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Olanzapine increases plasma ghrelin level in patients with schizophrenia.
Psychoneuroendocrinology 2005; 30(1):106-10P

Abstract

OBJECTIVE

Increased appetite and weight gain are frequently reported in treatment with olanzapine. However, the mechanism behind this appetite gain remains unclear. Ghrelin is a newly discovered appetite-stimulating peptide that has a role in the regulation of feeding behavior. Ghrelin is synthesized principally in the stomach, and the concentration of circulating ghrelin is negatively correlated with leptin and body fat mass. To elucidate the mechanism of appetite and weight gain during olanzapine treatment, we investigated the circulating ghrelin levels.

METHODS

Seven patients with schizophrenia were examined before and after 6-month administration of olanzapine. The concentrations of circulating ghrelin, leptin, glucose and lipid metabolic parameters were measured.

RESULTS

Body fat percentage (P=0.0121) and serum leptin (P=0.0284) were significantly increased after 6-month administration of olanzapine. Both plasma total ghrelin (P=0.0188) and active ghrelin levels (P=0.0057) were significantly increased. Six of the seven patients reported increased appetite during olanzapine treatment. Other glucose and lipid parameters were not altered significantly.

CONCLUSIONS

Although, the leptin level and body fat percentage were significantly increased, the concentration of circulating ghrelin was also significantly increased. Olanzapine may directly act on the secretion of ghrelin and induce appetite, resulting in weight gain.

Authors+Show Affiliations

Department of Psychiatry, Hokkaido University Graduate School of Medicine, North-14, West-7, Sapporo 060-8638, Japan. tm-mura@jb3.so-net.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15358448

Citation

Murashita, Mari, et al. "Olanzapine Increases Plasma Ghrelin Level in Patients With Schizophrenia." Psychoneuroendocrinology, vol. 30, no. 1, 2005, pp. 106-10.
Murashita M, Kusumi I, Inoue T, et al. Olanzapine increases plasma ghrelin level in patients with schizophrenia. Psychoneuroendocrinology. 2005;30(1):106-10.
Murashita, M., Kusumi, I., Inoue, T., Takahashi, Y., Hosoda, H., Kangawa, K., & Koyama, T. (2005). Olanzapine increases plasma ghrelin level in patients with schizophrenia. Psychoneuroendocrinology, 30(1), pp. 106-10.
Murashita M, et al. Olanzapine Increases Plasma Ghrelin Level in Patients With Schizophrenia. Psychoneuroendocrinology. 2005;30(1):106-10. PubMed PMID: 15358448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olanzapine increases plasma ghrelin level in patients with schizophrenia. AU - Murashita,Mari, AU - Kusumi,Ichiro, AU - Inoue,Takeshi, AU - Takahashi,Yoshito, AU - Hosoda,Hiroshi, AU - Kangawa,Kenji, AU - Koyama,Tsukasa, PY - 2004/02/02/received PY - 2004/05/20/revised PY - 2004/05/20/accepted PY - 2004/9/11/pubmed PY - 2004/12/16/medline PY - 2004/9/11/entrez SP - 106 EP - 10 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 30 IS - 1 N2 - OBJECTIVE: Increased appetite and weight gain are frequently reported in treatment with olanzapine. However, the mechanism behind this appetite gain remains unclear. Ghrelin is a newly discovered appetite-stimulating peptide that has a role in the regulation of feeding behavior. Ghrelin is synthesized principally in the stomach, and the concentration of circulating ghrelin is negatively correlated with leptin and body fat mass. To elucidate the mechanism of appetite and weight gain during olanzapine treatment, we investigated the circulating ghrelin levels. METHODS: Seven patients with schizophrenia were examined before and after 6-month administration of olanzapine. The concentrations of circulating ghrelin, leptin, glucose and lipid metabolic parameters were measured. RESULTS: Body fat percentage (P=0.0121) and serum leptin (P=0.0284) were significantly increased after 6-month administration of olanzapine. Both plasma total ghrelin (P=0.0188) and active ghrelin levels (P=0.0057) were significantly increased. Six of the seven patients reported increased appetite during olanzapine treatment. Other glucose and lipid parameters were not altered significantly. CONCLUSIONS: Although, the leptin level and body fat percentage were significantly increased, the concentration of circulating ghrelin was also significantly increased. Olanzapine may directly act on the secretion of ghrelin and induce appetite, resulting in weight gain. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/15358448/Olanzapine_increases_plasma_ghrelin_level_in_patients_with_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(04)00074-5 DB - PRIME DP - Unbound Medicine ER -