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[Supratentorial primitive neuroectodermal tumor: report of a surgical case].
No Shinkei Geka. 2004 Jun; 32(6):619-25.NS

Abstract

We reported a rare case of supratentorial primitive neuroectodermal tumors (sPNET) and reviewed the literature. A 15-year-old girl presented with a one-month history of headache and vomiting. CT scans showed a huge, solid and cystic tumor with calcification, occupying the left anterior cranial fossa. The solid portion of the tumor was hypointense on T1-weighted images, slightly hyperintense on T2-weighted images, hyperintense on diffusion- weighted images, isointense on fluid-attenuated inversion recovery (FLAIR) images, and strongly enhanced after administration of contrast medium. The expansile tumor had a broad attachment to the dura matter of the anterior cranial fossa. The patient underwent an uneventful extirpation of the tumor. Microscopically, the solid tumor contained small, round poorly-differentiated cells with pleomorphic nuclei and brisk mitotic activity. The tumor cells were immunoreactive for synaptophysin and GFAP, whereas lack of MIC2 gene product expression was confirmed using the monoclonal antibody 12E7. The MIB-1-positive rate was 43%. The histological diagnosis was sPNET. Postoperatively, a dose of 30.6Gy was administrated to the whole brain and a boost of 19.6Gy to the T2-hyperintensity lesion. The patient successively received a dose of 30.4Gy to the whole spine and Linac stereotactic radiotherapy with a marginal dose of 16.8Gy at the tumor bed. Three months after radiotherapy the patient received chemotherapy using carboplatin and etoposide. Follow-up MR images showed no evidence of recurrent tumor 5 months after the radiochemotherapy. On the basis of MR findings on both diffusion-weighted and FLAIR images, preoperative diagnosis of sPNET may be important for choosing appropriate therapeutic strategies for this tumor.

Authors+Show Affiliations

Department of Neurosurgery, Akita University School of Medicine, Akita-city, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

15352632

Citation

Omae, Tomoya, et al. "[Supratentorial Primitive Neuroectodermal Tumor: Report of a Surgical Case]." No Shinkei Geka. Neurological Surgery, vol. 32, no. 6, 2004, pp. 619-25.
Omae T, Takahashi M, Sasajima T, et al. [Supratentorial primitive neuroectodermal tumor: report of a surgical case]. No Shinkei Geka. 2004;32(6):619-25.
Omae, T., Takahashi, M., Sasajima, T., Sugawara, T., Kinouchi, H., Higashiyama, N., & Mizoi, K. (2004). [Supratentorial primitive neuroectodermal tumor: report of a surgical case]. No Shinkei Geka. Neurological Surgery, 32(6), 619-25.
Omae T, et al. [Supratentorial Primitive Neuroectodermal Tumor: Report of a Surgical Case]. No Shinkei Geka. 2004;32(6):619-25. PubMed PMID: 15352632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Supratentorial primitive neuroectodermal tumor: report of a surgical case]. AU - Omae,Tomoya, AU - Takahashi,Masataka, AU - Sasajima,Toshio, AU - Sugawara,Taku, AU - Kinouchi,Hiroyuki, AU - Higashiyama,Naoki, AU - Mizoi,Kazuo, PY - 2004/9/9/pubmed PY - 2004/9/21/medline PY - 2004/9/9/entrez SP - 619 EP - 25 JF - No shinkei geka. Neurological surgery JO - No Shinkei Geka VL - 32 IS - 6 N2 - We reported a rare case of supratentorial primitive neuroectodermal tumors (sPNET) and reviewed the literature. A 15-year-old girl presented with a one-month history of headache and vomiting. CT scans showed a huge, solid and cystic tumor with calcification, occupying the left anterior cranial fossa. The solid portion of the tumor was hypointense on T1-weighted images, slightly hyperintense on T2-weighted images, hyperintense on diffusion- weighted images, isointense on fluid-attenuated inversion recovery (FLAIR) images, and strongly enhanced after administration of contrast medium. The expansile tumor had a broad attachment to the dura matter of the anterior cranial fossa. The patient underwent an uneventful extirpation of the tumor. Microscopically, the solid tumor contained small, round poorly-differentiated cells with pleomorphic nuclei and brisk mitotic activity. The tumor cells were immunoreactive for synaptophysin and GFAP, whereas lack of MIC2 gene product expression was confirmed using the monoclonal antibody 12E7. The MIB-1-positive rate was 43%. The histological diagnosis was sPNET. Postoperatively, a dose of 30.6Gy was administrated to the whole brain and a boost of 19.6Gy to the T2-hyperintensity lesion. The patient successively received a dose of 30.4Gy to the whole spine and Linac stereotactic radiotherapy with a marginal dose of 16.8Gy at the tumor bed. Three months after radiotherapy the patient received chemotherapy using carboplatin and etoposide. Follow-up MR images showed no evidence of recurrent tumor 5 months after the radiochemotherapy. On the basis of MR findings on both diffusion-weighted and FLAIR images, preoperative diagnosis of sPNET may be important for choosing appropriate therapeutic strategies for this tumor. SN - 0301-2603 UR - https://www.unboundmedicine.com/medline/citation/15352632/[Supratentorial_primitive_neuroectodermal_tumor:_report_of_a_surgical_case]_ L2 - https://webview.isho.jp/openurl?rft.genre=article&rft.issn=0301-2603&rft.volume=32&rft.issue=6&rft.spage=619 DB - PRIME DP - Unbound Medicine ER -