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A new approach to evaluating the toxicity and genotoxicity of disinfected drinking water.
Water Res. 2004 Oct; 38(17):3809-19.WR

Abstract

The aim of this study was to evaluate the formation of toxic and genotoxic compounds in surface drinking waters treated with two widely used disinfectants, sodium hypochlorite (NaClO) and chlorine dioxide (ClO(2)), and a new disinfectant, peracetic acid (PAA). For this purpose a pilot plant was set up to add these biocides continuously to pre-filtered lake water flowing into three different basins. During three seasonal experiments, short-term in vivo tests (with plant, fish and molluscs) and in vitro tests (with bacteria, yeast and human cells) were carried out to evaluate the formation of genotoxic disinfection by-products (DBPs). Gas chromatography/mass spectrometry (GC/MS) was used to identify DBPs produced during the different treatments, microbiological analyses were performed to test the biocidal activity of the disinfectants, and chemical analyses were carried out to evaluate the quality of the water. The pilot drinking water plant under study was useful in studying the toxicity and genotoxicity of disinfected drinking water with this combined chemical/biotoxicological approach. This paper describes the setting up of the pilot plant and sets out/reports the results of the microbiological and chemical analyses.

Authors+Show Affiliations

Monarca S
Department of Hygiene and Public Health, University of Perugia, Via del Giochetto 06126, Italy. monarca@unipg.it
Zani C
No affiliation info available
Richardson SD
No affiliation info available
Thruston AD
No affiliation info available
Moretti M
No affiliation info available
Feretti D
No affiliation info available
Villarini M
No affiliation info available

MeSH

AnimalsBacteriaCell Culture TechniquesChlorine CompoundsDisinfectantsFishesHumansMolluscaMutagenicity TestsOxidesPlantsRisk AssessmentSodium HypochloriteWater Pollutants, ChemicalWater PurificationYeasts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15350433

Citation

Monarca, Silvano, et al. "A New Approach to Evaluating the Toxicity and Genotoxicity of Disinfected Drinking Water." Water Research, vol. 38, no. 17, 2004, pp. 3809-19.
Monarca S, Zani C, Richardson SD, et al. A new approach to evaluating the toxicity and genotoxicity of disinfected drinking water. Water Res. 2004;38(17):3809-19.
Monarca, S., Zani, C., Richardson, S. D., Thruston, A. D., Moretti, M., Feretti, D., & Villarini, M. (2004). A new approach to evaluating the toxicity and genotoxicity of disinfected drinking water. Water Research, 38(17), 3809-19.
Monarca S, et al. A New Approach to Evaluating the Toxicity and Genotoxicity of Disinfected Drinking Water. Water Res. 2004;38(17):3809-19. PubMed PMID: 15350433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new approach to evaluating the toxicity and genotoxicity of disinfected drinking water. AU - Monarca,Silvano, AU - Zani,Claudia, AU - Richardson,Susan D, AU - Thruston,Alfred D,Jr AU - Moretti,Massimo, AU - Feretti,Donatella, AU - Villarini,Milena, PY - 2004/9/8/pubmed PY - 2004/12/23/medline PY - 2004/9/8/entrez SP - 3809 EP - 19 JF - Water research JO - Water Res VL - 38 IS - 17 N2 - The aim of this study was to evaluate the formation of toxic and genotoxic compounds in surface drinking waters treated with two widely used disinfectants, sodium hypochlorite (NaClO) and chlorine dioxide (ClO(2)), and a new disinfectant, peracetic acid (PAA). For this purpose a pilot plant was set up to add these biocides continuously to pre-filtered lake water flowing into three different basins. During three seasonal experiments, short-term in vivo tests (with plant, fish and molluscs) and in vitro tests (with bacteria, yeast and human cells) were carried out to evaluate the formation of genotoxic disinfection by-products (DBPs). Gas chromatography/mass spectrometry (GC/MS) was used to identify DBPs produced during the different treatments, microbiological analyses were performed to test the biocidal activity of the disinfectants, and chemical analyses were carried out to evaluate the quality of the water. The pilot drinking water plant under study was useful in studying the toxicity and genotoxicity of disinfected drinking water with this combined chemical/biotoxicological approach. This paper describes the setting up of the pilot plant and sets out/reports the results of the microbiological and chemical analyses. SN - 0043-1354 UR - https://www.unboundmedicine.com/medline/citation/15350433/A_new_approach_to_evaluating_the_toxicity_and_genotoxicity_of_disinfected_drinking_water_ DB - PRIME DP - Unbound Medicine ER -