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Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate.
Prev Med. 2004 Oct; 39(4):689-94.PM

Abstract

BACKGROUND

Inadequate maternal vitamin intake during pregnancy has been suggested as a risk factor for cleft lip with or without cleft palate (CLP). The independent role of folate has not been clarified.

METHODS

To investigate the association between maternal folate intake by supplement and food and the risk of CLP offspring, a case-control study was conducted in the Netherlands (1998-2000) among 174 mothers of a child with nonsyndromic CLP and 203 mothers of a child without congenital malformations.

RESULTS

Daily use of a folic acid supplement by mothers starting from 4 weeks before until 8 weeks after conception gave a 47% CLP risk reduction compared to mothers who did not use these supplements [odds ratio (OR): 0.53, 95% confidence interval (CI): 0.33, 0.85]. Ninety-three percent of the users took a supplement containing folic acid only. Dietary folate intake reduced CLP risk independently in a dose-response manner. The largest risk reductions were found on those mothers who had a diet of more than 200 microg folate per day in combination with a folic acid supplement (OR: 0.26, 95% CI: 0.09, 0.72).

CONCLUSIONS

We demonstrated that periconceptional maternal folic acid supplement use was beneficial to reduce the risk for CLP. An additional effect of food folate was shown.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, 6500 HB, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15351534

Citation

van Rooij, Iris A L M., et al. "Periconceptional Folate Intake By Supplement and Food Reduces the Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate." Preventive Medicine, vol. 39, no. 4, 2004, pp. 689-94.
van Rooij IA, Ocké MC, Straatman H, et al. Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. Prev Med. 2004;39(4):689-94.
van Rooij, I. A., Ocké, M. C., Straatman, H., Zielhuis, G. A., Merkus, H. M., & Steegers-Theunissen, R. P. (2004). Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. Preventive Medicine, 39(4), 689-94.
van Rooij IA, et al. Periconceptional Folate Intake By Supplement and Food Reduces the Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate. Prev Med. 2004;39(4):689-94. PubMed PMID: 15351534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. AU - van Rooij,Iris A L M, AU - Ocké,Marga C, AU - Straatman,Huub, AU - Zielhuis,Gerhard A, AU - Merkus,Hans M W M, AU - Steegers-Theunissen,Régine P M, PY - 2004/9/8/pubmed PY - 2005/4/19/medline PY - 2004/9/8/entrez SP - 689 EP - 94 JF - Preventive medicine JO - Prev Med VL - 39 IS - 4 N2 - BACKGROUND: Inadequate maternal vitamin intake during pregnancy has been suggested as a risk factor for cleft lip with or without cleft palate (CLP). The independent role of folate has not been clarified. METHODS: To investigate the association between maternal folate intake by supplement and food and the risk of CLP offspring, a case-control study was conducted in the Netherlands (1998-2000) among 174 mothers of a child with nonsyndromic CLP and 203 mothers of a child without congenital malformations. RESULTS: Daily use of a folic acid supplement by mothers starting from 4 weeks before until 8 weeks after conception gave a 47% CLP risk reduction compared to mothers who did not use these supplements [odds ratio (OR): 0.53, 95% confidence interval (CI): 0.33, 0.85]. Ninety-three percent of the users took a supplement containing folic acid only. Dietary folate intake reduced CLP risk independently in a dose-response manner. The largest risk reductions were found on those mothers who had a diet of more than 200 microg folate per day in combination with a folic acid supplement (OR: 0.26, 95% CI: 0.09, 0.72). CONCLUSIONS: We demonstrated that periconceptional maternal folic acid supplement use was beneficial to reduce the risk for CLP. An additional effect of food folate was shown. SN - 0091-7435 UR - https://www.unboundmedicine.com/medline/citation/15351534/Periconceptional_folate_intake_by_supplement_and_food_reduces_the_risk_of_nonsyndromic_cleft_lip_with_or_without_cleft_palate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091743504001215 DB - PRIME DP - Unbound Medicine ER -