Tags

Type your tag names separated by a space and hit enter

Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma.
Eur Respir J. 1992 May; 5(5):560-5.ER

Abstract

Although adenosine-induced bronchoconstriction is mainly due to mast cell mediator release, vagal reflexes have also been implicated in this response. We have investigated the effect of a specific muscarinic-receptor antagonist, ipratropium bromide, on methacholine- and adenosine-induced bronchoconstriction in a randomized, placebo-controlled, double-blind study of 12 asthmatic subjects. Airway response was evaluated as forced expiratory volume in one second (FEV1). Inhaled ipratropium bromide (40 micrograms), administered 20 min prior to bronchoprovocation, increased the provocation dose of inhaled methacholine and adenosine required to reduce FEV1 by 20% from baseline (PD20) from 0.11 to 0.79 mg (p less than 0.01) and from 0.57 to 1.27 mg (p less than 0.01), respectively. The mean baseline FEV1 values after administration of ipratropium bromide were significantly higher than after placebo administration (p less than 0.05). However, there was no correlation between the degree of bronchodilatation and dose-ratios for methacholine and adenosine. The findings of the present study implicate vagal reflexes in the bronchospastic response induced by inhaled adenosine in asthma.

Authors+Show Affiliations

Istituto di Malattie dell'Apparato Respiratorio e Tisiologia, Universita' di Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1535321

Citation

Crimi, N, et al. "Protective Effects of Inhaled Ipratropium Bromide On Bronchoconstriction Induced By Adenosine and Methacholine in Asthma." The European Respiratory Journal, vol. 5, no. 5, 1992, pp. 560-5.
Crimi N, Palermo F, Oliveri R, et al. Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma. Eur Respir J. 1992;5(5):560-5.
Crimi, N., Palermo, F., Oliveri, R., Polosa, R., Settinieri, I., & Mistretta, A. (1992). Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma. The European Respiratory Journal, 5(5), 560-5.
Crimi N, et al. Protective Effects of Inhaled Ipratropium Bromide On Bronchoconstriction Induced By Adenosine and Methacholine in Asthma. Eur Respir J. 1992;5(5):560-5. PubMed PMID: 1535321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma. AU - Crimi,N, AU - Palermo,F, AU - Oliveri,R, AU - Polosa,R, AU - Settinieri,I, AU - Mistretta,A, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 560 EP - 5 JF - The European respiratory journal JO - Eur Respir J VL - 5 IS - 5 N2 - Although adenosine-induced bronchoconstriction is mainly due to mast cell mediator release, vagal reflexes have also been implicated in this response. We have investigated the effect of a specific muscarinic-receptor antagonist, ipratropium bromide, on methacholine- and adenosine-induced bronchoconstriction in a randomized, placebo-controlled, double-blind study of 12 asthmatic subjects. Airway response was evaluated as forced expiratory volume in one second (FEV1). Inhaled ipratropium bromide (40 micrograms), administered 20 min prior to bronchoprovocation, increased the provocation dose of inhaled methacholine and adenosine required to reduce FEV1 by 20% from baseline (PD20) from 0.11 to 0.79 mg (p less than 0.01) and from 0.57 to 1.27 mg (p less than 0.01), respectively. The mean baseline FEV1 values after administration of ipratropium bromide were significantly higher than after placebo administration (p less than 0.05). However, there was no correlation between the degree of bronchodilatation and dose-ratios for methacholine and adenosine. The findings of the present study implicate vagal reflexes in the bronchospastic response induced by inhaled adenosine in asthma. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1535321/Protective_effects_of_inhaled_ipratropium_bromide_on_bronchoconstriction_induced_by_adenosine_and_methacholine_in_asthma_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -