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Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin.
Clin Endocrinol (Oxf). 2004 Sep; 61(3):339-46.CE

Abstract

OBJECTIVE

Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA).

DESIGN

Cross-sectional, hospital-based study dealing with insulin sensitivity in SGA children.

PATIENTS

Thirty-two prepubertal children born SGA (age 5.4 +/- 2.9 years) and 37 prepubertal children born appropriate for gestational age (AGA, age 5.9 +/- 3.0 years).

MEASUREMENTS

Serum levels of fasting glucose, serum lipids, insulin (immunometric assay) and adiponectin concentrations (ELISA) were assessed, and insulin resistance (IR) and insulin secretion (beta-cell) were calculated by the homeostasis model of assessment (HOMA).

RESULTS

SGA children had similar HOMA-IR, HOMA-beta-cell and adiponectin concentrations than AGA children. However, in a separate analysis of subjects older than 3 years of age, SGA children showed higher HOMA-IR after adjusting for sex, age and body mass index (BMI) standard deviation score (SDS). Circulating adiponectin was higher in SGA children [adjusted means: 14.5 mg/l (95% CI 12.9-16.1) and 18.7 mg/l (95% CI 17.0-20.3) for AGA and SGA children, respectively; P < 0.0001]. Further analysis revealed that the group of overweight SGA (arbitrarily defined as being in the higher quartile for the BMI SDS distribution in the sample) had decreased serum concentrations of adiponectin, compared to lean SGA children [adjusted means: 12.9 mg/l (95% CI 9.3-16.5) vs. 19.0 (95% CI 16.8-21.3), respectively; P = 0.001]. In a multiple regression model, HOMA-IR and SGA status explained 35% and 15% of adiponectin variance, respectively.

CONCLUSIONS

Prenatal growth restriction is associated with insulin resistance but relatively increased adiponectin concentrations, provided overweight does not ensue. The contributions of circulating adiponectin to the increased risks for developing insulin resistance and type-2 diabetes in formerly SGA subjects merit further studies.

Authors+Show Affiliations

Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital of Girona, Girona, Spain. uden.alopez@htrueta.scs.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15355450

Citation

López-Bermejo, Abel, et al. "Both Intrauterine Growth Restriction and Postnatal Growth Influence Childhood Serum Concentrations of Adiponectin." Clinical Endocrinology, vol. 61, no. 3, 2004, pp. 339-46.
López-Bermejo A, Casano-Sancho P, Fernández-Real JM, et al. Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin. Clin Endocrinol (Oxf). 2004;61(3):339-46.
López-Bermejo, A., Casano-Sancho, P., Fernández-Real, J. M., Kihara, S., Funahashi, T., Rodríguez-Hierro, F., Ricart, W., & Ibañez, L. (2004). Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin. Clinical Endocrinology, 61(3), 339-46.
López-Bermejo A, et al. Both Intrauterine Growth Restriction and Postnatal Growth Influence Childhood Serum Concentrations of Adiponectin. Clin Endocrinol (Oxf). 2004;61(3):339-46. PubMed PMID: 15355450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Both intrauterine growth restriction and postnatal growth influence childhood serum concentrations of adiponectin. AU - López-Bermejo,Abel, AU - Casano-Sancho,Paula, AU - Fernández-Real,José Manuel, AU - Kihara,Shinji, AU - Funahashi,Tohru, AU - Rodríguez-Hierro,Francisco, AU - Ricart,Wifredo, AU - Ibañez,Lourdes, PY - 2004/9/10/pubmed PY - 2005/3/16/medline PY - 2004/9/10/entrez SP - 339 EP - 46 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 61 IS - 3 N2 - OBJECTIVE: Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN: Cross-sectional, hospital-based study dealing with insulin sensitivity in SGA children. PATIENTS: Thirty-two prepubertal children born SGA (age 5.4 +/- 2.9 years) and 37 prepubertal children born appropriate for gestational age (AGA, age 5.9 +/- 3.0 years). MEASUREMENTS: Serum levels of fasting glucose, serum lipids, insulin (immunometric assay) and adiponectin concentrations (ELISA) were assessed, and insulin resistance (IR) and insulin secretion (beta-cell) were calculated by the homeostasis model of assessment (HOMA). RESULTS: SGA children had similar HOMA-IR, HOMA-beta-cell and adiponectin concentrations than AGA children. However, in a separate analysis of subjects older than 3 years of age, SGA children showed higher HOMA-IR after adjusting for sex, age and body mass index (BMI) standard deviation score (SDS). Circulating adiponectin was higher in SGA children [adjusted means: 14.5 mg/l (95% CI 12.9-16.1) and 18.7 mg/l (95% CI 17.0-20.3) for AGA and SGA children, respectively; P < 0.0001]. Further analysis revealed that the group of overweight SGA (arbitrarily defined as being in the higher quartile for the BMI SDS distribution in the sample) had decreased serum concentrations of adiponectin, compared to lean SGA children [adjusted means: 12.9 mg/l (95% CI 9.3-16.5) vs. 19.0 (95% CI 16.8-21.3), respectively; P = 0.001]. In a multiple regression model, HOMA-IR and SGA status explained 35% and 15% of adiponectin variance, respectively. CONCLUSIONS: Prenatal growth restriction is associated with insulin resistance but relatively increased adiponectin concentrations, provided overweight does not ensue. The contributions of circulating adiponectin to the increased risks for developing insulin resistance and type-2 diabetes in formerly SGA subjects merit further studies. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15355450/Both_intrauterine_growth_restriction_and_postnatal_growth_influence_childhood_serum_concentrations_of_adiponectin_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0300-0664&amp;date=2004&amp;volume=61&amp;issue=3&amp;spage=339 DB - PRIME DP - Unbound Medicine ER -