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Does duration of untreated psychosis bias study samples of first-episode psychosis?
Acta Psychiatr Scand. 2004 Oct; 110(4):286-91.AP

Abstract

OBJECTIVE

While findings are contradictory, many studies report that long Duration of Untreated Psychosis (DUP) correlates with poorer outcome in first episode psychosis. In an outcome study of first-episode psychosis, we compared the patients who refused to participate in a follow-along with those who consented to estimate the importance of this factor in sample recruitment bias. Our questions were: (i) What is the percentage of refusers? (ii) Are there systematic differences between refusers and consenters on DUP and/or other admission variables? (iii) What is the risk of refusal for different values of DUP?

METHOD

In an unselected group of consecutively admitted patients we compared follow-along refusers and consenters on the following admission variables: sex, age, diagnostic group, substance abuse, being in-patient, coming from an early detection site and DUP. We conducted a logistic regression analysis with refusal as the outcome variable.

RESULTS

Ninety-three of 397 patients (23%) were refusers. In univariate analyses the only significant difference was found for DUP. The median DUP for consenters was 10 weeks and for refusers 32 weeks. DUP remained significant when all independent variables were controlled for.

CONCLUSION

DUP was significantly related to risk for refusal. For tests of the impact of DUP on outcome, this may introduce a type II error bias.

Authors+Show Affiliations

Department of Psychiatry, Ullevål University Hospital, Oslo, Norway. svien.friis@psykiatri.uio.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15352930

Citation

Friis, S, et al. "Does Duration of Untreated Psychosis Bias Study Samples of First-episode Psychosis?" Acta Psychiatrica Scandinavica, vol. 110, no. 4, 2004, pp. 286-91.
Friis S, Melle I, Larsen TK, et al. Does duration of untreated psychosis bias study samples of first-episode psychosis? Acta Psychiatr Scand. 2004;110(4):286-91.
Friis, S., Melle, I., Larsen, T. K., Haahr, U., Johannessen, J. O., Simonsen, E., Opjordsmoen, S., Vaglum, P., & McGlashan, T. H. (2004). Does duration of untreated psychosis bias study samples of first-episode psychosis? Acta Psychiatrica Scandinavica, 110(4), 286-91.
Friis S, et al. Does Duration of Untreated Psychosis Bias Study Samples of First-episode Psychosis. Acta Psychiatr Scand. 2004;110(4):286-91. PubMed PMID: 15352930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does duration of untreated psychosis bias study samples of first-episode psychosis? AU - Friis,S, AU - Melle,I, AU - Larsen,T K, AU - Haahr,U, AU - Johannessen,J O, AU - Simonsen,E, AU - Opjordsmoen,S, AU - Vaglum,P, AU - McGlashan,T H, PY - 2004/9/9/pubmed PY - 2005/1/12/medline PY - 2004/9/9/entrez SP - 286 EP - 91 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 110 IS - 4 N2 - OBJECTIVE: While findings are contradictory, many studies report that long Duration of Untreated Psychosis (DUP) correlates with poorer outcome in first episode psychosis. In an outcome study of first-episode psychosis, we compared the patients who refused to participate in a follow-along with those who consented to estimate the importance of this factor in sample recruitment bias. Our questions were: (i) What is the percentage of refusers? (ii) Are there systematic differences between refusers and consenters on DUP and/or other admission variables? (iii) What is the risk of refusal for different values of DUP? METHOD: In an unselected group of consecutively admitted patients we compared follow-along refusers and consenters on the following admission variables: sex, age, diagnostic group, substance abuse, being in-patient, coming from an early detection site and DUP. We conducted a logistic regression analysis with refusal as the outcome variable. RESULTS: Ninety-three of 397 patients (23%) were refusers. In univariate analyses the only significant difference was found for DUP. The median DUP for consenters was 10 weeks and for refusers 32 weeks. DUP remained significant when all independent variables were controlled for. CONCLUSION: DUP was significantly related to risk for refusal. For tests of the impact of DUP on outcome, this may introduce a type II error bias. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/15352930/Does_duration_of_untreated_psychosis_bias_study_samples_of_first_episode_psychosis L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0001-690X&date=2004&volume=110&issue=4&spage=286 DB - PRIME DP - Unbound Medicine ER -