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Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey.
Urology 2004; 64(3):504-9U

Abstract

OBJECTIVES

To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS).

METHODS

We included 2497 men, 60 years old and older, who participated in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and for whom serum concentrations of vitamins A, C, and E, carotenoids, and selenium had been measured previously. Cases were men with three or four of the following symptoms: nocturia, hesitancy, incomplete emptying, and weak stream, but who had never undergone noncancer prostate surgery. Controls were men without symptoms, who had never undergone noncancer prostate surgery. We adjusted for age and race in logistic regression models and used sampling weights.

RESULTS

Serum concentrations of vitamin E (P = 0.03), lycopene (P = 0.06), and selenium (P = 0.03) were lower in men with LUTS compared with controls. Men in the top four quintiles of vitamin E, lycopene, and selenium had a nonstatistically significant 25% to 50% reduced odds of LUTS compared with men in the bottom quintile. Inverse associations were not seen for the other carotenoids or vitamin A. A high serum vitamin C concentration was associated with a lower odds of LUTS in current smokers, but with a nonstatistically significant greater odds in those who never smoked and in former smokers.

CONCLUSIONS

Greater circulating concentrations of vitamin E, lycopene, and selenium, antioxidant micronutrients that are supported in published reports as protecting against prostate cancer, were observed also to be inversely associated with LUTS. The effect modification of the association with vitamin C by cigarette smoking warrants additional examination.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15351580

Citation

Rohrmann, Sabine, et al. "Association Between Serum Concentrations of Micronutrients and Lower Urinary Tract Symptoms in Older Men in the Third National Health and Nutrition Examination Survey." Urology, vol. 64, no. 3, 2004, pp. 504-9.
Rohrmann S, Smit E, Giovannucci E, et al. Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey. Urology. 2004;64(3):504-9.
Rohrmann, S., Smit, E., Giovannucci, E., & Platz, E. A. (2004). Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey. Urology, 64(3), pp. 504-9.
Rohrmann S, et al. Association Between Serum Concentrations of Micronutrients and Lower Urinary Tract Symptoms in Older Men in the Third National Health and Nutrition Examination Survey. Urology. 2004;64(3):504-9. PubMed PMID: 15351580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum concentrations of micronutrients and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey. AU - Rohrmann,Sabine, AU - Smit,Ellen, AU - Giovannucci,Edward, AU - Platz,Elizabeth A, AU - ,, PY - 2004/02/12/received PY - 2004/04/09/accepted PY - 2004/9/8/pubmed PY - 2005/4/19/medline PY - 2004/9/8/entrez SP - 504 EP - 9 JF - Urology JO - Urology VL - 64 IS - 3 N2 - OBJECTIVES: To evaluate the association of serum micronutrients with lower urinary tract symptoms (LUTS). METHODS: We included 2497 men, 60 years old and older, who participated in the Third National Health and Nutrition Examination Survey from 1988 to 1994 and for whom serum concentrations of vitamins A, C, and E, carotenoids, and selenium had been measured previously. Cases were men with three or four of the following symptoms: nocturia, hesitancy, incomplete emptying, and weak stream, but who had never undergone noncancer prostate surgery. Controls were men without symptoms, who had never undergone noncancer prostate surgery. We adjusted for age and race in logistic regression models and used sampling weights. RESULTS: Serum concentrations of vitamin E (P = 0.03), lycopene (P = 0.06), and selenium (P = 0.03) were lower in men with LUTS compared with controls. Men in the top four quintiles of vitamin E, lycopene, and selenium had a nonstatistically significant 25% to 50% reduced odds of LUTS compared with men in the bottom quintile. Inverse associations were not seen for the other carotenoids or vitamin A. A high serum vitamin C concentration was associated with a lower odds of LUTS in current smokers, but with a nonstatistically significant greater odds in those who never smoked and in former smokers. CONCLUSIONS: Greater circulating concentrations of vitamin E, lycopene, and selenium, antioxidant micronutrients that are supported in published reports as protecting against prostate cancer, were observed also to be inversely associated with LUTS. The effect modification of the association with vitamin C by cigarette smoking warrants additional examination. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15351580/Association_between_serum_concentrations_of_micronutrients_and_lower_urinary_tract_symptoms_in_older_men_in_the_Third_National_Health_and_Nutrition_Examination_Survey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429504005047 DB - PRIME DP - Unbound Medicine ER -