Tags

Type your tag names separated by a space and hit enter

A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study.
Arterioscler Thromb 1992; 12(6):701-7AT

Abstract

The incidence of coronary heart disease (CHD) in middle-aged men is more than three times higher in Northern Ireland than in France. The ECTIM study, which is based on WHO MONICA centers in Belfast (Northern Ireland), Strasbourg (eastern France), Toulouse (southwestern France), and Lille (northern France), has been established to investigate this striking difference. Male patients aged 25-64 years with myocardial infarction (MI) and control subjects sampled from the general population were recruited in the four centers. Hypolipidemic drug treatment was much more frequent in France than in Belfast. "Hypercholesterolemia" defined by the presence of hypolipidemic drug treatment or a low density liproprotein cholesterol level greater than 200 mg/dl was more frequent in cases than in controls in both countries but was similar in both control groups. An in-depth study of lipid variables, including measurements of cholesterol fractions, triglycerides, apolipoproteins (apo), and lipoprotein particles (Lp), was performed in nonhypercholesterolemic subjects. In Northern Ireland and France, patients in comparison with controls had lower levels of high density lipoprotein cholesterol, apo A-I, apo A-II, Lp A-I, and Lp A-II:A-I and higher levels of Lp E:B and Lp(a):B. The levels of triglycerides, very low density lipoprotein cholesterol, apo B, and Lp C-III:B were higher in cases than in controls only in Belfast. In control subjects, the mean levels of cholesterol fractions and apolipoproteins were similar in Northern Ireland and France; however, the level of Lp A-I was lower and the levels of Lp E:B and Lp(a):B were higher in Northern Ireland than in France.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

SERLIA, Institut Pasteur, Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1534257

Citation

Parra, H J., et al. "A Case-control Study of Lipoprotein Particles in Two Populations at Contrasting Risk for Coronary Heart Disease. the ECTIM Study." Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, vol. 12, no. 6, 1992, pp. 701-7.
Parra HJ, Arveiler D, Evans AE, et al. A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. Arterioscler Thromb. 1992;12(6):701-7.
Parra, H. J., Arveiler, D., Evans, A. E., Cambou, J. P., Amouyel, P., Bingham, A., ... Luc, G. (1992). A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology, 12(6), pp. 701-7.
Parra HJ, et al. A Case-control Study of Lipoprotein Particles in Two Populations at Contrasting Risk for Coronary Heart Disease. the ECTIM Study. Arterioscler Thromb. 1992;12(6):701-7. PubMed PMID: 1534257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. A1 - Parra,H J, AU - Arveiler,D, AU - Evans,A E, AU - Cambou,J P, AU - Amouyel,P, AU - Bingham,A, AU - McMaster,D, AU - Schaffer,P, AU - Douste-Blazy,P, AU - Luc,G, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 701 EP - 7 JF - Arteriosclerosis and thrombosis : a journal of vascular biology JO - Arterioscler. Thromb. VL - 12 IS - 6 N2 - The incidence of coronary heart disease (CHD) in middle-aged men is more than three times higher in Northern Ireland than in France. The ECTIM study, which is based on WHO MONICA centers in Belfast (Northern Ireland), Strasbourg (eastern France), Toulouse (southwestern France), and Lille (northern France), has been established to investigate this striking difference. Male patients aged 25-64 years with myocardial infarction (MI) and control subjects sampled from the general population were recruited in the four centers. Hypolipidemic drug treatment was much more frequent in France than in Belfast. "Hypercholesterolemia" defined by the presence of hypolipidemic drug treatment or a low density liproprotein cholesterol level greater than 200 mg/dl was more frequent in cases than in controls in both countries but was similar in both control groups. An in-depth study of lipid variables, including measurements of cholesterol fractions, triglycerides, apolipoproteins (apo), and lipoprotein particles (Lp), was performed in nonhypercholesterolemic subjects. In Northern Ireland and France, patients in comparison with controls had lower levels of high density lipoprotein cholesterol, apo A-I, apo A-II, Lp A-I, and Lp A-II:A-I and higher levels of Lp E:B and Lp(a):B. The levels of triglycerides, very low density lipoprotein cholesterol, apo B, and Lp C-III:B were higher in cases than in controls only in Belfast. In control subjects, the mean levels of cholesterol fractions and apolipoproteins were similar in Northern Ireland and France; however, the level of Lp A-I was lower and the levels of Lp E:B and Lp(a):B were higher in Northern Ireland than in France.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1049-8834 UR - https://www.unboundmedicine.com/medline/citation/1534257/A_case_control_study_of_lipoprotein_particles_in_two_populations_at_contrasting_risk_for_coronary_heart_disease__The_ECTIM_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1534257.ui DB - PRIME DP - Unbound Medicine ER -