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Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust.
Clin Exp Allergy 2004; 34(9):1444-7CE

Abstract

BACKGROUND

Exposure to house dust mite (HDM) allergens can lead to the development of allergic complaints. Mattress covers seem to be an obvious option for lowering allergen exposure in sensitized individuals. Previous studies have shown that Dermatophagoides pteronissinus was the most prevalent HDM species in the Netherlands.

OBJECTIVE

In the present study, we investigated the effect of mattress covers on Der p 1 and Der f 1 concentrations in dust samples in three areas in the Netherlands; Groningen, Utrecht and Rotterdam.

METHODS

Dust was obtained from mattresses of 277 patients at the beginning of the study and after 12 months of the placebo-controlled intervention. It was analysed for allergen content by immunoassay. The differential effect of the intervention on Der p 1 vs. Der f 1 was analysed in a subgroup with Der p 1+Der f 1>1 microg/g dust (N=161). It was tested whether the intervention caused a significant change in the Der f 1/Der p 1 ratio.

RESULTS

At t=0 we found very similar levels of the group 1 allergens of both species. The relatively high prevalence of D. farinae in our study was geographically restricted: the median Der f 1/Der p 1 ratio was 11.1 in the Rotterdam area compared with 1.32 in the Utrecht area and 0.33 in the Groningen area. Analysis of our data showed that the favourable intervention effect found for the combined allergen data (reduction factor=2.9, P<0.001) is essentially due to a favourable effect of the intervention on the Der f 1 levels only (reduction factor=3.6, P<0.001). The effect on the Der p 1 level was remarkably small (reduction factor: 1.2, P=0.48). In the intervention group, the Der f 1/Der p 1 ratio decreased after 12 months by a factor 2.0, whereas in the placebo group it increased (probability of the intervention effect: P<0.005).

CONCLUSION

Mite-impermeable covers are more effective in reducing the level of Der f 1 than that of Der p 1.

Authors+Show Affiliations

Department of Allergology, University Hospital, Groningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15347379

Citation

Tempels-Pavlica, Z, et al. "Differential Effect of Mattress Covers On the Level of Der P 1 and Der F 1 in Dust." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 34, no. 9, 2004, pp. 1444-7.
Tempels-Pavlica Z, Oosting AJ, Terreehorst I, et al. Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust. Clin Exp Allergy. 2004;34(9):1444-7.
Tempels-Pavlica, Z., Oosting, A. J., Terreehorst, I., van Wijk, R. G., Bruijnzeel-Koomen, C. A., de Monchy, J. G., & Aalberse, R. C. (2004). Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 34(9), pp. 1444-7.
Tempels-Pavlica Z, et al. Differential Effect of Mattress Covers On the Level of Der P 1 and Der F 1 in Dust. Clin Exp Allergy. 2004;34(9):1444-7. PubMed PMID: 15347379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust. AU - Tempels-Pavlica,Z, AU - Oosting,A J, AU - Terreehorst,I, AU - van Wijk,R Gerth, AU - Bruijnzeel-Koomen,C A F M, AU - de Monchy,J G R, AU - Aalberse,R C, PY - 2004/9/7/pubmed PY - 2005/2/8/medline PY - 2004/9/7/entrez SP - 1444 EP - 7 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 34 IS - 9 N2 - BACKGROUND: Exposure to house dust mite (HDM) allergens can lead to the development of allergic complaints. Mattress covers seem to be an obvious option for lowering allergen exposure in sensitized individuals. Previous studies have shown that Dermatophagoides pteronissinus was the most prevalent HDM species in the Netherlands. OBJECTIVE: In the present study, we investigated the effect of mattress covers on Der p 1 and Der f 1 concentrations in dust samples in three areas in the Netherlands; Groningen, Utrecht and Rotterdam. METHODS: Dust was obtained from mattresses of 277 patients at the beginning of the study and after 12 months of the placebo-controlled intervention. It was analysed for allergen content by immunoassay. The differential effect of the intervention on Der p 1 vs. Der f 1 was analysed in a subgroup with Der p 1+Der f 1>1 microg/g dust (N=161). It was tested whether the intervention caused a significant change in the Der f 1/Der p 1 ratio. RESULTS: At t=0 we found very similar levels of the group 1 allergens of both species. The relatively high prevalence of D. farinae in our study was geographically restricted: the median Der f 1/Der p 1 ratio was 11.1 in the Rotterdam area compared with 1.32 in the Utrecht area and 0.33 in the Groningen area. Analysis of our data showed that the favourable intervention effect found for the combined allergen data (reduction factor=2.9, P<0.001) is essentially due to a favourable effect of the intervention on the Der f 1 levels only (reduction factor=3.6, P<0.001). The effect on the Der p 1 level was remarkably small (reduction factor: 1.2, P=0.48). In the intervention group, the Der f 1/Der p 1 ratio decreased after 12 months by a factor 2.0, whereas in the placebo group it increased (probability of the intervention effect: P<0.005). CONCLUSION: Mite-impermeable covers are more effective in reducing the level of Der f 1 than that of Der p 1. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15347379/Differential_effect_of_mattress_covers_on_the_level_of_Der_p_1_and_Der_f_1_in_dust_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0954-7894&amp;date=2004&amp;volume=34&amp;issue=9&amp;spage=1444 DB - PRIME DP - Unbound Medicine ER -