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Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status.

Abstract

Whether fruit, vegetable, and antioxidant micronutrient consumption is associated with a reduction in breast cancer incidence remains unresolved. To address this issue, we analyzed data from a large population-based case-control study, with consideration given to whether the associations varied with menopausal status or with clinical characteristics of the cases' disease. Study participants completed a modified Block food frequency questionnaire, which included assessment of the frequency and portion sizes of 13 fruits and fruit juices and 16 vegetables and the use of multiple and single vitamin supplements. Statistical analyses were done on 1,463 cases and 1,500 controls. Among postmenopausal women, reduced odds ratios [OR; 95% confidence intervals (95% CI)] were noted for the highest fifth, as compared with the lowest fifth, of intake of any vegetables [0.63 (0.46-0.86); P for trend < 0.01] and leafy vegetables [0.66 (0.50-0.86); P for trend = 0.03] after controlling for age and energy intake. Adjusted ORs (95% CIs) were also decreased for postmenopausal breast cancer in relation to high intake of carotenoids, alpha-carotene, beta-carotene, lutein, and particularly lycopene [0.66 (0.48-0.90); P for trend = 0.03]. Inverse associations for fruits and vegetables were stronger for postmenopausal women with estrogen receptor (ER)+ tumors (OR, 0.65; 95% CI, 0.51-0.82) than ER- tumors (OR, 0.92; 95% CI, 0.64-1.32), but results were less consistent for micronutrients. No similarly reduced associations were observed among premenopausal women. ORs did not appreciably differ by in situ or invasive breast cancer or by whether cases had begun chemotherapy. Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599-7435, USA. gaudet@email.unc.edu

    , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Antioxidants
    Breast
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Intraductal, Noninfiltrating
    Case-Control Studies
    Feeding Behavior
    Female
    Fruit
    Humans
    Menopause
    Micronutrients
    Middle Aged
    Neoplasms, Hormone-Dependent
    New York
    Nutrition Surveys
    Odds Ratio
    Receptors, Estrogen
    Receptors, Progesterone
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15342450

    Citation

    Gaudet, Mia M., et al. "Fruits, Vegetables, and Micronutrients in Relation to Breast Cancer Modified By Menopause and Hormone Receptor Status." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 13, no. 9, 2004, pp. 1485-94.
    Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1485-94.
    Gaudet, M. M., Britton, J. A., Kabat, G. C., Steck-Scott, S., Eng, S. M., Teitelbaum, S. L., ... Gammon, M. D. (2004). Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 13(9), pp. 1485-94.
    Gaudet MM, et al. Fruits, Vegetables, and Micronutrients in Relation to Breast Cancer Modified By Menopause and Hormone Receptor Status. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1485-94. PubMed PMID: 15342450.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. AU - Gaudet,Mia M, AU - Britton,Julie A, AU - Kabat,Geoffrey C, AU - Steck-Scott,Susan, AU - Eng,Sybil M, AU - Teitelbaum,Susan L, AU - Terry,Mary Beth, AU - Neugut,Alfred I, AU - Gammon,Marilie D, PY - 2004/9/3/pubmed PY - 2005/2/3/medline PY - 2004/9/3/entrez SP - 1485 EP - 94 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 13 IS - 9 N2 - Whether fruit, vegetable, and antioxidant micronutrient consumption is associated with a reduction in breast cancer incidence remains unresolved. To address this issue, we analyzed data from a large population-based case-control study, with consideration given to whether the associations varied with menopausal status or with clinical characteristics of the cases' disease. Study participants completed a modified Block food frequency questionnaire, which included assessment of the frequency and portion sizes of 13 fruits and fruit juices and 16 vegetables and the use of multiple and single vitamin supplements. Statistical analyses were done on 1,463 cases and 1,500 controls. Among postmenopausal women, reduced odds ratios [OR; 95% confidence intervals (95% CI)] were noted for the highest fifth, as compared with the lowest fifth, of intake of any vegetables [0.63 (0.46-0.86); P for trend < 0.01] and leafy vegetables [0.66 (0.50-0.86); P for trend = 0.03] after controlling for age and energy intake. Adjusted ORs (95% CIs) were also decreased for postmenopausal breast cancer in relation to high intake of carotenoids, alpha-carotene, beta-carotene, lutein, and particularly lycopene [0.66 (0.48-0.90); P for trend = 0.03]. Inverse associations for fruits and vegetables were stronger for postmenopausal women with estrogen receptor (ER)+ tumors (OR, 0.65; 95% CI, 0.51-0.82) than ER- tumors (OR, 0.92; 95% CI, 0.64-1.32), but results were less consistent for micronutrients. No similarly reduced associations were observed among premenopausal women. ORs did not appreciably differ by in situ or invasive breast cancer or by whether cases had begun chemotherapy. Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/15342450/Fruits_vegetables_and_micronutrients_in_relation_to_breast_cancer_modified_by_menopause_and_hormone_receptor_status_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=15342450 DB - PRIME DP - Unbound Medicine ER -