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A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries.
J Am Coll Cardiol 2004; 44(3):579-85JACC

Abstract

OBJECTIVES

The object of this study was to assess the effects of menopause and a diet/exercise intervention on subclinical atherosclerosis progression.

BACKGROUND

Subclinical atherosclerosis has been linked to higher coronary heart disease and stroke rates and is greater among postmenopausal women according to cross-sectional analyses. Whether menopause is associated with an accelerated progression of subclinical disease is unknown, as is the extent to which lifestyle intervention can alter the course of progression.

METHODS

Intima-media thickness (IMT) measures of the common carotid artery (CCA), internal carotid artery (ICA), and bulb segments of the carotid arteries were measured twice during the course of 4 years in 353 women from the Women's Healthy Lifestyle Project, a dietary and exercise clinical trial designed to prevent adverse risk factor changes through the menopause. A third measure was obtained 2.5 years later for 113 women.

RESULTS

The progression of IMT was observed for the average of all segments (AVG), the CCA, and the bulb (0.007 mm/year, 0.008 mm/year, and 0.012 mm/year; p < 0.01 for all), but not for the ICA. Among controls, menopause was associated with accelerated IMT progression (0.003 mm/year for premenopausal women vs. 0.008 mm/year for perimenopausal/postmenopausal women for AVG IMT; p = 0.049). Additionally, among the 160 perimenopausal/postmenopausal women, the intervention slowed IMT progression (0.008 mm/year for the control group vs. 0.004 mm/year for the intervention group for AVG IMT; p = 0.02). Similar results were found for the CCA and bulb segments.

CONCLUSIONS

These data demonstrate that the menopause transition is associated with accelerated subclinical atherosclerosis progression and that a diet/exercise intervention slows menopause-related atherosclerosis progression.

Authors+Show Affiliations

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15358024

Citation

Wildman, Rachel P., et al. "A Dietary and Exercise Intervention Slows Menopause-associated Progression of Subclinical Atherosclerosis as Measured By Intima-media Thickness of the Carotid Arteries." Journal of the American College of Cardiology, vol. 44, no. 3, 2004, pp. 579-85.
Wildman RP, Schott LL, Brockwell S, et al. A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries. J Am Coll Cardiol. 2004;44(3):579-85.
Wildman, R. P., Schott, L. L., Brockwell, S., Kuller, L. H., & Sutton-Tyrrell, K. (2004). A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries. Journal of the American College of Cardiology, 44(3), pp. 579-85.
Wildman RP, et al. A Dietary and Exercise Intervention Slows Menopause-associated Progression of Subclinical Atherosclerosis as Measured By Intima-media Thickness of the Carotid Arteries. J Am Coll Cardiol. 2004 Aug 4;44(3):579-85. PubMed PMID: 15358024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries. AU - Wildman,Rachel P, AU - Schott,Laura L, AU - Brockwell,Sarah, AU - Kuller,Lewis H, AU - Sutton-Tyrrell,Kim, PY - 2003/11/25/received PY - 2004/03/08/revised PY - 2004/03/16/accepted PY - 2004/9/11/pubmed PY - 2004/9/24/medline PY - 2004/9/11/entrez SP - 579 EP - 85 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 44 IS - 3 N2 - OBJECTIVES: The object of this study was to assess the effects of menopause and a diet/exercise intervention on subclinical atherosclerosis progression. BACKGROUND: Subclinical atherosclerosis has been linked to higher coronary heart disease and stroke rates and is greater among postmenopausal women according to cross-sectional analyses. Whether menopause is associated with an accelerated progression of subclinical disease is unknown, as is the extent to which lifestyle intervention can alter the course of progression. METHODS: Intima-media thickness (IMT) measures of the common carotid artery (CCA), internal carotid artery (ICA), and bulb segments of the carotid arteries were measured twice during the course of 4 years in 353 women from the Women's Healthy Lifestyle Project, a dietary and exercise clinical trial designed to prevent adverse risk factor changes through the menopause. A third measure was obtained 2.5 years later for 113 women. RESULTS: The progression of IMT was observed for the average of all segments (AVG), the CCA, and the bulb (0.007 mm/year, 0.008 mm/year, and 0.012 mm/year; p < 0.01 for all), but not for the ICA. Among controls, menopause was associated with accelerated IMT progression (0.003 mm/year for premenopausal women vs. 0.008 mm/year for perimenopausal/postmenopausal women for AVG IMT; p = 0.049). Additionally, among the 160 perimenopausal/postmenopausal women, the intervention slowed IMT progression (0.008 mm/year for the control group vs. 0.004 mm/year for the intervention group for AVG IMT; p = 0.02). Similar results were found for the CCA and bulb segments. CONCLUSIONS: These data demonstrate that the menopause transition is associated with accelerated subclinical atherosclerosis progression and that a diet/exercise intervention slows menopause-related atherosclerosis progression. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15358024/A_dietary_and_exercise_intervention_slows_menopause_associated_progression_of_subclinical_atherosclerosis_as_measured_by_intima_media_thickness_of_the_carotid_arteries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(04)00993-3 DB - PRIME DP - Unbound Medicine ER -