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Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction.
J Cataract Refract Surg. 2004 Sep; 30(9):1875-82.JC

Abstract

PURPOSE

To examine the influence of intraocular lens (IOL) optic edge design and optic material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction.

SETTING

Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

METHODS

This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex OptiEdge silicone IOL with a sharp posterior optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm(2)) was determined objectively.

RESULTS

One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P<.05). In the silicone group, the mean was 31% and 26%, respectively (P<.05). The mean fibrotic PCO score was lower in eyes with a sharp-edged acrylic IOL than in eyes with a round-edged acrylic IOL (0.26 and 0.93, respectively; P<.05) and in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (0.24 and 0.82, respectively; P<.001). At 1 year, the mean capsulorhexis area was statistically significantly smaller in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (P<.05).

CONCLUSIONS

Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.

Authors+Show Affiliations

Sacu S
Department of Ophthalmology, Medical University of Vienna, A-1090 Vienna, Austria. rupert.menapace@univie.ac.at
Menapace R
No affiliation info available
Buehl W
No affiliation info available
Rainer G
No affiliation info available
Findl O
No affiliation info available

MeSH

Acrylic ResinsAgedBiocompatible MaterialsCapsulorhexisCataractContractureDouble-Blind MethodFibrosisHumansLens Capsule, CrystallineLens Implantation, IntraocularLenses, IntraocularPhacoemulsificationPostoperative ComplicationsProspective StudiesProsthesis DesignSilicone Elastomers

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15342049

Citation

Sacu, Stefan, et al. "Effect of Intraocular Lens Optic Edge Design and Material On Fibrotic Capsule Opacification and Capsulorhexis Contraction." Journal of Cataract and Refractive Surgery, vol. 30, no. 9, 2004, pp. 1875-82.
Sacu S, Menapace R, Buehl W, et al. Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction. J Cataract Refract Surg. 2004;30(9):1875-82.
Sacu, S., Menapace, R., Buehl, W., Rainer, G., & Findl, O. (2004). Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction. Journal of Cataract and Refractive Surgery, 30(9), 1875-82.
Sacu S, et al. Effect of Intraocular Lens Optic Edge Design and Material On Fibrotic Capsule Opacification and Capsulorhexis Contraction. J Cataract Refract Surg. 2004;30(9):1875-82. PubMed PMID: 15342049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intraocular lens optic edge design and material on fibrotic capsule opacification and capsulorhexis contraction. AU - Sacu,Stefan, AU - Menapace,Rupert, AU - Buehl,Wolf, AU - Rainer,Georg, AU - Findl,Oliver, PY - 2004/01/22/accepted PY - 2004/9/3/pubmed PY - 2004/11/17/medline PY - 2004/9/3/entrez SP - 1875 EP - 82 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 30 IS - 9 N2 - PURPOSE: To examine the influence of intraocular lens (IOL) optic edge design and optic material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. SETTING: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. METHODS: This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex OptiEdge silicone IOL with a sharp posterior optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm(2)) was determined objectively. RESULTS: One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P<.05). In the silicone group, the mean was 31% and 26%, respectively (P<.05). The mean fibrotic PCO score was lower in eyes with a sharp-edged acrylic IOL than in eyes with a round-edged acrylic IOL (0.26 and 0.93, respectively; P<.05) and in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (0.24 and 0.82, respectively; P<.001). At 1 year, the mean capsulorhexis area was statistically significantly smaller in eyes with a sharp-edged silicone IOL than in eyes with a round-edged silicone IOL (P<.05). CONCLUSIONS: Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/15342049/Effect_of_intraocular_lens_optic_edge_design_and_material_on_fibrotic_capsule_opacification_and_capsulorhexis_contraction_ DB - PRIME DP - Unbound Medicine ER -