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Intranasal irradiation with the xenon chloride ultraviolet B laser improves allergic rhinitis.
J Photochem Photobiol B. 2004 Sep 08; 75(3):137-44.JP

Abstract

We earlier reported that the 308 nm xenon chloride (XeCl) ultraviolet B (UVB) laser is highly effective for the treatment of inflammatory skin diseases. Since UVB irradiation has been shown to exert both local and systemic immunosuppression, we investigated the clinical efficacy of UVB irradiation in allergic rhinitis. In an open study, groups of patients with severe allergic rhinitis received intranasal irradiation with a 308 nm XeCl UVB excimer laser for two weeks. In the low-dose group (n=10), treatment was given twice weekly, starting with 0.25x the individual minimal erythema dose (MED), whereas patients in the medium-dose group (n=8) were treated four times weekly, starting with 0.4x MED. In each group, the dosage was gradually increased. Evaluation was based on the symptom scores. The effect of the XeCl laser on the skin prick test reaction was also studied. In the low-dose group, seven patients completed the study, and there was no improvement in the nasal symptoms. In the medium-dose group, the XeCl UVB irradiation significantly inhibited the rhinorrhoea, the sneezing, the nasal obstruction and the total nasal score (p<0.05). The XeCl UVB excimer laser also inhibited the allergen-induced skin prick test in a dose-dependent manner. These results suggest that the XeCl UVB excimer laser might serve as a new therapeutic tool in the treatment of allergic rhinitis.

Authors+Show Affiliations

Department of Dermatology and Allergology, University of Szeged, P.O. Box 427, H-6701 Szeged, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15341927

Citation

Csoma, Zsanett, et al. "Intranasal Irradiation With the Xenon Chloride Ultraviolet B Laser Improves Allergic Rhinitis." Journal of Photochemistry and Photobiology. B, Biology, vol. 75, no. 3, 2004, pp. 137-44.
Csoma Z, Ignacz F, Bor Z, et al. Intranasal irradiation with the xenon chloride ultraviolet B laser improves allergic rhinitis. J Photochem Photobiol B, Biol. 2004;75(3):137-44.
Csoma, Z., Ignacz, F., Bor, Z., Szabo, G., Bodai, L., Dobozy, A., & Kemeny, L. (2004). Intranasal irradiation with the xenon chloride ultraviolet B laser improves allergic rhinitis. Journal of Photochemistry and Photobiology. B, Biology, 75(3), 137-44.
Csoma Z, et al. Intranasal Irradiation With the Xenon Chloride Ultraviolet B Laser Improves Allergic Rhinitis. J Photochem Photobiol B, Biol. 2004 Sep 8;75(3):137-44. PubMed PMID: 15341927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intranasal irradiation with the xenon chloride ultraviolet B laser improves allergic rhinitis. AU - Csoma,Zsanett, AU - Ignacz,Ferenc, AU - Bor,Zsolt, AU - Szabo,Gabor, AU - Bodai,Laszlo, AU - Dobozy,Attila, AU - Kemeny,Lajos, PY - 2004/01/09/received PY - 2004/04/23/revised PY - 2004/05/04/accepted PY - 2004/9/3/pubmed PY - 2005/2/11/medline PY - 2004/9/3/entrez SP - 137 EP - 44 JF - Journal of photochemistry and photobiology. B, Biology JO - J. Photochem. Photobiol. B, Biol. VL - 75 IS - 3 N2 - We earlier reported that the 308 nm xenon chloride (XeCl) ultraviolet B (UVB) laser is highly effective for the treatment of inflammatory skin diseases. Since UVB irradiation has been shown to exert both local and systemic immunosuppression, we investigated the clinical efficacy of UVB irradiation in allergic rhinitis. In an open study, groups of patients with severe allergic rhinitis received intranasal irradiation with a 308 nm XeCl UVB excimer laser for two weeks. In the low-dose group (n=10), treatment was given twice weekly, starting with 0.25x the individual minimal erythema dose (MED), whereas patients in the medium-dose group (n=8) were treated four times weekly, starting with 0.4x MED. In each group, the dosage was gradually increased. Evaluation was based on the symptom scores. The effect of the XeCl laser on the skin prick test reaction was also studied. In the low-dose group, seven patients completed the study, and there was no improvement in the nasal symptoms. In the medium-dose group, the XeCl UVB irradiation significantly inhibited the rhinorrhoea, the sneezing, the nasal obstruction and the total nasal score (p<0.05). The XeCl UVB excimer laser also inhibited the allergen-induced skin prick test in a dose-dependent manner. These results suggest that the XeCl UVB excimer laser might serve as a new therapeutic tool in the treatment of allergic rhinitis. SN - 1011-1344 UR - https://www.unboundmedicine.com/medline/citation/15341927/Intranasal_irradiation_with_the_xenon_chloride_ultraviolet_B_laser_improves_allergic_rhinitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1011134404000624 DB - PRIME DP - Unbound Medicine ER -