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Immunoglobulin GM genes and IgG antibodies to cytomegalovirus in patients with systemic sclerosis.
Clin Exp Rheumatol. 2004 Jan-Feb; 22(3 Suppl 33):S35-7.CE

Abstract

OBJECTIVE

To determine the role of GM and KM genes--genetic markers of immunoglobulin gamma and kappa chains, respectively--in humoral immunity to human cytomegalovirus (HCMV) in patients with systemic sclerosis (SSc; scleroderma).

METHODS

A total of 137 Caucasian patients with SSc and 145 ethnically matched controls were genotyped for GM f/3, z/17, n+/23+, n-/23-, KM 1, and KM 3 alleles by polymerase chain reaction-restriction fragment length polymorphism and direct DNA sequencing methods. IgG antibodies to HCMV were measured by an enzyme-linked immunosorbent assay.

RESULTS

In SSc patients, GM f,z genotypes were strongly associated with the occurrence of anti-HCMV IgG antibodies. The frequency of the GM f homozygotes was lower (42.2 vs 62.2%; p= 0.02; OR=0.4) and the frequency of the GM f,z heterozygotes was higher (51.1 vs 26.7%; p = 0.006; OR = 2.8) in SSc patients with IgG antibodies to HCMV than in subjects who lacked these antibodies. This association was not observed in the control group. KM and GM n genotypes were not significantly associated with the prevalence of these antibodies.

CONCLUSION

GM f,z alleles or alleles in linkage disequilibrium with them influence the generation of IgG antibodies to HCMV in patients with SSc.

Authors+Show Affiliations

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA. pandeyj@musc.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15344596

Citation

Pandey, J P.. "Immunoglobulin GM Genes and IgG Antibodies to Cytomegalovirus in Patients With Systemic Sclerosis." Clinical and Experimental Rheumatology, vol. 22, no. 3 Suppl 33, 2004, pp. S35-7.
Pandey JP. Immunoglobulin GM genes and IgG antibodies to cytomegalovirus in patients with systemic sclerosis. Clin Exp Rheumatol. 2004;22(3 Suppl 33):S35-7.
Pandey, J. P. (2004). Immunoglobulin GM genes and IgG antibodies to cytomegalovirus in patients with systemic sclerosis. Clinical and Experimental Rheumatology, 22(3 Suppl 33), S35-7.
Pandey JP. Immunoglobulin GM Genes and IgG Antibodies to Cytomegalovirus in Patients With Systemic Sclerosis. Clin Exp Rheumatol. 2004 Jan-Feb;22(3 Suppl 33):S35-7. PubMed PMID: 15344596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulin GM genes and IgG antibodies to cytomegalovirus in patients with systemic sclerosis. A1 - Pandey,J P, PY - 2004/9/4/pubmed PY - 2004/12/16/medline PY - 2004/9/4/entrez SP - S35 EP - 7 JF - Clinical and experimental rheumatology JO - Clin Exp Rheumatol VL - 22 IS - 3 Suppl 33 N2 - OBJECTIVE: To determine the role of GM and KM genes--genetic markers of immunoglobulin gamma and kappa chains, respectively--in humoral immunity to human cytomegalovirus (HCMV) in patients with systemic sclerosis (SSc; scleroderma). METHODS: A total of 137 Caucasian patients with SSc and 145 ethnically matched controls were genotyped for GM f/3, z/17, n+/23+, n-/23-, KM 1, and KM 3 alleles by polymerase chain reaction-restriction fragment length polymorphism and direct DNA sequencing methods. IgG antibodies to HCMV were measured by an enzyme-linked immunosorbent assay. RESULTS: In SSc patients, GM f,z genotypes were strongly associated with the occurrence of anti-HCMV IgG antibodies. The frequency of the GM f homozygotes was lower (42.2 vs 62.2%; p= 0.02; OR=0.4) and the frequency of the GM f,z heterozygotes was higher (51.1 vs 26.7%; p = 0.006; OR = 2.8) in SSc patients with IgG antibodies to HCMV than in subjects who lacked these antibodies. This association was not observed in the control group. KM and GM n genotypes were not significantly associated with the prevalence of these antibodies. CONCLUSION: GM f,z alleles or alleles in linkage disequilibrium with them influence the generation of IgG antibodies to HCMV in patients with SSc. SN - 0392-856X UR - https://www.unboundmedicine.com/medline/citation/15344596/Immunoglobulin_GM_genes_and_IgG_antibodies_to_cytomegalovirus_in_patients_with_systemic_sclerosis_ L2 - http://www.diseaseinfosearch.org/result/2275 DB - PRIME DP - Unbound Medicine ER -