A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented. SN - 0009-2363 UR - https://www.unboundmedicine.com/medline/citation/15340197/Discovery_of_new_orally_active_phosphodiesterase__PDE4__inhibitors_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/52.1098?from=PubMed DB - PRIME DP - Unbound Medicine ER -