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Taurine depletion and cardiovascular disease in adult cats fed a potassium-depleted acidified diet.
Am J Vet Res. 1992 Mar; 53(3):402-5.AJ

Abstract

Although low plasma taurine concentrations have been associated with congestive cardiomyopathy in cats, the cause of taurine depletion in cats consuming adequate quantities of taurine is unknown. Taurine depletion and cardiovascular disease (cardiomyopathy and thromboembolism) developed unexpectedly in 3 of 6 healthy adult cats during a potassium-depletion study. Plasma taurine concentration decreased significantly (P less than 0.05) and rapidly over an 8-week period (from 98 to 36 nmol/ml) in 6 cats that consumed a potassium-deficient diet (0.20% potassium, dry matter basis) that was acidified with 0.8% ammonium chloride, despite containing dietary taurine concentrations (0.12% dry matter basis) in excess of amounts currently recommended. Taurine concentrations were significantly lower in cats fed the acidified diet than in 6 cats fed a potassium-deficient diet that was not acidified (36 nmol/ml vs 75 nmol/ml) after 8 weeks. In addition, plasma taurine concentrations did not decrease over a 6-month period in 8 cats that were fed a potassium-replete diet with acidifier. Plasma taurine concentrations were lowest in 3 cats that died of cardiovascular disease in the group receiving potassium-deficient, acidified diets. These data indicated an association between taurine and potassium balance in cats and suggested that development of taurine depletion and cardiovascular disease may be linked to concurrent potassium depletion.

Authors+Show Affiliations

Department of Pathology, Colorado State University, Fort Collins 80523.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1534475

Citation

Dow, S W., et al. "Taurine Depletion and Cardiovascular Disease in Adult Cats Fed a Potassium-depleted Acidified Diet." American Journal of Veterinary Research, vol. 53, no. 3, 1992, pp. 402-5.
Dow SW, Fettman MJ, Smith KR, et al. Taurine depletion and cardiovascular disease in adult cats fed a potassium-depleted acidified diet. Am J Vet Res. 1992;53(3):402-5.
Dow, S. W., Fettman, M. J., Smith, K. R., Ching, S. V., Hamar, D. W., & Rogers, Q. R. (1992). Taurine depletion and cardiovascular disease in adult cats fed a potassium-depleted acidified diet. American Journal of Veterinary Research, 53(3), 402-5.
Dow SW, et al. Taurine Depletion and Cardiovascular Disease in Adult Cats Fed a Potassium-depleted Acidified Diet. Am J Vet Res. 1992;53(3):402-5. PubMed PMID: 1534475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurine depletion and cardiovascular disease in adult cats fed a potassium-depleted acidified diet. AU - Dow,S W, AU - Fettman,M J, AU - Smith,K R, AU - Ching,S V, AU - Hamar,D W, AU - Rogers,Q R, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 402 EP - 5 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 53 IS - 3 N2 - Although low plasma taurine concentrations have been associated with congestive cardiomyopathy in cats, the cause of taurine depletion in cats consuming adequate quantities of taurine is unknown. Taurine depletion and cardiovascular disease (cardiomyopathy and thromboembolism) developed unexpectedly in 3 of 6 healthy adult cats during a potassium-depletion study. Plasma taurine concentration decreased significantly (P less than 0.05) and rapidly over an 8-week period (from 98 to 36 nmol/ml) in 6 cats that consumed a potassium-deficient diet (0.20% potassium, dry matter basis) that was acidified with 0.8% ammonium chloride, despite containing dietary taurine concentrations (0.12% dry matter basis) in excess of amounts currently recommended. Taurine concentrations were significantly lower in cats fed the acidified diet than in 6 cats fed a potassium-deficient diet that was not acidified (36 nmol/ml vs 75 nmol/ml) after 8 weeks. In addition, plasma taurine concentrations did not decrease over a 6-month period in 8 cats that were fed a potassium-replete diet with acidifier. Plasma taurine concentrations were lowest in 3 cats that died of cardiovascular disease in the group receiving potassium-deficient, acidified diets. These data indicated an association between taurine and potassium balance in cats and suggested that development of taurine depletion and cardiovascular disease may be linked to concurrent potassium depletion. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/1534475/Taurine_depletion_and_cardiovascular_disease_in_adult_cats_fed_a_potassium_depleted_acidified_diet_ DB - PRIME DP - Unbound Medicine ER -