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Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens.
Clin Exp Allergy. 2004 Sep; 34(9):1415-21.CE

Abstract

BACKGROUND

Artemisia vulgaris is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen. One of them, Art v 3, belongs to the lipid-transfer protein (LTP) family and its prevalence in Artemisia-sensitized patients or its relationship with other LTP allergens is not clear.

OBJECTIVE

To assess the pattern of sensitization to an array of mugwort allergens in a Mediterranean population, and to study the cross-reactivity of Art v 3 with Pru p 3 and Par j 1, relevant LTP allergens in the area.

METHODS

Skin prick test was performed with whole extracts (A. vulgaris, Parietaria judaica and peach) and pure natural allergens Art v 1, Art v 3, Art v 60 kDa and Par j 1 in 24 mugwort-allergic patients from a Mediterranean area. In vitro assays included measurement of specific IgE and ELISA inhibition among LTP allergens.

RESULTS

The three Artemisia allergens elicited a positive skin response in 70-80% of the patients. Seven patients were clearly sensitized to Par j 1 and 11 to Pru p 3. There was no correlation between Par j 1 and Pru p 3 sensitization, but a highly significant correlation was found between peach extract and Art v 3 as regards the skin response. No IgE cross-reactivity was observed between Art v 3/Par j 1 or Pru p 3/Par j 1. In contrast, Art v 3 significantly inhibited the binding to Pru p 3 of IgE from three patients' sera out of six studied, but Pru p 3 was not able to inhibit the IgE binding to Art v 3.

CONCLUSION

Art v 3 is a major mugwort allergen and in some patients with IgE to both Art v 3 and Pru p 3, Art v 3 behaves as the primary sensitizing agent.

Authors+Show Affiliations

Dept. I+D, ALK-Abelló SA, Madrid, Spain. manuel.lombardero@es.alk-abello.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15347375

Citation

Lombardero, M, et al. "Prevalence of Sensitization to Artemisia Allergens Art V 1, Art V 3 and Art V 60 kDa. Cross-reactivity Among Art V 3 and Other Relevant Lipid-transfer Protein Allergens." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 34, no. 9, 2004, pp. 1415-21.
Lombardero M, García-Sellés FJ, Polo F, et al. Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. Clin Exp Allergy. 2004;34(9):1415-21.
Lombardero, M., García-Sellés, F. J., Polo, F., Jimeno, L., Chamorro, M. J., García-Casado, G., Sánchez-Monge, R., Díaz-Perales, A., Salcedo, G., & Barber, D. (2004). Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 34(9), 1415-21.
Lombardero M, et al. Prevalence of Sensitization to Artemisia Allergens Art V 1, Art V 3 and Art V 60 kDa. Cross-reactivity Among Art V 3 and Other Relevant Lipid-transfer Protein Allergens. Clin Exp Allergy. 2004;34(9):1415-21. PubMed PMID: 15347375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of sensitization to Artemisia allergens Art v 1, Art v 3 and Art v 60 kDa. Cross-reactivity among Art v 3 and other relevant lipid-transfer protein allergens. AU - Lombardero,M, AU - García-Sellés,F J, AU - Polo,F, AU - Jimeno,L, AU - Chamorro,M J, AU - García-Casado,G, AU - Sánchez-Monge,R, AU - Díaz-Perales,A, AU - Salcedo,G, AU - Barber,D, PY - 2004/9/7/pubmed PY - 2005/2/8/medline PY - 2004/9/7/entrez SP - 1415 EP - 21 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 34 IS - 9 N2 - BACKGROUND: Artemisia vulgaris is a widespread weed in the Mediterranean area and several allergens have been detected in its pollen. One of them, Art v 3, belongs to the lipid-transfer protein (LTP) family and its prevalence in Artemisia-sensitized patients or its relationship with other LTP allergens is not clear. OBJECTIVE: To assess the pattern of sensitization to an array of mugwort allergens in a Mediterranean population, and to study the cross-reactivity of Art v 3 with Pru p 3 and Par j 1, relevant LTP allergens in the area. METHODS: Skin prick test was performed with whole extracts (A. vulgaris, Parietaria judaica and peach) and pure natural allergens Art v 1, Art v 3, Art v 60 kDa and Par j 1 in 24 mugwort-allergic patients from a Mediterranean area. In vitro assays included measurement of specific IgE and ELISA inhibition among LTP allergens. RESULTS: The three Artemisia allergens elicited a positive skin response in 70-80% of the patients. Seven patients were clearly sensitized to Par j 1 and 11 to Pru p 3. There was no correlation between Par j 1 and Pru p 3 sensitization, but a highly significant correlation was found between peach extract and Art v 3 as regards the skin response. No IgE cross-reactivity was observed between Art v 3/Par j 1 or Pru p 3/Par j 1. In contrast, Art v 3 significantly inhibited the binding to Pru p 3 of IgE from three patients' sera out of six studied, but Pru p 3 was not able to inhibit the IgE binding to Art v 3. CONCLUSION: Art v 3 is a major mugwort allergen and in some patients with IgE to both Art v 3 and Pru p 3, Art v 3 behaves as the primary sensitizing agent. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15347375/Prevalence_of_sensitization_to_Artemisia_allergens_Art_v_1_Art_v_3_and_Art_v_60_kDa__Cross_reactivity_among_Art_v_3_and_other_relevant_lipid_transfer_protein_allergens_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2004&volume=34&issue=9&spage=1415 DB - PRIME DP - Unbound Medicine ER -