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Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway.
Cereb Cortex. 2005 May; 15(5):663-9.CC

Abstract

Phencyclidine (PCP) is a psychotomimetic drug that elicits schizophrenia-like symptoms in healthy persons, and administration of PCP to animals is used as a pharmacological model of schizophrenia. We recently demonstrated that systemic administration of PCP to rats produces long-lasting activation of medial prefrontal cortex (mPFC) neurons with augmentation of locomotor activity, whereas direct application of PCP to mPFC neurons has little effect on their firing activity. These findings suggest that PCP-induced activation of mPFC neurons is elicited mainly via excitatory inputs from regions outside the mPFC. In the present study, we examined effects of local application of PCP to the ventral hippocampus (vHIP) on firing activity of PFC neurons in freely moving rats. PCP locally perfused into the vHIP increased spontaneous discharges of PFC neurons during perfusion with augmentation of locomotor activity. Local application of a more selective NMDA receptor antagonist, MK801, to vHIP neurons under anesthesia increased the spontaneous firing rates of most neurons directly projecting to the mPFC, whereas local application of MK801 to mPFC neurons did not induce excitatory responses in any of those neurons. The present results indicate that tonic excitatory inputs from the vHIP to the PFC may trigger development of behavioral abnormalities.

Authors+Show Affiliations

Department of Physiology, Fukushima Medical University School of Medicine, 1 Hikari-ga-oka, Fukushima 960-1295, Japan. jodo1019@fmu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15342431

Citation

Jodo, Eiichi, et al. "Activation of Medial Prefrontal Cortex By Phencyclidine Is Mediated Via a Hippocampo-prefrontal Pathway." Cerebral Cortex (New York, N.Y. : 1991), vol. 15, no. 5, 2005, pp. 663-9.
Jodo E, Suzuki Y, Katayama T, et al. Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway. Cereb Cortex. 2005;15(5):663-9.
Jodo, E., Suzuki, Y., Katayama, T., Hoshino, K. Y., Takeuchi, S., Niwa, S., & Kayama, Y. (2005). Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway. Cerebral Cortex (New York, N.Y. : 1991), 15(5), 663-9.
Jodo E, et al. Activation of Medial Prefrontal Cortex By Phencyclidine Is Mediated Via a Hippocampo-prefrontal Pathway. Cereb Cortex. 2005;15(5):663-9. PubMed PMID: 15342431.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway. AU - Jodo,Eiichi, AU - Suzuki,Yoshiaki, AU - Katayama,Tadahiro, AU - Hoshino,Ken-Yo, AU - Takeuchi,Satoshi, AU - Niwa,Shin-Ichi, AU - Kayama,Yukihiko, Y1 - 2004/09/01/ PY - 2004/9/3/pubmed PY - 2005/6/1/medline PY - 2004/9/3/entrez SP - 663 EP - 9 JF - Cerebral cortex (New York, N.Y. : 1991) JO - Cereb Cortex VL - 15 IS - 5 N2 - Phencyclidine (PCP) is a psychotomimetic drug that elicits schizophrenia-like symptoms in healthy persons, and administration of PCP to animals is used as a pharmacological model of schizophrenia. We recently demonstrated that systemic administration of PCP to rats produces long-lasting activation of medial prefrontal cortex (mPFC) neurons with augmentation of locomotor activity, whereas direct application of PCP to mPFC neurons has little effect on their firing activity. These findings suggest that PCP-induced activation of mPFC neurons is elicited mainly via excitatory inputs from regions outside the mPFC. In the present study, we examined effects of local application of PCP to the ventral hippocampus (vHIP) on firing activity of PFC neurons in freely moving rats. PCP locally perfused into the vHIP increased spontaneous discharges of PFC neurons during perfusion with augmentation of locomotor activity. Local application of a more selective NMDA receptor antagonist, MK801, to vHIP neurons under anesthesia increased the spontaneous firing rates of most neurons directly projecting to the mPFC, whereas local application of MK801 to mPFC neurons did not induce excitatory responses in any of those neurons. The present results indicate that tonic excitatory inputs from the vHIP to the PFC may trigger development of behavioral abnormalities. SN - 1047-3211 UR - https://www.unboundmedicine.com/medline/citation/15342431/Activation_of_medial_prefrontal_cortex_by_phencyclidine_is_mediated_via_a_hippocampo_prefrontal_pathway_ L2 - https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhh168 DB - PRIME DP - Unbound Medicine ER -