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A longitudinal study of Alzheimer's disease: rates of cognitive and functional decline.
Int J Geriatr Psychiatry. 2004 Sep; 19(9):817-24.IJ

Abstract

OBJECTIVE

To measure rates of decline in cognition and function in patients with Alzheimer's disease (AD) and to investigate their accelerating risk factors in Korea.

METHODS

This study presents longitudinal data on a community-based sample of 107 patients with AD, followed at 6 months and 12 months. The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), the Mini Mental State Examination (MMSE) and the Disability Assessment for Dementia Scale (DAD) were given. Mixed model analyses were conducted using the following independent variables: times of repeated assessment (0, 6 or 12 months), severity of dementia assessed by the Functional Assessment Staging (FAST) and individual indicators as covariates.

RESULTS

Average annual rates of decline in the MMSE, the ADAS-cog and the DAD were 2.3, 11.4 and 15.1 points, respectively. Neither gender, duration of formal education, nor duration of AD since onset was significant predictors of cognitive and functional decline. Patterns of functional decline in total DAD, instrumental ADLs, planning and organization and performance subscale are linear as MMSE score declines, while those of the basic ADLs and the initiation are curvilinear.

CONCLUSION

This naturalistic observational study measured rates of cognitive and functional decline in AD, and can provide reference data for further longitudinal studies or clinical trials. Further study will be necessary to determine whether linear or curvilinear pattern in functional decline is due to progression of AD itself or statistical artifact.

Authors+Show Affiliations

Department of Psychiatry, Hallym University Medical Center, Hangang Sacred Heart Hospital, Seoul, Korea. suhgh@chollian.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15352138

Citation

Suh, Guk-Hee, et al. "A Longitudinal Study of Alzheimer's Disease: Rates of Cognitive and Functional Decline." International Journal of Geriatric Psychiatry, vol. 19, no. 9, 2004, pp. 817-24.
Suh GH, Ju YS, Yeon BK, et al. A longitudinal study of Alzheimer's disease: rates of cognitive and functional decline. Int J Geriatr Psychiatry. 2004;19(9):817-24.
Suh, G. H., Ju, Y. S., Yeon, B. K., & Shah, A. (2004). A longitudinal study of Alzheimer's disease: rates of cognitive and functional decline. International Journal of Geriatric Psychiatry, 19(9), 817-24.
Suh GH, et al. A Longitudinal Study of Alzheimer's Disease: Rates of Cognitive and Functional Decline. Int J Geriatr Psychiatry. 2004;19(9):817-24. PubMed PMID: 15352138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A longitudinal study of Alzheimer's disease: rates of cognitive and functional decline. AU - Suh,Guk-Hee, AU - Ju,Young-Su, AU - Yeon,Byeong Kil, AU - Shah,Ajit, PY - 2004/9/8/pubmed PY - 2004/10/16/medline PY - 2004/9/8/entrez SP - 817 EP - 24 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 19 IS - 9 N2 - OBJECTIVE: To measure rates of decline in cognition and function in patients with Alzheimer's disease (AD) and to investigate their accelerating risk factors in Korea. METHODS: This study presents longitudinal data on a community-based sample of 107 patients with AD, followed at 6 months and 12 months. The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), the Mini Mental State Examination (MMSE) and the Disability Assessment for Dementia Scale (DAD) were given. Mixed model analyses were conducted using the following independent variables: times of repeated assessment (0, 6 or 12 months), severity of dementia assessed by the Functional Assessment Staging (FAST) and individual indicators as covariates. RESULTS: Average annual rates of decline in the MMSE, the ADAS-cog and the DAD were 2.3, 11.4 and 15.1 points, respectively. Neither gender, duration of formal education, nor duration of AD since onset was significant predictors of cognitive and functional decline. Patterns of functional decline in total DAD, instrumental ADLs, planning and organization and performance subscale are linear as MMSE score declines, while those of the basic ADLs and the initiation are curvilinear. CONCLUSION: This naturalistic observational study measured rates of cognitive and functional decline in AD, and can provide reference data for further longitudinal studies or clinical trials. Further study will be necessary to determine whether linear or curvilinear pattern in functional decline is due to progression of AD itself or statistical artifact. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/15352138/A_longitudinal_study_of_Alzheimer's_disease:_rates_of_cognitive_and_functional_decline_ L2 - https://doi.org/10.1002/gps.1168 DB - PRIME DP - Unbound Medicine ER -