Tags

Type your tag names separated by a space and hit enter

Diagnosis and therapy of alcoholic liver disease.
Semin Liver Dis 2004; 24(3):233-47SL

Abstract

Alcoholic liver disease (ALD) presents considerable challenges to clinicians. Screening for alcohol abuse and alcoholism should be routine and repeated annually with close attention to signs and symptoms of liver disease. In patients with evidence of liver dysfunction or injury, consideration should be given to performance of liver biopsy for diagnosis and prognosis and prior to initiation of medication with the potential for significant side effects. Therapy depends on the spectrum of pathological liver injury: alcoholic fatty liver, alcoholic hepatitis, and cirrhosis. Abstention is the foundation of therapy for an alcohol problem. Alcoholic fatty liver should improve with abstention, but the similarity to the pathogenesis of nonalcoholic fatty liver and potential for progressive injury merits consideration of lipotropic agents. The continuing mortality, poor acceptance of corticosteroids, and identification of tumor necrosis factor-alpha (TNF-alpha) as an integral component has led to studies of pentoxifylline and, recently, anti-TNF antibody to neutralize cytokines in the therapy of severe alcoholic hepatitis. Antioxidant therapy of alcoholic cirrhosis has significant promise but will require large clinical trials.

Authors+Show Affiliations

University of Nebraska College of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15349802

Citation

Levitsky, Josh, and Mark E. Mailliard. "Diagnosis and Therapy of Alcoholic Liver Disease." Seminars in Liver Disease, vol. 24, no. 3, 2004, pp. 233-47.
Levitsky J, Mailliard ME. Diagnosis and therapy of alcoholic liver disease. Semin Liver Dis. 2004;24(3):233-47.
Levitsky, J., & Mailliard, M. E. (2004). Diagnosis and therapy of alcoholic liver disease. Seminars in Liver Disease, 24(3), pp. 233-47.
Levitsky J, Mailliard ME. Diagnosis and Therapy of Alcoholic Liver Disease. Semin Liver Dis. 2004;24(3):233-47. PubMed PMID: 15349802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and therapy of alcoholic liver disease. AU - Levitsky,Josh, AU - Mailliard,Mark E, PY - 2004/9/7/pubmed PY - 2004/12/16/medline PY - 2004/9/7/entrez SP - 233 EP - 47 JF - Seminars in liver disease JO - Semin. Liver Dis. VL - 24 IS - 3 N2 - Alcoholic liver disease (ALD) presents considerable challenges to clinicians. Screening for alcohol abuse and alcoholism should be routine and repeated annually with close attention to signs and symptoms of liver disease. In patients with evidence of liver dysfunction or injury, consideration should be given to performance of liver biopsy for diagnosis and prognosis and prior to initiation of medication with the potential for significant side effects. Therapy depends on the spectrum of pathological liver injury: alcoholic fatty liver, alcoholic hepatitis, and cirrhosis. Abstention is the foundation of therapy for an alcohol problem. Alcoholic fatty liver should improve with abstention, but the similarity to the pathogenesis of nonalcoholic fatty liver and potential for progressive injury merits consideration of lipotropic agents. The continuing mortality, poor acceptance of corticosteroids, and identification of tumor necrosis factor-alpha (TNF-alpha) as an integral component has led to studies of pentoxifylline and, recently, anti-TNF antibody to neutralize cytokines in the therapy of severe alcoholic hepatitis. Antioxidant therapy of alcoholic cirrhosis has significant promise but will require large clinical trials. SN - 0272-8087 UR - https://www.unboundmedicine.com/medline/citation/15349802/Diagnosis_and_therapy_of_alcoholic_liver_disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-832937 DB - PRIME DP - Unbound Medicine ER -