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Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases.
J Nutr Biochem. 2004 Sep; 15(9):506-16.JN

Abstract

Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review.

Authors+Show Affiliations

Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion-Faculty of Medicine, 31096 Haifa, Israel.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15350981

Citation

Weinreb, Orly, et al. "Neurological Mechanisms of Green Tea Polyphenols in Alzheimer's and Parkinson's Diseases." The Journal of Nutritional Biochemistry, vol. 15, no. 9, 2004, pp. 506-16.
Weinreb O, Mandel S, Amit T, et al. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem. 2004;15(9):506-16.
Weinreb, O., Mandel, S., Amit, T., & Youdim, M. B. (2004). Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. The Journal of Nutritional Biochemistry, 15(9), 506-16.
Weinreb O, et al. Neurological Mechanisms of Green Tea Polyphenols in Alzheimer's and Parkinson's Diseases. J Nutr Biochem. 2004;15(9):506-16. PubMed PMID: 15350981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. AU - Weinreb,Orly, AU - Mandel,Silvia, AU - Amit,Tamar, AU - Youdim,Moussa B H, PY - 2004/03/08/received PY - 2004/05/10/revised PY - 2004/05/26/accepted PY - 2004/9/8/pubmed PY - 2005/2/24/medline PY - 2004/9/8/entrez SP - 506 EP - 16 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 15 IS - 9 N2 - Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/15350981/Neurological_mechanisms_of_green_tea_polyphenols_in_Alzheimer's_and_Parkinson's_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955286304001184 DB - PRIME DP - Unbound Medicine ER -