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Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
Urology. 2004 Sep; 64(3):510-5.U

Abstract

OBJECTIVES

To determine the effects of diets rich in soy and linseed compared with a control diet on biochemical markers of prostate cancer in men diagnosed with prostate cancer.

METHODS

Twenty-nine men diagnosed with prostate cancer and scheduled to undergo a radical prostatectomy were randomized to one of three groups: soy (high phytoestrogen), soy and linseed (high phytoestrogen), or wheat (low phytoestrogen). A bread was specially manufactured to incorporate 50 g of heat-treated (HT) soy grits or 50 g of HT soy grits and 20 g of linseed as part of the study participant's daily diet. Baseline and preoperative levels of prostate-specific antigen (PSA), free PSA, testosterone, sex hormone-binding globulin, free androgen index, and dihydrotestosterone were measured.

RESULTS

Statistically significant differences were detected between the HT soy grits group and the control wheat group for the percentage of change in total PSA (-12.7% versus 40%, P = 0.02) and the percentage of change in free/total PSA ratio (27.4% versus -15.6%, P = 0.01); and between the HT soy grits group and the HT soy grits and linseed group for the percentage of change in free androgen index (16.4% versus -15.5%, P = 0.04) and the percentage of change in free/total PSA ratio (27.4% versus -10%, P = 0.007).

CONCLUSIONS

The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer. This work provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a reduced risk of prostate cancer development and progression.

Authors+Show Affiliations

International Health and Development Unit, Monash University, Clayton, VIC, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15351581

Citation

Dalais, Fabien S., et al. "Effects of a Diet Rich in Phytoestrogens On Prostate-specific Antigen and Sex Hormones in Men Diagnosed With Prostate Cancer." Urology, vol. 64, no. 3, 2004, pp. 510-5.
Dalais FS, Meliala A, Wattanapenpaiboon N, et al. Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology. 2004;64(3):510-5.
Dalais, F. S., Meliala, A., Wattanapenpaiboon, N., Frydenberg, M., Suter, D. A., Thomson, W. K., & Wahlqvist, M. L. (2004). Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology, 64(3), 510-5.
Dalais FS, et al. Effects of a Diet Rich in Phytoestrogens On Prostate-specific Antigen and Sex Hormones in Men Diagnosed With Prostate Cancer. Urology. 2004;64(3):510-5. PubMed PMID: 15351581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. AU - Dalais,Fabien S, AU - Meliala,Andreanyta, AU - Wattanapenpaiboon,Naiyana, AU - Frydenberg,Mark, AU - Suter,David A I, AU - Thomson,William K, AU - Wahlqvist,Mark L, PY - 2003/08/04/received PY - 2004/04/07/accepted PY - 2004/9/8/pubmed PY - 2005/4/19/medline PY - 2004/9/8/entrez SP - 510 EP - 5 JF - Urology JO - Urology VL - 64 IS - 3 N2 - OBJECTIVES: To determine the effects of diets rich in soy and linseed compared with a control diet on biochemical markers of prostate cancer in men diagnosed with prostate cancer. METHODS: Twenty-nine men diagnosed with prostate cancer and scheduled to undergo a radical prostatectomy were randomized to one of three groups: soy (high phytoestrogen), soy and linseed (high phytoestrogen), or wheat (low phytoestrogen). A bread was specially manufactured to incorporate 50 g of heat-treated (HT) soy grits or 50 g of HT soy grits and 20 g of linseed as part of the study participant's daily diet. Baseline and preoperative levels of prostate-specific antigen (PSA), free PSA, testosterone, sex hormone-binding globulin, free androgen index, and dihydrotestosterone were measured. RESULTS: Statistically significant differences were detected between the HT soy grits group and the control wheat group for the percentage of change in total PSA (-12.7% versus 40%, P = 0.02) and the percentage of change in free/total PSA ratio (27.4% versus -15.6%, P = 0.01); and between the HT soy grits group and the HT soy grits and linseed group for the percentage of change in free androgen index (16.4% versus -15.5%, P = 0.04) and the percentage of change in free/total PSA ratio (27.4% versus -10%, P = 0.007). CONCLUSIONS: The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer. This work provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a reduced risk of prostate cancer development and progression. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15351581/Effects_of_a_diet_rich_in_phytoestrogens_on_prostate_specific_antigen_and_sex_hormones_in_men_diagnosed_with_prostate_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429504004364 DB - PRIME DP - Unbound Medicine ER -