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The endocannabinoid system and its therapeutic exploitation.
Nat Rev Drug Discov 2004; 3(9):771-84NR

Abstract

The term 'endocannabinoid' - originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands - now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come.

Authors+Show Affiliations

Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Napoli, Italy. vdimarzo@icmib.na.cnr.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15340387

Citation

Di Marzo, Vincenzo, et al. "The Endocannabinoid System and Its Therapeutic Exploitation." Nature Reviews. Drug Discovery, vol. 3, no. 9, 2004, pp. 771-84.
Di Marzo V, Bifulco M, De Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov. 2004;3(9):771-84.
Di Marzo, V., Bifulco, M., & De Petrocellis, L. (2004). The endocannabinoid system and its therapeutic exploitation. Nature Reviews. Drug Discovery, 3(9), pp. 771-84.
Di Marzo V, Bifulco M, De Petrocellis L. The Endocannabinoid System and Its Therapeutic Exploitation. Nat Rev Drug Discov. 2004;3(9):771-84. PubMed PMID: 15340387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The endocannabinoid system and its therapeutic exploitation. AU - Di Marzo,Vincenzo, AU - Bifulco,Maurizio, AU - De Petrocellis,Luciano, PY - 2004/9/2/pubmed PY - 2004/10/1/medline PY - 2004/9/2/entrez SP - 771 EP - 84 JF - Nature reviews. Drug discovery JO - Nat Rev Drug Discov VL - 3 IS - 9 N2 - The term 'endocannabinoid' - originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands - now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come. SN - 1474-1776 UR - https://www.unboundmedicine.com/medline/citation/15340387/The_endocannabinoid_system_and_its_therapeutic_exploitation_ L2 - http://dx.doi.org/10.1038/nrd1495 DB - PRIME DP - Unbound Medicine ER -