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Prostate-specific antigen, sex steroid hormones, and the insulin-like growth factor axis in U.S.-born, Jamaican, and Haitian black men: a pilot study.
Urology. 2004 Sep; 64(3):522-7.U

Abstract

OBJECTIVES

African-Caribbean men have a risk of prostate cancer comparable to that of African-American men. To begin exploring potential risk factors for prostate cancer in these high-risk black subgroups, we conducted a pilot study in Brooklyn, New York, a community with large numbers of African-Americans and immigrants from Jamaica and Haiti.

METHODS

Black men, 35 to 65 years of age, who were born in the United States, Jamaica, or Haiti were recruited in Brooklyn. The subjects' serum samples were analyzed for prostate-specific antigen (PSA) and the following hormones, which may be related to prostate cancer: testosterone, sex hormone-binding globulin, 3alpha-androstanediol glucuronide, insulin-like growth factor-1 (IGF-1), and IGF-binding protein-3 (IGFBP-3). Subgroup differences in PSA and hormonal levels, adjusted for relevant covariates, were explored using analysis of variance techniques.

RESULTS

For 3 months, we recruited 21 U.S.-born, 20 Jamaican-born, and 24 Haitian-born black men using various methods. The mean age-adjusted PSA level was 1.04 ng/mL in the U.S.-born men, 1.09 ng/mL in the Jamaican-born men, and 0.85 ng/mL in the Haitian-born men (P = 0.55). The mean age-adjusted hormone levels, as well as testosterone/sex hormone-binding globulin and IGF-1/IGFBP-3 ratios, also were not significantly different statistically across the subgroups.

CONCLUSIONS

It is feasible to conduct epidemiologic studies of prostate cancer in these high-risk black subgroups in Brooklyn. Our preliminary data suggest that the serum levels of PSA and potential hormonal risk factors are similar among U.S.-born, Jamaican-born, and Haitian-born black men. Larger follow-up studies are being planned to confirm these findings.

Authors+Show Affiliations

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15351583

Citation

Chen, Allen C., et al. "Prostate-specific Antigen, Sex Steroid Hormones, and the Insulin-like Growth Factor Axis in U.S.-born, Jamaican, and Haitian Black Men: a Pilot Study." Urology, vol. 64, no. 3, 2004, pp. 522-7.
Chen AC, MacChia RJ, Conway F, et al. Prostate-specific antigen, sex steroid hormones, and the insulin-like growth factor axis in U.S.-born, Jamaican, and Haitian black men: a pilot study. Urology. 2004;64(3):522-7.
Chen, A. C., MacChia, R. J., Conway, F., Magai, C., Desai, M., & Neugut, A. I. (2004). Prostate-specific antigen, sex steroid hormones, and the insulin-like growth factor axis in U.S.-born, Jamaican, and Haitian black men: a pilot study. Urology, 64(3), 522-7.
Chen AC, et al. Prostate-specific Antigen, Sex Steroid Hormones, and the Insulin-like Growth Factor Axis in U.S.-born, Jamaican, and Haitian Black Men: a Pilot Study. Urology. 2004;64(3):522-7. PubMed PMID: 15351583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prostate-specific antigen, sex steroid hormones, and the insulin-like growth factor axis in U.S.-born, Jamaican, and Haitian black men: a pilot study. AU - Chen,Allen C, AU - MacChia,Richard J, AU - Conway,Francine, AU - Magai,Carol, AU - Desai,Manisha, AU - Neugut,Alfred I, PY - 2004/02/25/received PY - 2004/04/05/accepted PY - 2004/9/8/pubmed PY - 2005/4/19/medline PY - 2004/9/8/entrez SP - 522 EP - 7 JF - Urology JO - Urology VL - 64 IS - 3 N2 - OBJECTIVES: African-Caribbean men have a risk of prostate cancer comparable to that of African-American men. To begin exploring potential risk factors for prostate cancer in these high-risk black subgroups, we conducted a pilot study in Brooklyn, New York, a community with large numbers of African-Americans and immigrants from Jamaica and Haiti. METHODS: Black men, 35 to 65 years of age, who were born in the United States, Jamaica, or Haiti were recruited in Brooklyn. The subjects' serum samples were analyzed for prostate-specific antigen (PSA) and the following hormones, which may be related to prostate cancer: testosterone, sex hormone-binding globulin, 3alpha-androstanediol glucuronide, insulin-like growth factor-1 (IGF-1), and IGF-binding protein-3 (IGFBP-3). Subgroup differences in PSA and hormonal levels, adjusted for relevant covariates, were explored using analysis of variance techniques. RESULTS: For 3 months, we recruited 21 U.S.-born, 20 Jamaican-born, and 24 Haitian-born black men using various methods. The mean age-adjusted PSA level was 1.04 ng/mL in the U.S.-born men, 1.09 ng/mL in the Jamaican-born men, and 0.85 ng/mL in the Haitian-born men (P = 0.55). The mean age-adjusted hormone levels, as well as testosterone/sex hormone-binding globulin and IGF-1/IGFBP-3 ratios, also were not significantly different statistically across the subgroups. CONCLUSIONS: It is feasible to conduct epidemiologic studies of prostate cancer in these high-risk black subgroups in Brooklyn. Our preliminary data suggest that the serum levels of PSA and potential hormonal risk factors are similar among U.S.-born, Jamaican-born, and Haitian-born black men. Larger follow-up studies are being planned to confirm these findings. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/15351583/Prostate_specific_antigen_sex_steroid_hormones_and_the_insulin_like_growth_factor_axis_in_U_S__born_Jamaican_and_Haitian_black_men:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090429504004273 DB - PRIME DP - Unbound Medicine ER -