Citation
Cho, H R., et al. "Blockade of 4-1BB (CD137)/4-1BB Ligand Interactions Increases Allograft Survival." Transplant International : Official Journal of the European Society for Organ Transplantation, vol. 17, no. 7, 2004, pp. 351-61.
Cho HR, Kwon B, Yagita H, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 2004;17(7):351-61.
Cho, H. R., Kwon, B., Yagita, H., La, S., Lee, E. A., Kim, J. E., Akiba, H., Kim, J., Suh, J. H., Vinay, D. S., Ju, S. A., Kim, B. S., Mittler, R. S., Okumura, K., & Kwon, B. S. (2004). Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transplant International : Official Journal of the European Society for Organ Transplantation, 17(7), 351-61.
Cho HR, et al. Blockade of 4-1BB (CD137)/4-1BB Ligand Interactions Increases Allograft Survival. Transpl Int. 2004;17(7):351-61. PubMed PMID: 15349720.
TY - JOUR
T1 - Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.
AU - Cho,H R,
AU - Kwon,B,
AU - Yagita,H,
AU - La,S,
AU - Lee,E A,
AU - Kim,J-E,
AU - Akiba,H,
AU - Kim,J,
AU - Suh,J-H,
AU - Vinay,D S,
AU - Ju,S-A,
AU - Kim,B-S,
AU - Mittler,R S,
AU - Okumura,K,
AU - Kwon,B S,
Y1 - 2004/07/31/
PY - 2003/06/05/received
PY - 2004/02/12/revised
PY - 2004/03/05/accepted
PY - 2004/9/7/pubmed
PY - 2005/2/19/medline
PY - 2004/9/7/entrez
SP - 351
EP - 61
JF - Transplant international : official journal of the European Society for Organ Transplantation
JO - Transpl Int
VL - 17
IS - 7
N2 - We investigated the role of 4-1BB, a T cell co-stimulatory molecule, in alloimmune responses. In vivo mixed lymphocyte reactions showed that 4-1BB was preferentially expressed on actively dividing CD4(+) and CD8(+) T cells. Furthermore, following alloantigen challenge, the draining lymph nodes contained subpopulations of 4-1BB-expressing CD4(+) and CD8(+) T cells. 4-1BB-deficient C57BL/6 mice showed a delayed rejection of cardiac transplants mismatched for the major histocompatibility complex. Longer transplant survival was induced by blockade of 4-1BB/4-1BB ligand (4-1BBL) interactions using an anti-4-1BBL monoclonal antibody. Histological analysis showed that prolonged transplant survival in the 4-1BB-deficient and anti-4-1BBL-treated mice correlated with reduced lymphocytic infiltration and vasculitis in the donor heart tissue. Taken together, our data suggest that blockade of 4-1BB/4-1BBL interactions inhibited the expansion of alloreactive T cells and reduced CTL activity against host alloantigen, which in turn resulted in the prolongation of allograft survival. Blockade of the 4-1BB co-stimulatory pathway may be useful for preventing allograft rejection.
SN - 0934-0874
UR - https://www.unboundmedicine.com/medline/citation/15349720/Blockade_of_4_1BB__CD137_/4_1BB_ligand_interactions_increases_allograft_survival_
L2 - http://link.springer.com/article/10.1007/s00147-004-0726-3
DB - PRIME
DP - Unbound Medicine
ER -