Tags

Type your tag names separated by a space and hit enter

Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case-control study in Southern England.
J Oral Pathol Med. 2004 Oct; 33(9):525-32.JO

Abstract

BACKGROUND

This case-control study aimed to identify the risk factors for oral cancer in patients aged 45 years and under.

METHODS

Patients were recruited over a 3-year period between 1999 and 2001 from 14 hospitals in the southeast of England, UK.

RESULTS

Fifty-three (80%) newly diagnosed patients with squamous cell carcinoma (SCC) of the oral cavity participated. The mean age of cases at diagnosis was 38.5 years (SD = 7.0) and 53% were male. Patients were interviewed about main risk factors of tobacco, alcohol, cannabis and their consumption of fresh fruit and vegetables in the past. Ninety-one matched control patients were also recruited. Odds ratios (ORs) and 95% confidence intervals (CI) were obtained from adjusted conditional logistic analyses. Significantly elevated ORs were evidenced amongst males who had started to smoke under the age of 16 years (OR = 14.3; 95% CI: 1.1-178.8). A significant reduction in risk was also shown for ex-smokers (OR = 0.2; 95% CI: 0.5-0.8). Consumption of alcohol in excess of recommended amounts also produced an eightfold risk in males (OR = 8.1; 95% CI: 1.6-40.1) and over a fourfold risk of oral cancer from the consumption of excessive amounts of alcohol and having ever smoked (OR = 4.4; 95% CI: 1.1-17.7).

CONCLUSION

The study shows that the traditional behavioural risk factors are present in younger people diagnosed with oral cancer. The relatively short duration of exposure and the substantial number of cases without any known risk factors, particularly amongst females, however, suggest that factors other than tobacco and alcohol may also be implicated in the development of oral cancer in a proportion of these younger patients.

Authors+Show Affiliations

Department of Oral Medicine and Pathology, Guy's, King's and St Thomas' Dental Institute, WHO Collaborating Centre for Oral Cancer and Precancer, King's College London, Denmark Hill Campus, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15357672

Citation

Llewellyn, C D., et al. "Risk Factors for Oral Cancer in Newly Diagnosed Patients Aged 45 Years and Younger: a Case-control Study in Southern England." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 33, no. 9, 2004, pp. 525-32.
Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case-control study in Southern England. J Oral Pathol Med. 2004;33(9):525-32.
Llewellyn, C. D., Johnson, N. W., & Warnakulasuriya, K. A. (2004). Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case-control study in Southern England. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 33(9), 525-32.
Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk Factors for Oral Cancer in Newly Diagnosed Patients Aged 45 Years and Younger: a Case-control Study in Southern England. J Oral Pathol Med. 2004;33(9):525-32. PubMed PMID: 15357672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case-control study in Southern England. AU - Llewellyn,C D, AU - Johnson,N W, AU - Warnakulasuriya,K A A S, PY - 2004/9/11/pubmed PY - 2004/11/17/medline PY - 2004/9/11/entrez SP - 525 EP - 32 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J. Oral Pathol. Med. VL - 33 IS - 9 N2 - BACKGROUND: This case-control study aimed to identify the risk factors for oral cancer in patients aged 45 years and under. METHODS: Patients were recruited over a 3-year period between 1999 and 2001 from 14 hospitals in the southeast of England, UK. RESULTS: Fifty-three (80%) newly diagnosed patients with squamous cell carcinoma (SCC) of the oral cavity participated. The mean age of cases at diagnosis was 38.5 years (SD = 7.0) and 53% were male. Patients were interviewed about main risk factors of tobacco, alcohol, cannabis and their consumption of fresh fruit and vegetables in the past. Ninety-one matched control patients were also recruited. Odds ratios (ORs) and 95% confidence intervals (CI) were obtained from adjusted conditional logistic analyses. Significantly elevated ORs were evidenced amongst males who had started to smoke under the age of 16 years (OR = 14.3; 95% CI: 1.1-178.8). A significant reduction in risk was also shown for ex-smokers (OR = 0.2; 95% CI: 0.5-0.8). Consumption of alcohol in excess of recommended amounts also produced an eightfold risk in males (OR = 8.1; 95% CI: 1.6-40.1) and over a fourfold risk of oral cancer from the consumption of excessive amounts of alcohol and having ever smoked (OR = 4.4; 95% CI: 1.1-17.7). CONCLUSION: The study shows that the traditional behavioural risk factors are present in younger people diagnosed with oral cancer. The relatively short duration of exposure and the substantial number of cases without any known risk factors, particularly amongst females, however, suggest that factors other than tobacco and alcohol may also be implicated in the development of oral cancer in a proportion of these younger patients. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/15357672/Risk_factors_for_oral_cancer_in_newly_diagnosed_patients_aged_45_years_and_younger:_a_case_control_study_in_Southern_England_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0904-2512&date=2004&volume=33&issue=9&spage=525 DB - PRIME DP - Unbound Medicine ER -