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Effect of cilazapril on regional left ventricular wall thickness and chamber dimension following acute myocardial infarction: in vivo assessment using MRI.
Am Heart J. 1992 Jun; 123(6):1472-80.AH

Abstract

The primary goal of the current study was to assess in situ, using magnetic resonance imaging, the effect of a new angiotensin-converting enzyme inhibitor, cilazapril, in reducing left ventricular remodeling after acute myocardial infarction. Three groups of animals were investigated: (1) sham-operated rats (n = 19); (2) infarcted rats receiving no treatment (n = 23); and (3) infarcted rats receiving cilazapril (100 mg/L drinking water, n = 20). Treatment with cilazapril began on the third day postocclusion and continued for 3 to 4 months. Myocardial infarction was produced by ligation of the left coronary artery, and electrocardiographic (ECG)-gated short-axis images were acquired 3 to 4 months later. Sham-operated animals were subjected to the same procedure but the left coronary artery was not ligated. From the image acquired in the middle of the left ventricle (equatorial slice), left ventricular wall thicknesses, chamber diameters, and surface area measurements of the cavities were determined. At autopsy examination, infarct size and tissue water content were determined. The results demonstrate that magnetic resonance imaging has the potential to assess in situ the alterations of left ventricular dimensions and mass after acute myocardial infarction and can be used to document the influence of therapeutic interventions. Cilazapril provided protection against the deleterious remodeling changes such as ventricular dilation and wall thinning consequent to acute myocardial infarction.

Authors+Show Affiliations

Department of Radiology, University of California, San Francisco 94143.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1534434

Citation

Saeed, M, et al. "Effect of Cilazapril On Regional Left Ventricular Wall Thickness and Chamber Dimension Following Acute Myocardial Infarction: in Vivo Assessment Using MRI." American Heart Journal, vol. 123, no. 6, 1992, pp. 1472-80.
Saeed M, Wendland MF, Seelos K, et al. Effect of cilazapril on regional left ventricular wall thickness and chamber dimension following acute myocardial infarction: in vivo assessment using MRI. Am Heart J. 1992;123(6):1472-80.
Saeed, M., Wendland, M. F., Seelos, K., Masui, T., Derugin, N., & Higgins, C. B. (1992). Effect of cilazapril on regional left ventricular wall thickness and chamber dimension following acute myocardial infarction: in vivo assessment using MRI. American Heart Journal, 123(6), 1472-80.
Saeed M, et al. Effect of Cilazapril On Regional Left Ventricular Wall Thickness and Chamber Dimension Following Acute Myocardial Infarction: in Vivo Assessment Using MRI. Am Heart J. 1992;123(6):1472-80. PubMed PMID: 1534434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cilazapril on regional left ventricular wall thickness and chamber dimension following acute myocardial infarction: in vivo assessment using MRI. AU - Saeed,M, AU - Wendland,M F, AU - Seelos,K, AU - Masui,T, AU - Derugin,N, AU - Higgins,C B, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 1472 EP - 80 JF - American heart journal JO - Am Heart J VL - 123 IS - 6 N2 - The primary goal of the current study was to assess in situ, using magnetic resonance imaging, the effect of a new angiotensin-converting enzyme inhibitor, cilazapril, in reducing left ventricular remodeling after acute myocardial infarction. Three groups of animals were investigated: (1) sham-operated rats (n = 19); (2) infarcted rats receiving no treatment (n = 23); and (3) infarcted rats receiving cilazapril (100 mg/L drinking water, n = 20). Treatment with cilazapril began on the third day postocclusion and continued for 3 to 4 months. Myocardial infarction was produced by ligation of the left coronary artery, and electrocardiographic (ECG)-gated short-axis images were acquired 3 to 4 months later. Sham-operated animals were subjected to the same procedure but the left coronary artery was not ligated. From the image acquired in the middle of the left ventricle (equatorial slice), left ventricular wall thicknesses, chamber diameters, and surface area measurements of the cavities were determined. At autopsy examination, infarct size and tissue water content were determined. The results demonstrate that magnetic resonance imaging has the potential to assess in situ the alterations of left ventricular dimensions and mass after acute myocardial infarction and can be used to document the influence of therapeutic interventions. Cilazapril provided protection against the deleterious remodeling changes such as ventricular dilation and wall thinning consequent to acute myocardial infarction. SN - 0002-8703 UR - https://www.unboundmedicine.com/medline/citation/1534434/Effect_of_cilazapril_on_regional_left_ventricular_wall_thickness_and_chamber_dimension_following_acute_myocardial_infarction:_in_vivo_assessment_using_MRI_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-8703(92)90797-Y DB - PRIME DP - Unbound Medicine ER -