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Oral contraceptive use and breast cancer risk: a meta-analysis of variations with age at diagnosis, parity and total duration of oral contraceptive use.
Br J Obstet Gynaecol. 1992 Mar; 99(3):239-46.BJ

Abstract

OBJECTIVE

To review published reports of risk of breast cancer with oral contraceptive use.

DESIGN

Meta-analysis of study results, using regression techniques to explore the inter-study heterogeneity.

SETTING

Twenty-seven epidemiological studies of breast cancer risk and oral contraceptive use published 1980-1989.

MAIN OUTCOME MEASURES

Relative risk of breast cancer with oral contraceptive use; variations by age at diagnosis, parity, and total duration of use, and with study design characteristics.

RESULTS

The overall relative risk estimate was 1.16 (95% CI 1.07-1.25) for the less than 45 years group, 1.21 (95% CI 0.99-1.47) for the nulliparous subgroup, and 1.27 (95% CI 1.12-1.44) for durations of use of more than 8 years. Source of subjects, their marital status, the type of study, data collection methods, matching for geographical area, the number of adjustment factors used in the study analysis, the country of study and the calendar period in which the study ended were all important explanatory factors for inter-study variation, but a substantial proportion of inter-study variation remained unexplained.

CONCLUSIONS

These meta-analyses suggest that risk of breast cancer may be raised by around 20% in younger, nulliparous and long use duration subgroups of oral contraceptive users. Risk estimates appear to be influenced by several study design factors, which should be considered carefully in designing and reviewing future studies.

Authors+Show Affiliations

Department of Public Health Sciences, St George's Hospital Medical School, London, UK.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1534994

Citation

Rushton, L, and D R. Jones. "Oral Contraceptive Use and Breast Cancer Risk: a Meta-analysis of Variations With Age at Diagnosis, Parity and Total Duration of Oral Contraceptive Use." British Journal of Obstetrics and Gynaecology, vol. 99, no. 3, 1992, pp. 239-46.
Rushton L, Jones DR. Oral contraceptive use and breast cancer risk: a meta-analysis of variations with age at diagnosis, parity and total duration of oral contraceptive use. Br J Obstet Gynaecol. 1992;99(3):239-46.
Rushton, L., & Jones, D. R. (1992). Oral contraceptive use and breast cancer risk: a meta-analysis of variations with age at diagnosis, parity and total duration of oral contraceptive use. British Journal of Obstetrics and Gynaecology, 99(3), 239-46.
Rushton L, Jones DR. Oral Contraceptive Use and Breast Cancer Risk: a Meta-analysis of Variations With Age at Diagnosis, Parity and Total Duration of Oral Contraceptive Use. Br J Obstet Gynaecol. 1992;99(3):239-46. PubMed PMID: 1534994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive use and breast cancer risk: a meta-analysis of variations with age at diagnosis, parity and total duration of oral contraceptive use. AU - Rushton,L, AU - Jones,D R, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez KW - Age Factors KW - Biology KW - Breast Cancer KW - Cancer KW - Contraception KW - Contraception Continuation KW - Contraceptive Methods KW - Contraceptive Usage KW - Data Analysis KW - Demographic Factors KW - Diseases KW - Family Planning KW - Fertility KW - Fertility Measurements KW - Literature Review KW - Neoplasms KW - Oral Contraceptives KW - Parity KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Risk Factors SP - 239 EP - 46 JF - British journal of obstetrics and gynaecology JO - Br J Obstet Gynaecol VL - 99 IS - 3 N2 - OBJECTIVE: To review published reports of risk of breast cancer with oral contraceptive use. DESIGN: Meta-analysis of study results, using regression techniques to explore the inter-study heterogeneity. SETTING: Twenty-seven epidemiological studies of breast cancer risk and oral contraceptive use published 1980-1989. MAIN OUTCOME MEASURES: Relative risk of breast cancer with oral contraceptive use; variations by age at diagnosis, parity, and total duration of use, and with study design characteristics. RESULTS: The overall relative risk estimate was 1.16 (95% CI 1.07-1.25) for the less than 45 years group, 1.21 (95% CI 0.99-1.47) for the nulliparous subgroup, and 1.27 (95% CI 1.12-1.44) for durations of use of more than 8 years. Source of subjects, their marital status, the type of study, data collection methods, matching for geographical area, the number of adjustment factors used in the study analysis, the country of study and the calendar period in which the study ended were all important explanatory factors for inter-study variation, but a substantial proportion of inter-study variation remained unexplained. CONCLUSIONS: These meta-analyses suggest that risk of breast cancer may be raised by around 20% in younger, nulliparous and long use duration subgroups of oral contraceptive users. Risk estimates appear to be influenced by several study design factors, which should be considered carefully in designing and reviewing future studies. SN - 0306-5456 UR - https://www.unboundmedicine.com/medline/citation/1534994/Oral_contraceptive_use_and_breast_cancer_risk:_a_meta_analysis_of_variations_with_age_at_diagnosis_parity_and_total_duration_of_oral_contraceptive_use_ L2 - http://www.diseaseinfosearch.org/result/5395 DB - PRIME DP - Unbound Medicine ER -