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Hypothyroidism and the development of open-angle glaucoma in a male population.

Abstract

PURPOSE

To determine if hypothyroidism is associated with an increased risk of glaucoma using a large cohort of patients.

DESIGN

Nested case-control study.

PARTICIPANTS

Patients seen at the Veterans Affairs Medical Center in Birmingham, Alabama with newly diagnosed glaucoma between 1997 and 2001 were selected (n = 590) and age-matched to nonglaucoma controls (n = 5897).

METHODS

Patient information was extracted from the Birmingham Veterans Affairs Medical Center data files containing demographic, clinical, and medication information. An index date was assigned to the glaucoma subjects corresponding to the time of diagnosis. Patients who had a glaucoma diagnosis before the observation period of the study were excluded. Ten controls were randomly selected for each patient and matched on age (+/-1 year) and an encounter on or before the index date of the matched case.

MAIN OUTCOME MEASURES

Odds ratios (ORs) for the association between the prior diagnosis of hypothyroidism and the risk of developing glaucoma with adjustment for the presence of diabetes, lipid metabolism disorders, hypertension, cardiovascular disease, cerebrovascular disease, arterial disease, and migraines.

RESULTS

After adjustment for the other potential risk factors, patients were significantly more likely to have prior hypothyroidism than controls (OR, 1.40; 95% confidence interval, 1.01-1.97).

CONCLUSIONS

Our study has demonstrated a significantly greater risk of subjects with a preexisting diagnosis of hypothyroidism developing glaucoma, compared with controls, in a large Veterans Affairs Medical Center population.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, 35294-0009, USA. cgirkin@uabmc.edu

    , , ,

    Source

    Ophthalmology 111:9 2004 Sep pg 1649-52

    MeSH

    Aged
    Aged, 80 and over
    Case-Control Studies
    Glaucoma, Open-Angle
    Humans
    Hypothyroidism
    Intraocular Pressure
    Male
    Middle Aged
    Odds Ratio
    Random Allocation
    Risk Factors
    Thyroxine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15350317

    Citation

    Girkin, Christopher A., et al. "Hypothyroidism and the Development of Open-angle Glaucoma in a Male Population." Ophthalmology, vol. 111, no. 9, 2004, pp. 1649-52.
    Girkin CA, McGwin G, McNeal SF, et al. Hypothyroidism and the development of open-angle glaucoma in a male population. Ophthalmology. 2004;111(9):1649-52.
    Girkin, C. A., McGwin, G., McNeal, S. F., Lee, P. P., & Owsley, C. (2004). Hypothyroidism and the development of open-angle glaucoma in a male population. Ophthalmology, 111(9), pp. 1649-52.
    Girkin CA, et al. Hypothyroidism and the Development of Open-angle Glaucoma in a Male Population. Ophthalmology. 2004;111(9):1649-52. PubMed PMID: 15350317.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hypothyroidism and the development of open-angle glaucoma in a male population. AU - Girkin,Christopher A, AU - McGwin,Gerald,Jr AU - McNeal,Sandre F, AU - Lee,Paul P, AU - Owsley,Cynthia, PY - 2003/02/11/received PY - 2004/05/14/accepted PY - 2004/9/8/pubmed PY - 2004/9/15/medline PY - 2004/9/8/entrez SP - 1649 EP - 52 JF - Ophthalmology JO - Ophthalmology VL - 111 IS - 9 N2 - PURPOSE: To determine if hypothyroidism is associated with an increased risk of glaucoma using a large cohort of patients. DESIGN: Nested case-control study. PARTICIPANTS: Patients seen at the Veterans Affairs Medical Center in Birmingham, Alabama with newly diagnosed glaucoma between 1997 and 2001 were selected (n = 590) and age-matched to nonglaucoma controls (n = 5897). METHODS: Patient information was extracted from the Birmingham Veterans Affairs Medical Center data files containing demographic, clinical, and medication information. An index date was assigned to the glaucoma subjects corresponding to the time of diagnosis. Patients who had a glaucoma diagnosis before the observation period of the study were excluded. Ten controls were randomly selected for each patient and matched on age (+/-1 year) and an encounter on or before the index date of the matched case. MAIN OUTCOME MEASURES: Odds ratios (ORs) for the association between the prior diagnosis of hypothyroidism and the risk of developing glaucoma with adjustment for the presence of diabetes, lipid metabolism disorders, hypertension, cardiovascular disease, cerebrovascular disease, arterial disease, and migraines. RESULTS: After adjustment for the other potential risk factors, patients were significantly more likely to have prior hypothyroidism than controls (OR, 1.40; 95% confidence interval, 1.01-1.97). CONCLUSIONS: Our study has demonstrated a significantly greater risk of subjects with a preexisting diagnosis of hypothyroidism developing glaucoma, compared with controls, in a large Veterans Affairs Medical Center population. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15350317/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)00925-X DB - PRIME DP - Unbound Medicine ER -